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Biomedical subjects

K Balogh

Publications and source records attributed to K Balogh.

At least 73 records · Page 4Linked to original sources
PubMed1985

Silicone granulomas: report of three cases and review of the literature.

Since silicone is rapidly becoming one of the most commonly used biomaterials in modern medicine, pathologists will be observing increasing numbers of cases of silicone-related disease. Although numerous case reports have established that silicone elicits a characteristic response in tissues, the varying tissue reactions to silicone gels, liquids, and elastomers (rubber) have not been emphasized. Three cases are reported, and the literature is reviewed to illustrate the varying features of tissue reaction to silicone in its different forms. The first case is an example of silicone lymphadenopathy in an inguinal lymph node. This case demonstrates exuberant foreign body granuloma formation in response to particles of silicone elastomer. The second case involves a patient who had facial subcutaneous liquid silicone injections, and the third case is that of a woman in whom breast carcinoma developed 13 years after mammary augmentation with liquid silicone injections. These two cases illustrate the characteristic reaction to silicone liquid, with numerous cystic spaces and vacuoles in the soft tissues but minimal or no foreign body giant cell reaction. Scanning electron microscopy and energy dispersive x-ray analysis were performed in the first two cases, confirming the presence of silicon. Silicone migration and the clinical significance of various silicone-induced lesions are discussed.

Adult↗
PubMed1985

Benign vascular invasion in vasitis nodosa.

Vasovasostomy specimens were examined for vascular changes in 50 cases of vasitis nodosa. In five, benign gland- or ductule-like structures were seen invading small veins and, in one, also the small arteries. The intravascular ductules appeared benign, and there was no clinical evidence of malignancy. The presence of ductules in the blood vessels always was accompanied by marked elastosis. In 12 additional cases, elastosis of arteries and veins was seen without intravascular ductules. These changes suggest that proliferating ductules in vasitis nodosa invade the blood vessels after they have become obliterated by regressive and reparative processes.

Adult↗
PubMed1985

Induction of graft-versus-host disease by small intestinal allotransplantation in rats.

Adult male (LewisXBrown Norway) F1 (LBNF1) rats received heterotopic small intestinal transplants from Lewis donors. Lewis-to-Lewis and LBNF1-to-LBNF1 isografts served as controls. All of the allograft recipients died after a median survival time of 16.2 days, but all isografted rats survived indefinitely. During the period of deterioration, allografted rats developed marked cutaneous erythema and became increasingly weak and cachectic. Histological changes of the skin, spleen, and grafts were characteristic of graft-versus-host disease (GVHD). There was a marked degree of relative splenomegaly. Injection of spleen cells obtained from LBNF1 rats with clinical GVHD into the foot-pad of syngeneic LBNF1 rats resulted in significant enlargement of the ipsilateral popliteal lymph node. The degree of lymph node enlargement was comparable to that induced in LBNF1 rats by injection of normal Lewis spleen cells. These results clearly demonstrate the ability of the small intestinal allograft to cause rapid and fatal GVHD in rats that are incapable of graft rejection.

Animals↗
PubMed1985

Vasitis nodosa and spermatic granuloma of the skin: an histologic study of a rare complication of vasectomy.

A 29-year-old man noticed localized painful swelling of the scrotal skin after elective vasectomy. The lesion was excised and its histologic examination revealed a diffuse inflammatory, partly granulomatous infiltrate with numerous tubular structures in the dermis and subcutaneous tissues. These ductules were lined by cuboidal epithelial cells and contained spermatozoa. The inflammatory infiltrate consisted of lymphocytes, plasma cells and histiocytes, but also contained spermatozoa and a few spermatic granulomas. These changes were the sequelae of a vasocutaneous adhesion and fistula; the ductules were the result of epithelial regeneration from the vas deferens and the inflammation with spermatic granulomas was due to extravasated spermatozoa.

Adult↗
PubMed1985

Aortic valvular tophus: identification by X-ray diffraction of urate and calcium phosphates.

A typical gouty tophus with birefringent, dichroic, needle shaped crystals was found in a resected calcified aortic valve on routine histological examination. The patient, an elderly man, had a long history of gout. X-ray diffraction confirmed the presence of sodium acid urate monohydrate and identified hydroxyapatite and whitlockite in the accompanying dystrophic calcification of the aortic valves. Previous reports indicate that gouty tophi of the cardiac valves are rare: of the nine cases reported, eight occurred in the mitral valve.

Aged↗
PubMed1985

Carcinoma of the parotid gland with osteoclastlike giant cells. Immunohistochemical and ultrastructural observations.

We describe an unusual type of carcinoma of the parotid gland in a 67-year-old man. Because of rapid tumor growth, radical parotidectomy was done. Light microscopic study of the tumor revealed focal gland formation with transition to anaplastic carcinoma. Among the undifferentiated mononuclear cells and bizarre large cells were scattered many osteoclastlike multinucleated giant cells. Immunohistochemical studies on paraffin sections revealed positive staining for epithelial membrane antigen in the epithelial component; however, the multinucleated giant cells were clearly negative for this antigen. Reactions for other cell constituents (carcinoembryonic antigen, alpha 1-antitrypsin, alpha-1-antichymotrypsin, Leu-M1, Leu-M3, lysozyme, and factor VIII-related antigen) were negative in both epithelial and giant cell components of the tumor. Electron microscopy revealed poorly formed cell junctions and numerous microvilli on the surface of the mononuclear tumor cells and multinucleated giant cells, features considered not of diagnostic significance. Similar to carcinomas with osteoclastlike multinucleated giant cells in other organs, this parotid gland tumor has shown clinical and morphologic evidence of aggressive growth; pulmonary metastases developed and the patient died 28 months after radical surgery.

