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Biomedical subjects

K Aso

Publications and source records attributed to K Aso.

At least 109 records · Page 6Linked to original sources
PubMed1990

Cerebral infarcts and seizures in the neonate.

A retrospective analysis was performed on 54 infants who suffered perinatal hypoxic-ischemic insults and came to autopsy, in an attempt to assess the association of cerebral infarcts with seizures. Fifty infants had several types of cerebrovascular lesions, including intraventricular hemorrhage (32 cases), periventricular leukomalacia (24), ischemic neuronal necrosis (18), pontosubicular necrosis (12), cerebral infarct (9), and cerebellar hemorrhage (7). Of these infants, nine had electroencephalographic seizures. Among a variety of cerebrovascular lesions, cerebral infarcts represented the single lesion most highly correlated with seizures. The incidence of seizures in infants with cerebral infarcts (44%) was significantly higher than with other types of vascular lesions.

Asphyxia Neonatorum↗
PubMed1990

Punctate porokeratotic keratoderma: some pathogenetic analyses of hyperproliferation and parakeratosis.

An 82-year-old Japanese woman had numerous palmoplantar keratotic plugs and pits, resembling 'music box spines'. Histological examination revealed compact columns of parakeratosis in the horny layer. Ultrastructually, the affected stratum corneum contained numberous variable-sized pyknotic nuclei, and cells in the stratum granulosum contained fewer keratohyalin granules. Autoradiographic analysis by [3H]thymidine [3H]TdR incorporation into epidermal cells of affected skin slices in organ culture revealed that only basal cells below the keratotic plug were stimulated to proliferate. Two-dimensional gel electrophoresis revealed that palmar keratotic plugs contained the keratin filaments that are specifically present in the plantar viable epidermal layer, or other hyperproliferative epithelial cells.

Aged↗
PubMed1990

[Rothmund-Thomson's syndrome--a case demonstrating prominent hyperkeratosis and literature review].

A patient, 21-year-old japanese man demonstrating many of the changes seen in the Rothmund-Thomson's syndrome is presented. In particular the hyperkeratosis palmo-plantar hyperkeratosis and warty hyperkeratosis on the hand and feet are prominent clinical features in this patient. The literatures describing hyperkeratosis in the Rothmund-Thomson's syndrome are reviewed and the clinical feature as well as diagnostic value of the hyperkeratosis is discussed.

Adult↗
PubMed1990

[Suspected germ cell tumor in bilateral basal ganglia with progressive dystonia].

We report an 11-year-old boy with left pyramidal signs followed by progressive dystonia, mental deterioration, bradykinesia and bradyarthria. Evaluation included a CT scan which showed bilateral lesions in the basal ganglia, and an elevated serum B-HCG. Those findings suggested a germ cell tumor. The patient was treated with radiation therapy with improvement in neurologic deficits, decreased size of the lesions on CT and a decline in serum B-HCG. The clinical response to radiation treatment is compatible with a germ cell tumor.

Basal Ganglia Diseases↗
PubMed1990

[Three cases with electrocardiographic changes suggesting myocardial infarction].

We had three cases that showed electrocardiographic changes suggesting myocardial infarction during or soon after operation. All cases were elderly for open abdominal operation complicated with carcinoma or infection. They were different from typical myocardial infarction in progress of electrocardiographic changes, increase of myocardial enzyme, autopsy and so on. Kuramoto et al. reported in some cases myocardial infarction could not be recognized at autopsy in spite of electrocardiographic changes suggesting myocardial infarction during gastric operation of the elderly, and they advocated an idea of "reversible myocardial infarction". These three cases were also thought to be consistent with this disorder.

Aged↗
PubMed1990

[Left atrial thrombosis after mitral valve replacement].

Thrombosis of the left atrium is a rare but troublesome complication of the mitral valve replacement (MVR). In our series of MVR, seven patients had thrombus formation of the left atrium late after MVR. These seven cases (LAT group) are compared with 53 cases (no LAT group), who are picked up randomly and have no thrombus of the left atrium after MVR, concerning to some risk factors. And the result is that the left atrial volume shows a significant difference between two groups among the risk factors. We consider that the cases with enlarged left atrium have a high risk of thrombus formation after MVR and so they also need a plication of the left atrium at the primary operation.

Adult↗
PubMed1990

[Surgical treatment of massive pulmonary embolism--the time of the operation and its effectiveness].

