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Biomedical subjects

K Andoh

Publications and source records attributed to K Andoh.

At least 91 records · Page 5Linked to original sources

[Anesthesia for a patient with HELLP syndrome].

A case of 30 year-old female with HELLP syndrome, who had undergone emergency caesarean section under general anesthesia, was reported. HELLP syndrome is characterized by hemolysis, liver dysfunction and thrombocytopenia, besides symptoms of severe toxemia of pregnancy. After an awake orotracheal intubation, anesthesia was maintained with nitrous oxide, oxygen and muscle relaxant. Blood pressure was controlled with intravenous administration of nitroglycerin. Though the eclampsia was recognized several times during and after the operation, the patient and her baby had no complication nor sequela on their discharge. The key in the anesthetic management of caesarean section in a patient with HELLP syndrome is to control hypertension and eclampsia, to consider the presence of liver and kidney dysfunctions, and to improve anemia and bleeding tendency.

Adult↗

Interaction of plasma clotting factors with vascular endothelial cells in hemostasis and thrombosis with special reference to endothelial cell tissue factor.

The interaction of plasma clotting factors with vascular endothelial cells was investigated. Human umbilical cord vein endothelial cells generated tissue factor activity after treatment with various stimulators including IL-1. Cycloheximide inhibited production of the tissue factor in the cells, but did not affect the expression of the tissue factor activity on the surface of endothelial cells. Endotoxin-treated vascular endothelial cells activated Factor X in the presence of Factor VII and calcium ion. Activation of Factor X by endothelial cells with Factor VII was enhanced by the presence of both Factors VIII and IX. Binding study revealed that endotoxin-treated endothelial cells bound Factor IX. These data suggest that perturbed vascular endothelium expresses tissue factor activity on the cell surface, binds factor IX and in the presence of Factor VII, activates not only factor X but also Factor IX.

Blood Coagulation Factors↗

Tissue factor activity in leukemia cells. Special reference to disseminated intravascular coagulation.

Tissue factor activity (TFA) of 10(8) leukemia cells was measured in 82 patients with acute nonlymphoid leukemia by the clotting method. The TFA bore a significant correlation to the development of disseminated intravascular coagulation (DIC) in these cases. Mean TFA value with standard deviation (SD) was 8.3 +/- 6.3 U in 48 cases with DIC, which was significantly higher than 0.3 +/- 4.2 U in 34 cases without DIC. Whereas Mean TFA in non-M3 was 0.9 +/- 6.3 U which was significantly lower than 37.2 +/- 2.3 U in M3, some non-M3 showed TFA as high as M3 and were complicated by DIC. In heparin treatment, dosage of heparin could not be controlled by either APTT or AcCT but was controlled by the extent of TFA of leukemia cells. Retrospective analysis of clinical features revealed that 97000X + 9000 units/day (X = logarithm value of TFA) of heparin is an adequate dosage for the successful treatment of DIC when TFA of leukemia cells is 0.8 U or more.

Adolescent↗

[An interview survey on health care service in small-sized manufacturers in a city of Osaka Prefecture].

An interview survey on the health care service for workers employed in small-sized enterprises was conducted in a city of Osaka Prefecture. Items surveyed were: 1) number of full-time and part-time employees by age (less than 39, 40-60, and more than 60 yr) and sex, 2) materials and production process, 3) periodic examinations for general health status and occupational diseases, and others. Of the 526 enterprises interviewed, 459 manufacturers with less than 50 employees were analyzed. The results can be summarized as follows: 1. Of the 459 manufacturers, 72.4% were those with less than 10 workers (the mean number of employees: 8.4). The major type of manufacture was electric parts processing industry. 2. The period health examination has been carried out in 372 enterprises (81.0%). The smaller the size of the company, the lower was the rate of the periodic health examination. 3. In 77.4% of the 372 enterprises, only chest X-ray was an item for the periodic health examination, which was usually carried out at the public health center of the community. 4. The number of enterprises conducting the periodic health examination designated by the Industrial Safety and Health Law (1972) was only 49 (10.7%). 5. Fourteen enterprises (3.1%) have carried out periodic examination for occupational diseases. 6. The periodic examination for degenerative diseases such as hypertension, diabetes mellitus, and other cardiovascular diseases was carried out in 57 enterprises (12.4%). The larger the size of the company, the higher was the rate in which such examination was conducted.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

Radioimmunoassay of human tissue factor.

