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Biomedical subjects

K Dietzmann

Publications and source records attributed to K Dietzmann.

At least 91 records · Page 5Linked to original sources
PubMed1981

[Melanosis cerebri of human: a contribution of the pigment composition. 1. Light microscopic and histochemical investigations (author's transl)].

The procedure of a topochemical and histological investigation of a rare pigmentation in the cerebellum, especially of the nucleus dentatus cerebelli is described. The actual results of the pigment analysis suggest that the pigment may belong to the group of melanin. It occurs as extraneuronal polygonal structure. The prepigments are rich of chromolipoids and will transmit in a melanin with a nonenzymatic oxidation.

Cerebellar Diseases↗
PubMed1981

[Histochemical demonstration of enzyme activity changes in the regio postcentralis of the mouse brain under the effect of the aging process].

The distribution of some oxidoreductases were investigated in the regio postcentralis of young, adult and senescent mice brains by means of semiquantitative histoenzymatic methods. It was possible to observe a different spread of activities of 1-malate: NAD oxidoreductase (EC 1.1.1.37) and D-glucose-6-phosphate: NADP oxidoreductase (EC 1.1.1.49) in several layers of the regio postcentralis between young and old animals. The enzyme products of 1-glutamate:NAD(P) oxidoreductase (EC 1.4.1.3), 1-alpha-glycerine-3-phosphate:NAD oxidoreductase (EC 1.1.1.8) and D-glucose-6-phosphate:NADP oxidoreductase (EC 1.1.1.49) in the whole area show a decrease after the 20th month of the life, but it exists strain differences. The investigated enzymes of citric acid cycle were not vary in the ageing process.

Aging↗
PubMed1980

A contribution to the postnatal enzymatic state of maturity of gyrus hippocampi in the embryofetal alcohol syndrome of the rat.

The influence of maternal chronic alcoholism on fetal brain development was investigated in rats. A decrease in the activity of succinate, glycerin-1-phosphate, glucose-6-phosphate dehydrogenases and of tetrazolium reductases was found. The amount of total RNA was reduced in the neonates with alcohol damage. Moreover, a retardation of myelinisation at the time of birth was observed.

Animals↗
PubMed1979

[Enzymatic chemoarchitecture of the isocortex of humans (area 10 of Brodmann)].

The distributions of some oxidoreductases, esterases and phosphatases were investigated in the area 10 (lobus frontalis cerebri) of old human brains by means of histoenzymatic methods. It was possible to observe a different spread of enzymatic activites of hydrolases and oxidoreductases in the several layers of human frontal cortex. The microphotometrical gradation of oxidoreductases was identical with the results of the most mammal brains with the exception of the alpha-glycerophosphate dehydrogenase. The enzyme products of this oxidoreductase show a increase in the lamina 6 and in the subcortex. The cause of the culmination is not jet clear.

Acid Phosphatase↗
PubMed1978

[Histochemistry of the ball cell in larval epidermis of Xenopus laevis Daudin].

Presented investigations of chemical composition and metabolism of ball cell in larval epidermis of Xenopus point to a regressive shape of cell corresponding to former light and electron microscopical findings. The lower requirements of energy of this cell are covered by glycolysis and possibly by pentose phosphate cycle. Our hypothesis of pressure-elastic ball of cell as structural element of larval epidermis could been further supported.

Amino Acids↗
PubMed1977

Histological and histochemical studies on the rat brain under conditions of carbon disulfide intoxication.

The brains of 35 male Wistar rats weighing 250 g were histologically and histochemically examined after a chronic intoxication due to five-month exposure to carbon disulfide. Morphologically, myelin sheath disruptions within the longitudinal tract systems of the spinal cord, destructions of individual ganglion cells in all brain regions and elective parenchyma necroses in the frontal and parietal cerebral cortices were found. The histochemical assays for enzyme activities of monoamine oxidase, ATPase, glucose 6-phosphatase, acetylcholine esterase and succinic dehydrogenase in the entire central nervous system revealed values identical to those obtained for control animals. Only succinic dehydrogenase and acetylcholine esterase revealed focal reduction in activities within the elective parenchyma necroses. After twenty-week duration of experiments a moderate decrease in activities of arylsulfatases and glutamic dehydrogenase in the entire central nervous system was found. Eventual causes responsible for these changes are discussed.

Animals↗
PubMed1976

An experimental model for inducing fetal hypotrophy in the rabbit.

Intravenous injection of a saponin-collargol solution into pregnant rabbits induced, in addition to haemolysis and decrease in body weight of the gravid animals, a dose-dependent intrauterine deficient development of the fetuses accompanied by pronounced general reduction in body weight and disproportionate growth of fetal organs. Brain, heart, lungs, and the kidneys to a lesser degree, were found to be comparatively heavier when compared to the total body weight. The reasons discussed are hypoxia-dependent deficiency in glycogen and glucose, nutritional factors resulting from malnutrition, intoxication, and placental insufficiency due to infarctions, particularly for groups II and III.

Animals↗
PubMed1975

Determination of the glycogen contents in the brains of perinatal and newborn rabbits under conditions of experimental hypoxia.

The glycogen contents of 121 rabbit brains having different levels of hypoxia were determined, calculation being in mg% of glucose per g of brain. It was possible to observe significant reductions in carbohydrate content under conditions of acute and chronic hypoxia. Moderate prepartum accumulation of glycogen in untreated rabbit brains is likely. Chronic reduction in reserve fuel resulted in deficient development of the brain, as is clearly shown by brain weight determinations. This enables a parallel between this condition and intrauterine dystrophia.

Animals↗