[Demonstration of the role of the idiotypic system in the physiopathology of autoimmune manifestations in Mycoplasma pneumoniae infections].
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Adhesins, Bacterial↗
Biomedical subjects
K Dellagi
Publications and source records attributed to K Dellagi.
[Immunochemical analysis of human monoclonal IGM with antibody cold agglutinin activity during Mycoplasma pneumoniae infection].
Mycoplasma pneumoniae (MP) infection is associated with the emergence of anti-I cold agglutinins of IgM isotype, rarely complicated by hemolytic anemia. The mechanism by which the autoimmune disease occurs is still considerably controversed. We describe here a case of MP infection complicated by severe autoimmune hemolytic anemia with monoclonal anti-I IgM. IgM anti-I antibodies were purified by adsorption-elution on OI+ red cells. The red blood cell antibodies were found to be tightly associated with IgG and anti-MP specificity probably as immune complexes. The significance of these results is discussed.
Anemia, Hemolytic, Autoimmune↗