The apoprotein (AP) of tissue factor (TF) has been purified 72,000-fold to homogeneity from human placenta using acetone delipidation, sodium deoxycholate (DOC) extraction, Sephacryl S-300 column chromatography, preparative polyacrylamide-gel electrophoresis (PAGE) in DOC and tryptic digestion. The purified AP had an apparent molecular weight of 54,000 by sodium dodecyl sulfate/PAGE. A radioimmunoassay (RIA) for quantitation of the TF-AP using an antibody against this purified AP of TF was devised which was sensitive enough to measure as small a quantity as 100 pg/ml of TF-AP accurately with high reproducibility. In addition to TF clotting activity (TFA), the immunoreactive TF-AP (IR-TFR) in the homogenates of leukemic leukocytes from patients with acute non-lymphoid leukemia (ANLL) was determined using this RIA. In 30 patients with ANLL, the mean IR-TFR with standard deviation (SD) of 21 cases with DIC was 157.9 +/- 188.1 ng/10(8) cells, which was significantly higher than that (37.1 +/- 29.9 ng/10(8) cells) of 9 cases with no DIC during remission induction chemotherapy (p less than 0.01).

Apoproteins↗

[Experimental study of hypertrophy of the femoral head--with special reference to the effects of the surgical procedure on the hip joint].

This experimental study was performed to clarify how a surgical procedure to the hip joint causes hypertrophy of the femoral head. Young rabbits were used for this experiment. The following results were obtained. In the rabbits with sectioned ligamentum teres, some cases showed complete dislocation on X-ray. The incidence of the hypertrophy of the femoral head was very low in this group. Except in these rabbits with dislocation, the hypertrophy of the femoral head appeared in any group subjected to surgical procedure, and at especially high rates in those subjected to the section of ligamentum teres and/or edge resection of acetabular cartilage. In the cases in which the edge of the acetabular cartilage was resected, and in other cases of surgical procedure as well, acetabular dysplasia often resulted. In these cases the hypertrophy of the femoral head was observed more frequently than in others. In summary, surgical procedure to the hip joint and postoperative abnormal stress to the femoral head contribute to the development of the hypertrophy of the femoral head especially in the cases in which acetabular factors are not negligible.

Acetabulum↗

Presence of two subcomponents in P9 far-field potential following stimulation of the median nerve.

Close scrutiny of scalp recorded P9 far-field potentials following stimulation of the median nerve often revealed dilobed wave forms. We observed that the P9 became 2 distinct peaks (P9a and P9b) when the arm was flexed 90 degrees forward at the shoulder and that it became a pointed single peak with 90-170 degrees lateral abduction of the arm. A simultaneously recorded stationary negative peak (N9), registered over the stimulated arm with the use of a distant reference, also showed similar changes, a dilobed configuration (N9a and N9b) with forward flexion and a single peak with lateral abduction. The latencies of the scalp recorded P9a and P9b and arm recorded N9a and N9b were close but not exactly the same. Nevertheless, the latencies of the scalp-positive and arm-negative peaks shifted in nearly a parallel fashion by changing the arm positions. These findings suggest that the change of axial orientation of the propagating nerve impulse plays an important role for the rise of P9a and that the change of volume geometry surrounding the nerve contributes to the P9b generation. Also, the scalp recorded P9 and arm recorded N9 are one and the same, and oriented with dipole fields extending from the arm, body and to the scalp.

Action Potentials↗

The posterior inferior cerebellar artery arising from the extracranial segment of the internal carotid artery via the hypoglossal canal without an interposed segment of the basilar artery: a persistent primitive hypoglossal artery variant.

The authors present a rare case of a persistent primitive hypoglossal artery (PHA) variant ending in the posterior inferior cerebellar artery (PICA) without an interposed segment of the basilar artery and describe briefly the possible embryogenesis of this anomaly.

Carotid Artery, Internal↗

Diffuse pulmonary lesions in early phase Takayasu arteritis predominantly involving pulmonary artery.

We report a case of early phase Takayasu arteritis that predominantly involved the pulmonary arteries and had, along with expected radiographic findings, the unusual pattern of diffuse pulmonary parenchymal lesions on CT. We suggest that this finding may be an additional feature in early phase Takayasu arteritis and need not require investigation for an additional diagnosis.

Aorta↗