Search PubMed⌕ Search

Biomedical subjects

K Dhall

Publications and source records attributed to K Dhall.

At least 37 records · Page 2Linked to original sources
PubMed1989

Survey of cutaneous lesions in Indian newborns.

A total of 900 consecutive newborns delivered at the Nehru Hospital, Chandigarh, India, over a period of 7 months were examined for presence of skin lesions within 48 hours of birth. Commonly observed skin lesions were Epstein pearls (88.7%), mongolian spots (62.2%), milia (34.9%), sebaceous hyperplasia (31.8%), salmon patches (28.4%), and erythema toxicum neonatorum (20.6%). These figures are comparable with earlier reports. Impetigo neonatorum occurred in 11.3% of infants, and was frequent in our hot and humid climate from May to August. Traumatic skin lesions were most often present in babies who had forceps deliveries. Three hundred ten (34%) babies were available for follow-up up to six weeks. Additional skin lesions observed were omphalitis (16 babies), oral thrush (9) and postinflammatory hypomelanosis (8). Three infants had atopic dermatitis, two each had seborrheic dermatitis, diaper dermatitis, pityriasis versicolor, and nevus achromicus. One each had vitiligo, ichthyosis vulgaris, urticaria, and strawberry hemangioma. These observations highlight the importance of repeat examination for the appearance of skin lesions during the neonatal period.

Female↗
PubMed1988

Isolation and chemical composition of surface-active material from human lung lavage.

Surface-active material (SF) was isolated from human lung lavage fluid collected at autopsy employing differential and sucrose density gradient centrifugation. The isolated material showed well-defined electron microscopic structure, consisting of clearly preserved, closely packed vesicles with limiting membranes and inclusion bodies. It showed a very high degree of alkaline phosphatase specific activity and was devoid of other subcellular contaminants. The isolated material also showed a high phospholipid/protein ratio and increasing surface activity when monitored at different stages of purification. It contained 68.5% phosphatidylcholine, 11.5% phosphatidylglycerol and relatively smaller amounts of phosphatidylethanolamine and other individual phospholipid (PL) classes. In addition, cholesterol, unesterified fatty acids, triacylglycerols and other neutral lipids were found. Saturated fatty acids, particularly palmitic acid (16:0), predominated in the major PL fractions. However, various fatty acids of which oleic acid (18:1) constituted a large proportion also are present. Chemical analysis of the material showed that besides lipids and proteins, nucleic acids, sialic acid, hexose, amino sugars, nitrogen and phosphorus were present. The delipidated material showed the presence of three to four proteins as characterized by sodium dodecylsulfate (SDS)-polyacrylamide gel electrophoresis, and gel permeation chromatography on Sephadex G-200 resolved two well-separated peaks. The first fraction contained serum-associated 68 kDa protein, while the second fraction had two apoproteins with molecular weights of 34 kDa and 10 kDa. These two proteins were associated with the SF and they, as well as the whole surface-active material, strongly reacted with the antibody directed against the whole SF in a double-diffusion immunoprecipitation assay.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1988

Phase I and II clinical trials with Vicoa Indica (Banjauri), a herbal medicine, as an antifertility agent.

Safety and contraceptive efficacy of Vicoa Indica (Banjauri), a herbal contraceptive, has been evaluated in female subjects for the first time by using modern methods of a clinical trial. The drug, when administered in a dose of 15 gm once a day for 3 days for 3 cycles, was found to be free from side effects and possessed antifertility activity which is dose-related and can be improved upon by modifying the drug delivery system.

Contraceptive Agents, Female↗
PubMed1988

Effect of maternal cardiac disease on perinatal outcome.

Perinatal outcome of 223 pregnancies complicated by maternal cardiac disease, over a 5-year period has been studied. Mean birth-weights of these babies were compared to the Institute's reference neonatal weight curves at different periods of gestation and found lower than the reference. The mean difference of 150 g was statistically significant. The incidence of prematurity, small for gestational age and perinatal mortality was analyzed according to the risk factors i.e. type, duration and severity of symptoms. The perinatal outcome was directly proportional to the severity of symptoms, irrespective of the type and duration of heart disease.

