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Biomedical subjects

Joshua E Lane

Publications and source records attributed to Joshua E Lane.

At least 37 records · Page 2Linked to original sources
PubMed2004

Avulsion and partial matricectomy with the carbon dioxide laser for pincer nail deformity.

BACKGROUND: Pincer nail deformity is a common nail disorder that sometimes necessitates surgical intervention. A multitude of therapeutic modalities has been implemented to treat this condition. OBJECTIVE: To describe the use of the carbon dioxide laser in the successful treatment of pincer nail deformity. METHODS: This is a case report and literature review. RESULTS: A 63-year-old man was evaluated and treated with the carbon dioxide laser for a persistent pincer nail deformity. The patient tolerated the procedure well and had an acceptable surgical outcome. CONCLUSION: Pincer nail deformity may be successfully treated with the carbon dioxide laser, especially when a partial matricectomy is performed.

Humans↗
PubMed2004

Successful carbon dioxide laser therapy for refractory anogenital lichen sclerosus.

BACKGROUND: Lichen sclerosus is a chronic inflammatory dermatitis that often occurs in the anogenital area and presents a therapeutic challenge. Traditional medical management includes potent topical corticosteroids and is marked by variable results. OBJECTIVE: The objective was to describe the successful use of carbon dioxide laser ablation therapy in two women with refractory anogenital lichen sclerosus. METHODS: A case is reported and the literature is reviewed. RESULTS: Two women with medically recalcitrant anogenital lichen sclerosus were successfully treated with the carbon dioxide laser. Both patients tolerated the procedure well and had excellent surgical outcomes. CONCLUSION: Lichen sclerosus recalcitrant to medical therapy presents a therapeutic challenge This may be successfully treated with the carbon dioxide laser with excellent surgical results and minimal risk.

Anus Diseases↗
PubMed2004

Paraneoplastic autoimmune multiorgan syndrome (paraneoplastic pemphigus) in a child: case report and review of the literature.

Paraneoplastic autoimmune multiorgan syndrome, also known as paraneoplastic pemphigus, has been observed only rarely among children. We describe a 10-year-old boy with typical clinical and histologic findings of paraneoplastic pemphigus associated with Castleman's disease. His disease was refractory to resection of the tumor and aggressive combination immunosuppressive therapies. The patient died 1 year after presentation, as a result of complications of bronchiolitis obliterans. This case is unusual because of the young age of the patient.

Bronchiolitis Obliterans↗
PubMed2003

Detection of Trypanosoma cruzi DNA within murine cardiac tissue sections by in situ polymerase chain reaction.

The use of in situ techniques to detect DNA and RNA sequences has proven to be an invaluable technique with paraffin-embedded tissue. Advances in non-radioactive detection systems have further made these procedures shorter and safer. We report the detection of Trypanosoma cruzi, the causative agent of Chagas disease, via indirect and direct in situ polymerace chain reaction within paraffin-embedded murine cardiac tissue sections. The presence of three T. cruzi specific DNA sequences were evaluated: a 122 base pair (bp) sequence localized within the minicircle network, a 188 bp satellite nuclear repetitive sequence and a 177 bp sequence that codes for a flagellar protein. In situ hybridization alone was sensitive enough to detect all three T. cruzi specific DNA sequences.

Animals↗
PubMed2003

Epidermodysplasia verruciformis.

Epidermodysplasia verruciformis is an uncommon cutaneous entity characterized by persistent human papillomavirus infection. A defect in cell-mediated immunity is the suggested causative factor. Numerous specific human papillomavirus types have been detected in this disease. Multiple nonmelanoma skin cancers are commonly seen in such patients; thus, early diagnosis is beneficial.

Epidermodysplasia Verruciformis↗
PubMed2002

Chronic acetaminophen toxicity: a case report and review of the literature.

