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Biomedical subjects

K C Bergmann

Publications and source records attributed to K C Bergmann.

At least 127 records · Page 7Linked to original sources
PubMed1976

[Functional analysis in experimental respiratory distress syndrome (author's transl)].

After injection of an anti-lung -serum a respiratory distress syndrome could be produced in spontaneously-breathing guinea pigs. Reduced compliance, increased resistance and work of breathing was found. Morphological investigations showed intraalveolar and interstitial bleedings and a lung edema. Biochemically a decreased total phospholipid content could be found. Surface tension characteristics, examined with the Langmuir balance, were deteriorated. A complete restitution of surface tension parameters and total phospholipid content was obtained by administration of bromhexin metabolit Na 872.

Animals↗
PubMed1976

[Quantitative determination of alpha1-antitrypsin in lung tissue from adults with emphysema and newborns with respiratory-distress-syndrome (author's transl)].

In a small number of patients, lung emphysema can be attributed to a remarkable deficiency of alpha1-antitrypsin. Concentrations reduced about 50% of the normal value represent a predisposing factor. In most cases of newborns with respiratory-distress-syndrome the concentration of alpha1-antitrypsin is decreased. Its determination can be used for the early diagnosis of the respiratory-distress-syndrome.

Adult↗
PubMed1976

[Possibilities of the immunological in vitro-diagnostic in nonspecific lung diseases (author's transl)].

Immunological in vitro-methods can be used in the improved diagnostic of nonspecific lung diseases. A short review is given about the recommended tests in the diagnostic of the four types of immunological reactions responsible for allergic disorders of the lungs (IgE-mediated immediate-reaction, cytotoxic-reaction, Arthus-reaction and cell-mediated hypersensitivity), the alpha1-antitrypsin deficiency and the immunological defence in the bronchial mucosa.

Bronchi↗
PubMed1976

[Immunological aspects in lung diseases (author's transl)].

The immunological aspects of allergic disorders of the lung (Type I-IV by Gell and Coombs, drug hypersensitivity, auto-immune diseases) and non-allergic lung diseases (emphysema in alpha 1-antitrypsin deficiency, bronchial carcinoma) are described. The short review is closed with remarks about the immunological defence in the bronchial mucosa.

Anti-Glomerular Basement Membrane Disease↗
PubMed1976

[Experimental model of bronchial asthma (author's transl)].

Allergic asthma-like attacks were induced in guinea pigs by intraperitoneal injections of Ovalbumin and following inhalation of Ovalbumin aerosol. The animals were narcotized, tracheotomized and a small catheter was placed in mid-oesophagus. The quantities: oesophageal pressure, respiratory flow and tidal volume were measured and recorded on magnetic tape during spontaneous breathing. A technique was applied for automated computation of the parameters of respiratory mechanics using a digital computer. The parameters compliance, resistance, work of breathing and power of breathing showed typical pathological variances and characteristic response-curves in the experimental phases during and after the asthma attacks. These parameters became normal after the injection of Alupent.

Animals↗
PubMed1976

[The influence of rifampicin on the lymphocyte stimulation (author's transl)].

In 7 PHA--and PPD stimulated lymphocyte cultures from healthy human donors the maintained immunosuppressive effect of Rifampicin was investigated. Concentrations of 5-200 mug RMP/ml culture medium were used. A significant decrease in the transformation rate was found at 20 mug/ml and higher concentrations. A vitality examination (trypan blue staining) on lymphocytes after 72 hours cultivation in a RMP-containing medium with the same concentrations showed no increase of stained cells as compared with the controls. It is suggested that the observed inhibition of lymphocyte reactivity is to be attributed to an immunosuppressive effect of RMP and not to a toxic influence.

Cells, Cultured↗
PubMed1976

[The appearance of surface-active phospholipids of the surfactant-system of the lung during ontogenetic development of humans (author's transl)].

In order to characterize the pulmonary maturity during ontogenetic development the following parameters were determined in the lungs of 30 fetuses respectively newborns with a weight between 15 and 4450 g: Water content (WC), total phospholipid content (TPC), lecithin concentration (LC), sphingomyelin concentration (SPC) and surface activity (SA) of the extracts. The water content decreases with increasing gestation age. The total phospholipid content and the lecithin concentration increase during the ontogenetic development. The sphingomyelin concentration remains approximately constant during lung development. No significant correlation exists between phospholipid content and surface activity. A relatively high TPC and a high SA was found in a 43 g-fetus (about 14th week of gestation). This result suggests, that the surfactant-system of the lung is produced earlier than supposed till now. Lungs of infants who developed respiratory distress syndrome (RDS) have a low concentration of TPC. The lecithin/sphingomyelin-ratio rises as gestation progresses. Lungs of RDS-children have - similarly in amniotic fluid - a low lecithin/sphingomyelin-ratio.

Female↗
PubMed1975

Immunologic differentiation of proteins in the surfactant system of the lung.

Immunoelectrophoresis revealed the following four protein components in the lung surfactant system of guinea-pigs: albumin, transferrin, IgG, and an organ-specific protein migrating in the beta-globulin range. These proteins probably take part in the formation of the hypophase of the alveolar lining layer and thereby influence the surface properties of the alveolar air-liquid interface.

Albumins↗