Aged↗
PubMed1985

Tenosynovial osteochondroma of the hand. A case report and brief review.

A 61-year-old man presented with a slowly growing, painless mass over the dorsum of his right hand. Roentgenography, computed tomography, and a radionuclide bone scan revealed a soft-tissue mass with mineralization but no bone or joint involvement. Routine laboratory tests and a chest roentgenogram were negative. A biopsy was inconclusive. The mass was removed en bloc and was diagnosed as synovial osteochondroma arising from the extensor tendon sheaths. The patient has been symptom-free 16 months postoperation. The literature indicates that these tumors occur almost exclusively in the hands or feet and are thought to develop by metaplasia from the mesenchymal cells of the synovial membrane; mineralization and ossification of the tumor are secondary. The actively growing tumor is often cellular and may show atypical cytologic features. Such microscopic characteristics should not be interpreted as evidence of a low-grade chondrosarcoma. A review of the literature failed to disclose a case with malignant transformation, although several lesions had recurred, some more than once. For this reason, complete removal of the involved synovia is of great importance.

Chondroma↗
PubMed1984

The frequency of perineurial ductules in vasitis nodosa.

In a retrospective histologic study, 154 vasovasostomy specimens (77 patients) yielded 50 examples of vasitis nodosa. These cases were examined for nerve invasion by proliferating ductules; benign neural invasion was present in four instances, and four additional cases were found on step sectioning the vasovasostomy specimens, totaling eight cases (16%) of the 50 studied. Usually only one or two nerves were invaded. The number of glands within individual nerves varied from one to eight. The findings are discussed in the context of benign glandular invasion of nerves in other locations.

Adult↗
PubMed1984

Palisading prostate granulomas following surgery.

Fifteen cases of palisading granulomas of the prostate occurring in patients with a history of previous prostate surgery are described and illustrated. This distinctive histologic lesion strongly resembles a rheumatoid nodule, but is not associated with connective tissue disease or infection and is probably related to prior transurethral prostatectomy or needle biopsy.

Aged↗
PubMed1984

Pulmonary bile emboli. Sequelae of iatrogenic trauma.

A 58-year-old man manifested obstructive jaundice secondary to adenocarcinoma of the common hepatic duct. The markedly icteric patient underwent multiple diagnostic and therapeutic procedures, including percutaneous needle biopsy of the liver, curettage, catheterization and washing of the hepatic ducts, and percutaneous transhepatic cholangiography. Three months later the patient died of a bleeding gastric ulcer. Autopsy confirmed the presence of adenocarcinoma of the common hepatic duct. Microscopic examination of the lungs disclosed numerous bile emboli in the smaller arteries, arterioles, and in a few alveolar capillaries. Histochemical reaction of the emboli was positive for bilirubin. Organizing fibrin was seen around occasional bile emboli, but most were without microscopic reaction. Review of the literature disclosed nine cases of pulmonary bile embolism, six of which had a history of marked cholestasis and trauma to the liver, like the present patient. Bile reaches the systemic circulation through a biliary-venous fistula that, in our case, was probably iatrogenic.

Adenocarcinoma↗
PubMed1984

Cardiac neurilemoma. Report of a case with electron microscopic examination.

A cardiac neurilemoma was found at autopsy in a 70-year-old man. The patient had an adenocarcinoma of the lung with metastases to hilar lymph nodes and various organs. Light microscopic examination showed a small nodule of metastatic adenocarcinoma in the cardiac neurilemoma. Electron microscopic examination confirmed the Schwann's cell origin of the cardiac tumor. To our knowledge, this is the fifth reported case of cardiac neurilemoma.

Adenocarcinoma↗
PubMed1980

Crohn disease of penile and scrotal skin.

Genital cutaneous involvement with Crohn disease is an uncommon complication which has been described only recently. A case is presented of a young man with Crohn disease involving the penile and scrotal skin four years after total colectomy for Crohn disease. The histopathology and management are discussed. While the complications of Crohn disease vary in the literature, we believe involvement of the skin of the genitalia is uncommon.

Adult↗
PubMed1977

Monoclonal macroglobulinemia with osteolytic lesions: a case report and review of the literature.

A patient with monoclonal macroglobulinemia and osteolytic lesions was studied and 24 previously reported closely related cases were reviewed. Cases studied by ultracentrifugation without an immunoelectrophoresis were not considered. Patients presenting with a primary increase in monoclonal IgM molecules may be divided into three groups: typical Waldenstrom's macroglobulinemia, macroglobulinemia with osteolytic lesions resembling multiple myeloma, and a group displaying features of both diseases. At present, cell morphology is not helpful in separating these groups, and a bone survey is recommended. The authors underscore the clinical importance of the early recognition of these entities since procedures such as plasmapheresis for the management of hyperviscosity syndrome, mobilization and local radiotherapy to symptomatic lytic lesions may be necessary for optimal management.

Adult↗
PubMed1976

Testicular reaction to prolonged exposure to nitrous oxide.

Male LEW/f Mai rats were exposed to an atmosphere of 20 per cent N2O, 20 per cent O2, and 60 per cent N2 for a maximum of 35 days. Evidence of injury to the seminiferous tubules was found in some animals by the second day. By 14 days, such damage was found in all animals. The toxic effect was confined to the spermatogenic cells, with consequent reduction in mature spermatozoa and appearance of multinucleated forms. Other cells within the testes were resistant to damage. Recovery of spermatogenesis occurred after return to room air for more than three days. Serum testosterone levels were not significantly affected during the prolonged exposure.

Animals↗