The records of 6 patients undergoing pulmonary embolectomy for massive pulmonary embolism (MPE) at Kurume University Hospital during 17 years were reviewed to determine the management of surgery. The patients consisted of 2 men and 4 women. The patients' ages ranged from 29 to 68 years (mean age, 49.3 years). The records showed that one patient died of brain death after operation and the others survived. All the patients complained of chest pain, anterior chest discomfort and dyspnea. Sudden syncope was observed in 2 patients. Artificial mechanical ventilation was performed preoperatively on 3 patients. Right ventricular load was demonstrated on electrocardiograms and ultrasonograms. Pulmonary angiograms were attempted on two patients and one of them had cardiac arrest during this examination. MPE was suspected by perfusion defect of 50% to 80% of pulmonary vasculature demonstrated on lung perfusion scintigram in 4 patients. Open pulmonary embolectomy with cardiopulmonary bypass (CPB) was performed on all patients using crystalloid cardioplegia and topical cooling. Intraoperative pulmonary angiograms were performed in 4 patients to prevent residual thromboemboli. Since most thromboemboli originate below the level of the vena cava, acute double ligation of the vena cava just below the renal vein was performed to control recurrent embolism. Oral anticoagulant, warfarin, was administered for 3 months after embolectomy as prophylaxis against postoperative recurrent embolism. It is our opinion that an aggressive attitude toward pulmonary embolectomy on CPB is necessary to save lives of MPE patients. This surgical procedure is very easy and safe.

Adult↗
PubMed1989

Neonatal electroencephalography and neuropathology.

One-hundred-eight EEGs from 47 newborn infants were compared with the postmortem neuropathological findings. The degree of EEG background abnormality had good correlation with the severity of the brain lesion; the more severe the EEG background abnormality, the more extensive and intensive the morphological change. Widespread encephalomalacia was demonstrated in six infants who manifested isoelectric tracings. In particular, cerebral cortex, corpus striatum, thalamus, midbrain, and pons were affected in all patients with this abnormal EEG pattern. Burst-suppression patterns, which were seen in seven infants, also correlated with multifocal severe brain damage, but there was no common structure that was consistently affected for all patients with this pattern. Positive rolandic sharp-wave transients (PRS) appeared highly specific for white matter lesions. All eight infants with PRS had white matter lesions. However, the sensitivity of PRS for white matter lesions was not high (32%), and the white matter lesions of PRS-positive patients were not necessarily composed of periventricular leukomalacia. The sensitivity of EEG asymmetry was also low (40%) for the focality of morphological change, although the specificity was relatively high (85%). The origin of seizure discharges, on the other hand, had poor correlation with the site of the brain lesion.

Brain↗
PubMed1989

Characteristics of cytokeratins from stratum corneum of palms.

We have examined cytokeratins from stratum corneum (s. corneum) of the palm and back of hands by biochemical techniques which characterize cytokeratin No. 9 (CK9). By two-dimensional gel electrophoresis, cytokeratins from s. corneum of the palm (PSC) were resolved into three spots (designated as CK-A, CK-B and CK-C by us), and cytokeratins from s. corneum of the back of hands (BSC) were resolved into two spots (CK-A and CK-C). The results of polypeptide mapping and the spot positions in two-dimensional gels suggest that CK-A, CK-B and CK-C are degraded products derived from CK1/2, CK9 and CK10/11 in living keratinocytes of epidermis, respectively. While the spots of CK-A and CK-B were prominent and the spot of CK-C was very weak in PSC, the spots of CK-A and CK-C were prominent and the spot of CK-B was not detected in BSC. In filament reconstitution in vitro, cytokeratins from PSC formed intermediate-sized filaments similar to those commonly observed using cytokeratins from whole epidermis. In contrast, cytokeratins from BSC formed only short filaments and small granules. In order to examine this difference in detail, polypeptides were eluted electrophoretically from gel slices containing spots. Addition of eluted CK-B to cytokeratins from BSC promoted the formation of intermediate-sized filaments similar to those from PSC. Furthermore, although the mixture of eluted CK-A and CK-C did not form intermediate-sized filaments, the combination of CK-A and CK-B alone did form them.(ABSTRACT TRUNCATED AT 250 WORDS)

Hand↗
PubMed1989

A case of tubular apocrine adenoma with syringocystadenoma papilliferum.

