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Biomedical subjects

K Bork

Publications and source records attributed to K Bork.

At least 109 records · Page 6Linked to original sources
PubMed1980

[Massive upper gastrointestinal bleeding as first clinical manifestation of pseudoxanthoma elasticum (author's transl)].

We describe a patient with a "cryptogenic" massive upper gastrointestinal bleeding due to a pseudoxanthoma elasticum, recognized only postoperatively. She underwent twice emergency abdominal surgery with total gastrectomy and partial jejunal resection, with a complicated postoperative course. An insufficient enteral anastomosis was perhaps caused by deficient reapir mechanisms of the involved organs due to the underlying disease. Pseudoxanthoma elasticum, an hereditary degenerative disease of especially the elastic connective tissue, involves primarily the vascular system, skin, and eyes, with the typical complication of massive gastrointestinal bleedings. Instead of surgical intervention, such bleedings should be treated preferably by utmost application of conservative means.

Adult↗
PubMed1980

[Dermatological aspects of Hildegard von Bingen's work].

In many ways Hildegard von Bingen was honoured in 1979 in memory of the 800th anniversary of her death. Hildegard was not only the mystical visionary and prophetess of the middle ages, she was for her time also a practical thinking physician with an enormous scientific knowledge. In her books "physica" and "causae et curae" numerous clinical pictures of dermatological diseases are described as well as therapeutical advices given which offer a wide insight into the knowledge of skin diseases of this period of monastery medicine.

Bloodletting↗
PubMed1980

[Cardiac involvement in urticaria].

Cardiac involvement in patients with urticaria is rare, but repeatedly assured in publications. Subjective complaints concern chest pain, which extends to the left shoulder and the left arm. Transient electrocardiographic changes can be observed more frequently and they often persist longer than the ches pain. In these patients the most frequent electrocardiographic changes consist in flattening or inversion of the T-wave and depression of the ST-distance. Such a patient is described who additionally showed monotopic extrasystoles.

Adult↗
PubMed1979

[Histamine levels in interstitial fluid of lesional and perilesional skin in patients with chronic idiopathic urticaria (author's transl)].

In 8 patients with idiopathic chronic urticaria suction blisters were produced simultaneously on lesional and perilesional skin in the periumbilical area without application of heat. The suction pressure was 250 mm Hg, and thus the blister production lasted from 60--120 min. The blister fluid histamine was determined with a modified autoanalyzer technique developed by Siraganian. In this method the extractionof histamine, the condensation of o-phthaldial-dehyde with histamine and the measurement of the fluorochrome is automated. With the described method it is possible to measure values less than 0.5 ng/ml. Histamine levels in perilesional skin were nearly in the same range as in the periumbilical skin of 10 normal persons. The range of the normal tissue fluid histamine levels was 0--15 ng/ml and they did not differ significantly from the plasma levels. In all 8 patients with chronic urticaria the histamine values were higher in lesional than in perilesional skin. In 1 patient the lesional blister fluid histamine value reached 35.5 ng/ml. Four of the patients showed only low differences (less than 3 ng/ml).

Autoanalysis↗
PubMed1979

[Vasculitis racemosa hemoplegica].

The secondary symptomatic forms of livedo reticularis can follow cerebrovascular incidents with consecutive hemiplegia; this is rarely known. A further patient is described who developed an asymmetrical livedo reticularis on the hemiplegic half of the body. The reason of the hemiplegia was an intracerebral hemorrhage.

Adult↗
PubMed1979

[Formaldehyde in hair shampoos].