Adult↗
PubMed1987

Childbirth following primary cesarean section--evaluation of a scoring system.

Of 1184 cases with previous cesarean section, 590 were selected for trial of vaginal delivery and 594 for repeat cesarean section. Of the former group, 76.6% had successful vaginal delivery. Incidence of uterine wound dehiscence and of perinatal mortality was highest in cases with primary classical cesarean section. Factors like indications for previous cesarean section, history of intercurrent vaginal delivery, weight of baby and period of gestation had positive correlation with delivery outcome.

Cesarean Section↗
PubMed1987

Congenital absence of the vagina--simple surgical procedure for its relief.

A modified method of treatment of congenital absence of the vagina with the use of amnion graft has been explained with illustrations. Follow-up of 20 patients treated with this method showed successful results without any postoperative cicatrization provided the marital relationship was started within 6-8 weeks.

Adolescent↗
PubMed1987

Evaluation of preinduction scoring systems.

Two hundred patients requiring induction of labour were assigned a preinduction score according to Dhall's criteria and Bishop's criteria. A score of 9 or more (Dhall) and 6 or more (Bishop) had favourable outcomes with successful induction in more than 90% of patients and an induction delivery interval (IDI) of less than 12 hours. In multiparas a Dhall score of more than 7 had a sensitivity and specificity of 88.6% and 90.0% respectively in predicting induction outcome compared to Bishop score sensitivity of 86.3% and low specificity of 47.4%. Correlation of the score with IDI as a dependent variable also showed that the Dhall score had a better predictive value than the Bishop score.

Cesarean Section↗
PubMed1986

Spontaneous cholesterol movement between lipid vesicles and monkey small intestinal brush border membrane.

[14C]Cholesterol movement between egg phosphatidylcholine-cholesterol lipid vesicles and vesicles prepared from monkey small intestinal brush border membrane (BBMV) was studied in physiological buffer at 37 degrees C. The rate of cholesterol transfer from sonicated unilamellar vesicles (ULV) to BBMV follows apparently first-order kinetics. Intermembrane cholesterol movement was strikingly similar in both the directions. However, from BBMV to ULV, the transfer rate was three times faster than that of ULV to brush border membrane (BBM). Similarity in the rate constant was observed when cholesterol transfer was studied using either large multilamellar lipid vesicles or ULV as the donor and BBMV as the acceptor membrane. Rate constant was also the same when the acceptor membrane used was either intact BBMV or ULV prepared from BBM lipids. The rate of transfer of label was not affected even when the acceptor vesicle concentration was increased over fivefold, indicating the first-order nature of the reaction. Transfer of cholesterol from ULV to BBMV was accelerated by the presence of acetone, dimethyl sulfoxide (DMSO), deoxycholate, and papain. Partially purified nonspecific lipid-exchange protein increased the rate of cholesterol transfer by about threefold. Reduction in BBM cholesterol and phospholipid content was noted by DMSO, acetone, and deoxycholate, while papain caused a small depletion of membrane protein. Cholesterol transfer is temperature dependent with an activation energy of 31 kJ X mol-1, which is almost identical in the presence or absence of nonspecific lipid-exchange protein. The molecular mechanism of intermembrane cholesterol movement is discussed in view of the kinetic data obtained.

Animals↗
PubMed1986

Problems of rudimentary horn pregnancy.

Five cases of rudimentary horn pregnancy are discussed. Two presented as acute ruptured ectopic pregnancy, whereas in 3 the pregnancy was advanced and intact with intrauterine death of the fetuses. The diagnostic difficulties are discussed and in centres where ultrasound facilities are not available, a high index of suspicion in nonresponders to oxytocin induction is emphasized.

Adult↗