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K Donath

Publications and source records attributed to K Donath.

At least 145 records · Page 8Linked to original sources
PubMed1984

The embryonal carcinoma of the parotid gland. A rare example of an embryonal tumor.

Embryonal tumors are a neoplastic proliferation of cells of organ rudiments. Morphologically, these tumors are similar to the developmental stages of these organ rudiments. Embryonal tumors of the salivary glands have not been previously described. In the salivary gland register, reviewing the years 1965-1982 (n = 8043), we diagnosed 2,878 tumors of the salivary glands, of these 73 were tumors in children. One case was a malignant epithelial tumor in a 12-year-old boy, which showed the criteria of an embryonal carcinoma in light- and electron microscopy. The tumor revealed solid undifferentiated areas, epidermoid structures with keratinization and acinic structures. Immunhistochemically, the better differentiated epidermoid cells reacted positively with anti-CEA and anti-keratin, the acinic cells were positive with anti-amylase. The ultrastructure was characterized by primitive ductular epithelial cells and acinic cells with their typical morphological features. The embryonal carcinoma has to be distinguished from undifferentiated carcinomas of the salivary glands, which consist of primitive ductular structures only. The failure to detect other tumor markers (lactoferrin, tissue polypeptid antigen) indicates that poorly and well differentiated areas can exist simultaneously in embryonal carcinomas.

Child↗
PubMed1982

A method for the study of undecalcified bones and teeth with attached soft tissues. The Säge-Schliff (sawing and grinding) technique.

A new sawing-grinding method is described for the histological evaluation of jaw bones with teeth or bones containing implants (ceramic or metallic). The undecalcified bone is embedded in acrylic resin and sawed at 100 to 150 micrometers. The slices are ground automatically by a special machine to a thickness of 5-10 micrometers. The usually employed staining procedures for hard plastic embedded-tissues may be used. Plaque, fillings, crowns, bridges, implants and soft tissues are preserved in situ. Macroscopic and microscopic detail of good quality is preserved for histological and morphometrical evaluation.

Adult↗
PubMed1982

[Diffuse oncocytosis of the parotid gland. Definition and differential diagnosis].

Diffuse oncocytosis represents an extremely rare, nontumourous alteration of the parotid gland which could be observed in only 2 cases in a group of over 7000 salivary gland cases. Viewed under the light microscope, the glandular lobuli show complete oncocytic metaplasia of the acinar cells and the duct epithelia. The oncocytic cells are characterized by a swollen granular acidophilic cytoplasm. In semi-thin sections, transformed oncocytic clear basal cells are found in the vicinity of typical oncocytes. The electron microscope shows that the oncocytes contain multiple mitochondria in the cytoplasm. The mitochondria are almost always swollen, display cristolysis very often and contain osmiophilic granules. The ductular oncocytes are characterized by isolated tonofilaments, whereas the myoepithelial oncocytes are notable for peripherally arranged myofilaments. The endothelial cells of the vessels show hydropic swelling. Ultrastructural changes are observed in the terminal axons of the vegetative nervous system of the parotid gland. Diffuse oncocytosis is an intracellular metabolic disturbance associated with mitochondriopathy. Its occurrence in elderly persons is suggestive of an age-dependent metabolic defect. In differential diagnosis, diffuse oncocytosis must be differentiated from sialadenosis which is a primarily vegetative neuropathy with secretory disturbance of the acinic cells, and from oncocytic neoplasias, especially from oncocytomas and cystadenolymphomas. Oncocytic adenomatous hyperplasia is a different disease. It represents a multifocal oncocytic proliferation of the duct system. Typical oncocytomas may perhaps develop from such oncocytic proliferation by a tendency to confluent growth.

Adenoma↗
PubMed1981

[Changes of the lip salivary glands in glossodynia. Histologic and morphometric analysis (author's transl)].

The minor salivary glands of the lower lips were analyzed histologically and morphometrically from biopsy specimens taken from 29 patients with glossodynia and 12 normal controls. The causes of glossodynia included Sjögrens syndrome [5], stomatological disorders such as diabetes mellitus, prosthesis allergy, etc. [5], psychiatric depressions [6], and idiopathic [13]. Using semi-thin tissue sections, the following results were obtained: 1. The control group had an average acinous area of 70.2%. This area was moderately reduced in the older patient. In patients with glossdynia, the acinous area was reduced to a mean value of 38.9%. Some severe cases showed values of 10% and less. 2. The area of duct structures was 9.3% in control tissues, and increased to 13.1% in patients with glossodynia. Values to 26% were rarely observed. 3. The interstitial tissue of the control group was inconspicuous and contained only few inflammatory cells. In glossodynia, the reduction of glandular acini could be positively correlated with the proliferation of the connective tissue and to stromal infiltration by lymphocytes and plasma cells. In diffuse lymphocytic sialadenitis, the mean value of the acinous area was 46%. An additional focal lymphocytic infiltration resulted in a further reduction to 27.3%. 4. The most severe cases of sialadenitis were found in glossodynia associated with Sjögren's syndrome. As such, the lip biopsy was found to be a useful method for diagnosis of the syndrome.

Adult↗
PubMed1981

[Mucoceles of the minor salivary glands. Extravasation mucoceles (mucus granulomas) and retention mucoceles (mucus retention cysts) (author's transl)].

360 cases of salivary glands cysts (= 6%) were collected in the Salivary Glands Register (Institute of Pathology, University of Hamburg) from 1965 until 1979 among a total of 5739 register cases. 273 cases of the cystic lesions (= 76%) were mucoceles of the minor salivary glands. The analysis of these 273 cases revealed the following results: 1. Two types of mucoceles can be morphologically distinguished: extravasation mucoceles and retention mucoceles. 2. The extravasation mucocele is in our material (240 cases = 88.7%) the most frequent type of mucocele. The term "extravasation mucocele" of the anglo-american literature is identical with the term "mucus granuloma" ("Schleimgranulom") introduced by Hamperl (1932). 3. The main signs of the mucus granulomas are: predominant location (79%) at the lower lip, age peak in the 2nd decade and more frequent occurrence (in 60%) in the male sex. 4. Three stages of development can be distinguished in the pathogenesis of the mucus granulomas: an initial stage (interstitial mucus lakes), a resorption stage (mucus granulomas with macrophages, foam cells and foreign bodies giant cells) and a terminal stage with the development of a pseudocyst (capsule of collagen tissue, no epithelial demarcation). 5. The retention mucocele (synonym: mucus retention cyst) is a rare type of mucocele (33 cases = 11.3%). The main signs are: nearly equal occurrence in all oral regions, age peak in the 8th decade, moderate predominance of the female sex. 6. The retention mucoceles contain viscous mucous material, possess always an epithelial demarcation of the cysts differentiated analogous to the different segments of the salivary duct system and show as a rule no inflammatory reaction compared with the extravasation mucoceles. 7. Microtraumas and mucus congestions play the important role in the development of the extravasation mucocele. The final formation depends on the amount of the overflowed mucus and the intensity of the mucus phagocytosis. 8. Partial obstructions of the ducts are considered as the important factor in the development of the retention mucocele. Besides, relations are discussed to high differentiated monomorphic adenomas. 9. In differential diagnosis, the retention mucoceles must be distinguished from other salivary glands cysts (lymphoepithelial cysts etc.), the extravasation mucoceles from other granulomatous reactions of the salivary glands.

Adolescent↗