In most hair shampoos commercially available in Western Germany formaldehyde or formaldehyde liberating substances serve as efficient preservatives especially in shampoos of the lower price group. Besides, PHB-ester, mercury containing substances and since recently brome compounds are used for this purpose. We observed a 15 year old patient who developed an allergic contact dermatitis from formaldehyde in a hair shampoo. However, compared to the widespread opportunities of exposure allergic contact dermatitis caused by hair shampoos is not very frequent. For this rarity of formaldehyde dermatitis caused by shampoos the short period of application and the low concentration because of the high dilution and perhaps the low contact dermatitis reactivity of the scalp are responsible. After all only two out of thirtyone thoroughly questioned patients, who had acquired a professional formaldehyde sensitivity elsewhere, reported a contact dermatitis caused by shampoos, which by the way appeared in the orbital region as typical. Probably allergic contact dermatitis from formaldehyde in shampoos will be expected in patients with a formaldehyde sensitivity acquired formerly elsewhere, especially professionally. To those patients formaldehyde free hair shampoos should be recommended. The declaration of formaledehyde in cosmetics, which will be legally obligatory in Germany in 1979, will be valuable for finding out the alternate products free of formaldehyde.

Adolescent↗
PubMed1978

[Physical forces in blister formation. II. Examination of total osmolality in blister fluid of suction blisters, "naturally" developed blisters and in serum (author's transl)].

Total osmotic pressure does not differ significantly in suction blister fluid or in serum of healthy persons from blister fluid, suction blister fluid or serum of patients with dermatitis herpetiformis, bullous contact dermatitis and pemphigus vulgaris. The average values reach about 293 mOsmol/kg. This results from direct measurement of total osmolality with an electronic semimicroosmometer based on the principle of freezing point reduction. In opposite to colloid osmotic pressure the total osmotic pressure does not take part in blister formation of human skin in spite of the different concentrations of the single electrolytes in the fluids of various blisters.

Blister↗
PubMed1978

Physical forces in blister formation. The role of colloid osmotic pressure and of total osmolality in fluid migration into the rising blister.

The physical forces operative in the fluid migration from the interstitial spaces into the blister cleft have not been directly measured until now. The colloid osmotic pressure and the total osmolality were determined in suction blister fluid after mild suction blister production by a modified "Dermovac" and in blister fluid of patients with dermatitis herpetiformis, bullous allergic contact dermatitis and pemphigus vulgaris and in the sera of healthy persons. The colloid osmotic pressure was measured by means of a recently developed osmometer with a semipermeable membrane between 2 chambers, one of them filled with Ringer solution, the other with the blister fluid or serum sample. The negative pressure in the first chamber was determined. The colloid osmotic pressure of suction blister fluid averages approximately 7 cm H2O, the values reach about 20 cm H2O in bullous diseases and about 38 cm H2O in the normal sera. The blister fluid colloid osmotic pressure has to rise to about 15 cm H2O or more to cause the fluid transport from the interstitial spaces of the surrounding tissue into the blister because of the negative interstitial fluid pressure and the colloid osmotic pressure of the interstitial fluid. Otherwise the blister fluid is reabsorbed back into the interstitial spaces. The total osmolality does not differ in the serum and in the blister fluid. It does not seem to be etiologically connected with the fluid transport into the rising blister.

Blister↗
PubMed1978

[Juvenile papulous dermatitis].

Juvenile papular dermatitis is a rare and harmless disease of childhood, which is scarcely known in Germany. The clinical and histological signs of the disease are described and a case of a 6-year-old patient is presented. In most patients the clinical difference of the other numerous papular eruptions of childhood and etiological aspects are discussed.

Age Factors↗
PubMed1978

[Physical bases of blister formation. II. A study of the total osmotic pressure in the blister fluid of suction blisters and of "naturally" occurring blisters as well as in the serum].

Total osmotic pressure does not differ significantly in suction blister fluid or in serum of healthy persons from blister fluid, suction blister fluid or serum of patients with dermatitis herpetiformis, bullous contact dermatitis and pemphigus vulgaris. The average values reach about 293 mOsmol/kg. This results from direct measurement of total osmolality with an electronic semimicroosmometer based on the principle of freezing point reduction. In opposite to colloid osmotic pressure the total osmotic pressure does not take part in blister formation of human skin in spite of the different concentrations of the single electrolytes in the fluids of various blisters.

Biophysical Phenomena↗