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Biomedical subjects

K Asano

Publications and source records attributed to K Asano.

At least 433 records · Page 24Linked to original sources
PubMed1986

[Effect of menstrual cycle on cardiorespiratory system during incremental exercise].

According to the results of questionnaires to college athletes, they believe the follicular phase is better than luteal phase for competitive sports. However, it is not clear whether there is significant difference in athletic performance between the two phases of the menstrual cycle. The effects of the menstrual cycle on the cardiorespiratory system were investigated in exercising women who are top players of basketball in Japan. They performed incremental exercise on a cycle ergometer. During the exercise, the ECG and heart rate (HR) were monitored. The expired air was sampled continuously and expiratory gas volume/minute (VE), oxygen uptake (VO2), carbon dioxide output (VCO2), gas exchange ratio(R) and respiratory rate (Resp. E.) were measured. Blood samples were collected to measure the blood lactic acid concentration during the exercise. HR in the luteal phase is higher than in the follicular phase at rest and throughout the exercise. VE, R and Resp. R. at rest and during exercise indicated a tendency to a higher level in the follicular phase. The blood lactic acid concentration during exercise in the follicular phase indicated a tendency to increase more rapidly than in luteal phase. However, no statistical differences in the cardiorespiratory system were detected when the follicular and luteal phase were compared. These results did not indicate conclusively in which phase it is better for athletic women to take part in competitive sports.

Adult↗
PubMed1985

A prediction equation for indirect assessment of anaerobic threshold in male distance runners.

The predictability of anaerobic threshold (AT) from maximal aerobic power, distance running performance, chronological age, and total running distance achieved on the treadmill (TRD) was investigated in a sample of 53 male distance runners, 17-23 years of age. The dependent variable was oxygen uptake (Vo2) at which AT was detected (i.e. Vo2 @ AT). A regression analysis of the data indicated Vo2 @ AT could be predicted from the following four measurements with a multiple R = 0.831 and a standard error of the estimate of 2.66 ml . min-1 . kg-1: Vo2max (67.9 +/- 5.7 ml . min-1 . kg-1), 1,500-m running performance (254.5 +/- 14.2 s), TRD (6.82 +/- 1.13 km), and age (19.4 +/- 2.2 years). When independent variables were limited to Vo2max (X1) and 1,500-m running performance (X2) for simpler assessment, a multiple R = 0.806 and a standard error of the estimate of 2.76 ml . min-1 . kg-1 were computed. A useful prediction equation with this predictive accuracy was considered to be Vo2 @ AT = 0.386X1 - 0.128X2 + 57.11. To determine if the prediction equation developed for the 53 male distance runners could be generalized to other samples, cross-validation of the equation was tested, using 21 different distance runners, 17-22 years of age. A high correlation (R = 0.927) was obtained between Vo2 AT predicted from the above equation and directly measured Vo2 @ AT. It is concluded that the generalized equation may be applicable to young distance runners for indirect assessment of Vo2 @ AT.

Adolescent↗
PubMed1985

Wrapped-knitted Dacron and microporous EPTFE conduits for reconstruction of right ventricular outflow tract.

The use of the extracardiac conduit for the right ventricle to main pulmonary artery continuity facilitates repair of a wide variety of complex congenital cardiac malformations. Recently, concern has been directed to the appearance of proliferating and obstructive internal peels. In the present study on 18 mongrel dogs, wrapped-knitted Dacron, expanded polytetrafluoroethylene (EPTFE) and wrapped-knitted Dacron/EPTFE conduits were evaluated in the light of internal linings. Macroscopically, the wrapped-knitted Dacron conduits were covered with a thicker and poorly developed neointima, whereas, EPTFE conduits were internally covered with a thin neointima. Microscopically, the neointima on the former was not well healed, while that of the latter was well developed and anchored. Therefore, the EPTFE conduit seems to be superior to the wrapped-knitted Dacron conduit and EPTFE conduit can be used clinically.

Animals↗
PubMed1985

Erythrocyte membrane abnormalities in patients with amyotrophic chorea with acanthocytosis. Part 1. Spin labeling studies and lipid analyses.

Low fluidity was observed in the erythrocyte membranes of familial chorea-acanthocytosis by spin labeling with 12NS. The high content of the saturated fatty acids support the finding of low fluidity. Other lipid contents (cholesterol and phospholipids) and the cholesterol/phospholipid ratio were within normal ranges. The sharp decrease in the parameter, (h0/h-1)1/2, suggests phase separation deep inside the patients' erythrocyte membrane matrix. This distortion of the membrane matrix may be caused by membrane components other than the lipid components.

Acanthocytes↗
PubMed1985

Erythrocyte membrane abnormalities in patients with amyotrophic chorea with acanthocythosis. Part 2. Abnormal degradation of membrane proteins.

Bands 2.1, 3 and 4.2 of the erythrocyte membrane proteins in chorea-acanthocytosis are self-digested faster than those in normal controls. The junction between spectrin and band 3 protein at the cytoplasmic side of the patients' erythrocyte membranes may have some conformational defects. The conformational defects of the proteins may be responsible for the low fluidity in the interior of the patients' erythrocyte membranes. These basic molecular defects may be widespread in other extraneural cell membranes as well as in neuronal cell membranes.