We report a new case of a Japanese man who developed a tubular apocrine adenoma in association with syringocystadenoma papilliferum. The differences in the histopathological and immunohistochemical findings in these 2 tumors are described. This is the first immunohistochemical study of tubular apocrine adenoma.

Adenoma↗
PubMed1989

[Long-term follow-up of absence epilepsy].

This study dealt with 58 patients with absence, of whom 46 patients had started with absence and 12 with generalized tonic-clonic seizures (GTCs). Only those patients followed up for more than five years were included, and 30 patients (51.7%) were over eighteen years of age (up to 33). All patients received the present standard medication with ethosuximide and valproate in this study. In each case the diagnosis was confirmed by clinical observation and the typical EEG pattern. A seizure-free interval of at least 1 year was defined as seizure cessation for absence, and a seizure-free interval of at least 2 years for GTCs. Thirty-eight out of 43 patients (88.4%) with absence at onset (group A) and 18 out of 22 (81.8%) older than 18 years became seizure free. Only 8 of 15 (53.3%) patients with initial GTCs (group B) and 5 of 8 (62.5%) over 18 years became seizure free. In all, about 80% of the patients with absence seizures became seizure free as did those who were followed beyond 18 years of age. Out of 15 patients with initial GTCs, 8 of 10 (80%) patients who developed absence seizures later (group B-1) became seizure free, whereas none of 5 patients who had absence and GTC at the same time (group B-2) did. The social status was mainly favorable, even if seizures were uncontrolled. Adequate predictable factors for the development of GTCs were lacking, but the clinical courses in patients of group B-1 resembled those of group A and were rather benign.

Adolescent↗
PubMed1989

[Randomized controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum].

To evaluate of adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer, randomized controlled study by 35 institutions in Kanagawa prefecture was conducted. From March 1985 till February 1987, 462 patients were assigned one of two different regimens. 448 patients (97.0%) of them satisfied the eligibility criteria. Control group received mitomycin C intravenously on the day and the day after the operations respectively followed by 5-FU orally over for 6 months. PSK group received in addition to mitomycin C and 5-FU as in control group, PSK orally for over 3 years. By February 1989, follow up studies of the patients after their operations had been carried out for two years to four years. The disease free curve and the survival curve of PSK group were higher than those of control group, differences between the two groups were statistically significant (Disease free curve: P = 0.0096, survival curve: p = 0.0391). From these results, adjuvant immunochemotherapy with PSK was considered beneficial for curatively resected colorectal cancer.

Adjuvants, Immunologic↗
PubMed1988

The presumption of proteolytic enzymes related to the formation of intermediates during the terminal differentiation.

The [14C]Gly-labelled keratin polypeptides extracted with 1% SDS and 10 mM DTT were made to undergo changes with an enzyme fraction (ammonium sulfate, 50-75% saturated fraction) prepared from a human epidermis in the presence of 1% Triton X-100. In particular, 69-67 kDa peptides were considerably decreased with the above enzyme fraction in the time course experiments, and the components strongly bound to the cell membrane had little effect on the above reaction. In addition, in the case of the [14C]Gly-labelled keratin filament assembly, 69 and 62 kDa peptides were decreased and 55, 52 and 50 kDa peptides were increased with the same enzyme fraction in the time course experiments. From these results, we estimated that the proteolytic enzyme(s) may exist in the human epidermis, and may be processed to keratin intermediates from prekeratin during the initial stage of terminal differentiation in the human epidermis.

Cell Differentiation↗
PubMed1988

Developmental changes of pattern reversal visual evoked potentials.

Analysis of developmental changes in pattern reversal visual evoked potentials (PVEPs) was performed on 141 normal children ranging in age from 1 month to 19 years 4 months. The stimulus was a black and white checkerboard pattern on a television screen, and the check edge subtended 50 min of retinal arc. The major positive peak (P2) was observed in all subjects, and the incidence of other peaks tended to increase with age. The P2 latency decreased rapidly during the first six months of life and reached a constant value after the age of 2 years. The P2 latency with monocular stimulation was significantly longer than that with binocular stimulation in most age groups. Developmental changes of the N1-P2 or P2-N2 amplitudes were unclear, and the standard deviation of the amplitude in each age was too large for clinical application. The P2 latency with binocular stimulation was shorter for females than for males only at the age of 8-11 years.

Adolescent↗