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Biomedical subjects

K Beyreiss

Publications and source records attributed to K Beyreiss.

At least 55 records · Page 3Linked to original sources
PubMed1986

Bile acids in the serum and duodenal content of newborn infants of different classification.

Total serum bile acids were determined in 83 infants of different classification. In 33 mature infants total bile acids were measured after feeding human milk (n = 17) or formula (Milasan). Statistically significant elevations of total bile acids were found on the 14th day of life, if mature infants were formula fed. In low-birth-weight infants appropriate for gestational age total bile acids are not higher on the 8th day of life than in mature infants, but on the 14th day of life the elevations become significant. Low-birth-weight infants small for gestational age and infants suffering from fetal distress syndromes show the highest total bile acids with great variations. Low-birth-weight infants small for gestational age had serum total bile acid concentrations related to the degree of fetal growth retardation (r = -0.871). Some newborns suffering from late metabolic acidosis had lowest intraluminal total bile acids, especially dihydroxy bile acids. We found a direct hyperbolic dependence between total bile acids in the serum and the duodenal content (r = +0.93). In cases of serum total bile acids above 50 mumol/l, concentrations in duodenal content do not exceed 2 mmol/l. Therefore, the degree of fetal growth retardation, fetal distress syndromes, and the nutrition after birth have great influence on bile acid metabolism.

Aging↗
PubMed1985

Digestion and absorption rates of lactose, glucose, galactose, and fructose in three infants with congenital glucose-galactose malabsorption: perfusion studies.

The digestion rates of lactose and the absorption rates of glucose, galactose, and fructose were studied by continuous perfusion of the jejunum in three patients aged 7 weeks to 9 months with congenital glucose-galactose malabsorption (infusion rate:1.0 ml min-1; concentration of each sugar: 200 mM; perfusion distance: 30 cm). The mean absorption rates of glucose and galactose were 26.5 and 43.8 mumol min-1 30 cm-1, respectively, and were significantly reduced (p less than 0.001) to 13 and 22%, respectively, of intake. On the other hand, the absorption of fructose was 133.3 mumol min-1 30 cm-1, i.e., as high as in the controls. The hydrolysis rate of lactose was also normal (134.0 mumol min-1 30 cm-1). However, the absorption rates of glucose and galactose released from the disaccharide were as low as the perfusion of free monosaccharides. In patients with glucose-galactose malabsorption the glucose absorption rate is as low as that of galactose. No additional glucose transport system seems to exist. A hydrolase related transport system is also of no importance in compensating for the primary defect of monosaccharide absorption.

Biological Transport, Active↗
PubMed1985

[Protein metabolism in the small for gestational age newborn in relation to the severity of fetal malnutrition].

The daily nitrogen balance, the amino acid concentrations in serum and urine, and the bile acid concentrations in the serum on the eighth day of life were estimated in newborn infants small for gestational age with different degrees of fetal malnutrition. The amino acid concentrations in urine and serum as well as the total nitrogen losses by urine increase in dependence on the severity of fetal malnutrition. In addition the bile acid concentrations were elevated whereas the urea concentrations in serum remained unchanged. These results point to a deranged liver function which depends on the degree of fetal malnutrition. These special metabolic conditions have to be considered in the nutrition of such infants. The bile acid concentrations seem to be an efficient parameter to estimate this metabolic situation.

Amino Acids↗
PubMed1985

Nutrition of newborns small for gestational age with human milk lyophilisate enriched human milk during the first week of life.

In 24 very low birth weight infants appropriate or small for gestational age, the metabolic response to nutrition with human milk lyophilisate enriched human milk was estimated during the first week of life. In contrast to newborns appropriate for gestational age, in newborns small for gestational age signs of metabolic overloading could be observed: increased urinary amino acid excretion and neonatal cholestasis. Both depended on the degree of fetal growth retardation. It was concluded that nutrition with human milk lyophilisate enriched human milk cannot be recommended for very low birth weight infants during the first week of life. In newborns small for gestational age the metabolic situation has to be estimated before starting a high protein diet. If the level of total bile acids amounts to more than 30 mumol/l, protein intake should be increased carefully during the first week of life.

Amino Acids↗
PubMed1984

[Glomerular filtration in low birthweight neonates].

The glomerular filtration rate (GFR) was estimated in mature newborns appropriate for gestational age (AGA), mature newborns small for gestational age (SGA) and premature newborns AGA on the 2nd day and the end of the 3rd week of life. The GFR was determined by mannitol using the slope-clearance technique. On the 2nd day the GFR is significantly diminished in mature newborns SGA (1.21 ml/kg X min) compared to mature newborns AGA (1.84 ml/kg X min) as well as premature newborns AGA (1.54 ml/kg X min). During the first 3 weeks of life the GFR increases significantly in mature newborns both AGA (2.20 ml/kg X min) and SGA (1.65 ml per kg X min), whereas the increase is insignificant in premature newborns AGA (1.70 ml per kg X min). Therefore there is no difference between mature newborns SGA and premature newborns AGA at the end of the 3rd week of life. The decreased GFR of newborns SGA during the first weeks of life has to take into consideration for dosage of drugs tending to cumulate and for composition of parenteral nutrition.

Glomerular Filtration Rate↗