Blood Proteins↗
PubMed1985

Total cavopulmonary shunt with replacement of common atrioventricular valve for an infant with single atrium and single ventricle.

A 22-month-old male infant with single atrium, single ventricle, regurgitant common atrioventricular valve, pulmonary atresia, patent ductus arteriosus, and inferior vena cava defect with azygos connection was treated successfully with total cavopulmonary shunt and replacement of the common atrioventricular valve. The indications for total cavopulmonary shunt in the management of univentricular heart with azygos continuity are discussed.

Abnormalities, Multiple↗
PubMed1985

Immunohistochemical observation of EGF and NGF in submandibular glands after duct ligation with or without testosterone administration.

Immunohistochemical detection of epidermal growth factor (EGF) and nerve growth factor (NGF) was carried out in duct-ligated submandibular glands (SMG) of mice with or without testosterone treatment. High levels of EGF and NGF were limited to granular convoluted tubule (GCT) cells in normal adult male mice, and reduced levels were evident in the female. After duct ligation, EGF and NGF stainings began to decrease on the 2nd or 3rd day, and by the 10th day, no staining was detectable. Decreasing levels of EGF and NGF following duct ligation, were more pronounced in the male SMG than in the female. Testosterone administration before ligation resulted in decreased EGF and NGF levels of staining; however, staining of sections on the 1st and 3rd day was a little stronger than comparable stained sections of untreated mice. In contrast, testosterone administration after duct ligation showed GCT cells of normal size with some degranulation at 10 days and irregular staining of growth factors with varying degrees of degranulation at 14 days. Histochemical staining for EGF and NGF in this group was marked, as in the normal, until the 10th day with decreasing reactions by the 14th day.

Animals↗
PubMed1985

Lectin histochemistry of submandibular glands following duct-ligation in mice and rats.

Lectin binding patterns of Con A, PNA, SBA, DBA, WGA, RCA-1 and UEA-1 were carried out in duct-ligated submandibular glands (SMGs) of rats that displayed acute degenerating changes. Lectin staining was also related to histologic changes. Proliferating epithelial cells which were probably derived from intercalated duct cells showed a strong SBA and WGA staining on the 3rd day. Duct-like and cystic structures appeared on the 7th day and staining by PNA, SBA, WGA, RCA-1 and Con A was described. In mice, lectin binding after duct ligation appeared similar to the rat. In the long-term observation of mice SMGs, acinar cell regeneration occurred between the 21st and 42nd days and they stained strongly for DBA.

Animals↗
PubMed1985

[Combined chemotherapy for head and neck cancer using cisplatin, methotrexate and continuous subcutaneous infusion of peplomycin].

Twenty-one patients with advanced or recurrent squamous cell carcinoma of the head and neck were treated with cisplatin, methotrexate and continuous subcutaneous infusion of peplomycin. The overall response rate was 62% (13/21) with 19% (4/21) complete response. The median duration of partial response was 2 months, while that of complete response was 3 months. Toxic effects were acceptable with no fatalities, but nephrotoxicity (33%), leukocytopenia (24%), thrombocytopenia (29%) and severe nausea and vomiting (76%) occurred. Pulmonary toxicity due to continuous subcutaneous infusion of peplomycin (15 mg/day, 4 days) was not seen.

Adult↗
PubMed1985

Why is a specific amino acid sequence of F glycoprotein required for the membrane fusion reaction between envelope of HVJ (Sendai virus) and target cell membranes?

Since homology among the fusogenic sequences of the F glycoprotein of paramyxoviruses is high compared with other hydrophobic sequences such as transmembrane sequences and signal peptides, specific binding of this segment to some membrane component was suspected. Thus, temperature-dependent binding of cholesterol to F protein was found. A virus inhibitory peptide (Z-D-Phe-L-Phe-Gly) was found to bind to virus particles also temperature dependently. These dependency are very similar to that of the fusion reaction. Binding of cholesterol and the peptide to the fusogenic sequence of F protein was suggested based on construction of molecular models. Importance of these bindings for understanding the fusion mechanism is discussed.

Amino Acid Sequence↗
PubMed1985

[Coronary sinus type atrial septal defect diagnosed by two-dimensional color Doppler echocardiography: a case report].

This is a case report of coronary sinus type atrial septal defect (ASD) diagnosed preoperatively by two-dimensional color Doppler echocardiography. A 22-year-old asymptomatic woman was admitted for preoperative cardiac evaluation. A cardiac murmur and cardiomegaly had been noted at a routine examination which included electrocardiography and chest radiography, and M-mode echocardiography suggested the presence of a secundum type ASD. Color Doppler echocardiography revealed a left to right atrial shunt flow through the coronary sinus ostium into the right atrium. By peripheral contrast echocardiography, a negative contrast echo from the coronary sinus ostium was observed within the right atrium and persistent left superior vena cava was excluded. At operation, a 2 X 3 cm defect was demonstrated at the interatrial septum in the vicinity of the coronary sinus ostium. This is the first reported case of a coronary sinus type ASD diagnosed preoperatively by color Doppler echocardiography.

Adult↗