Acetaminophen is one of the most frequently used medications in the United States. While usual dosing of acetaminophen is considered harmless, both acute and chronic overdoses can be fatal. The majority of reported cases of chronic acetaminophen toxicity in adults occur in chronic alcohol abusers, patients taking P450-inducing medications, or following massive dosing. We describe a case of toxic hepatitis free of the aforementioned risk factors associated with chronic ingestion of moderately excessive doses of acetaminophen. Our patient ingested approximately 5.0 to 6.5 g of acetaminophen daily for 6 to 8 weeks via multiple medications. The inclusion of acetaminophen in numerous medications combined with the frequency of use of acetaminophen necessitates an increased concern for not only acute but also chronic acetaminophen toxicity.

Acetaminophen↗
PubMed2002

Cutaneous sclerosing extramedullary hematopoietic tumor in chronic myelogenous leukemia.

BACKGROUND: Extramedullary hematopoiesis is a well-documented manifestation of chronic myeloproliferative disorders, most commonly seen in chronic idiopathic myelofibrosis (agnogenic myeloid metaplasia), but rarely in chronic myelogenous leukemia. It typically occurs in the spleen and liver, but has also been described in skin. Microscopically, foci of extramedullary hematopoiesis consist of erythroid and myeloid precursors intermixed with megakaryocytes. The megakaryocytes may elaborate fibrogenic cytokines, which induce proliferation of fibroblasts. The term 'sclerosing extramedullary hematopoietic tumor' has been applied to this latter entity and its resemblance to a fibrohistiocytic neoplasm has been noted. METHODS: We report the case of a 66-year-old man, whose cutaneous sclerosing extramedullary hematopoietic tumor preceded the diagnosis of chronic myelogenous leukemia.

Aged↗
PubMed2002

Tibialis anterior muscle herniation.

BACKGROUND: Tibialis anterior herniation occurs through a defect in the deep fascial layer of the lower extremity. While this entity is not uncommon, it has been rarely reported in the dermatologic literature. OBJECTIVE: To highlight the occurrence of tibialis anterior herniation and its presentation and treatment. METHODS: Case report. RESULTS: We present a case of tibialis anterior herniation in a patient who presented with asymptomatic nodules in her lower extremities. The nodules were flesh-colored, soft, and compressible with palpation. CONCLUSION: The diagnosis of tibialis anterior herniation should be considered in patients with positionally variable subcutaneous nodules, especially in the lower extremities. It is caused by a defect in the deep fascial layer and often involves the lower extremities. In addition, knowledge of the diagnosis and treatment is essential for both proper management and/or surgical referral.

Adult↗
PubMed2002

Treatment of pearly penile papules with CO2 laser.

BACKGROUND: Pearly penile papules are angiofibromas found on the corona and sulcus of the glans penis. While these represent a benign condition, psychological and cosmetic concerns often prompt patients to seek therapeutic removal of these lesions. Multiple therapeutic modalities have been reported; however, use of CO2 laser has proven to be the most effective to date. OBJECTIVE: To demonstrate the efficacy of CO2 laser in treating pearly penile papules. METHODS: Case report. RESULTS: We report the successful treatment of pearly penile papules in an African American man with CO2 laser. CONCLUSION: The use of CO2 laser is an effective treatment for pearly penile papules. J. E. Lane, MD, C. M. Peterson, MD, and J. L. Ratz, MD have indicated no significant interest with commercial supporters.

Adult↗
PubMed2002

Beals-Hecht syndrome.

Beals-Hecht syndrome, also known as congenital contractural arachnodactyly, is caused by a defect in fibrillin as in Marfan syndrome. This syndrome is characterized by a multitude of clinical findings including arachnodactyly, narrow body habitus, scoliosis, congenital contractures, and external ear deformities. Restrictive lung disease may be associated with the severe scoliosis and thoracic cage abnormalities in this syndrome. We describe a child with Beals-Hecht syndrome and review the literature.

Child↗
PubMedDate not supplied

Bilobed thumbnails with erythronychia.

Onychodystrophy is a common problem and may have multiple causes, both internal and environmental. We present an unusual nail finding in a gentleman without any identifiable etiology. He and several family members had isolated notching of the thumbnails with a characteristic erythematous band.

Aged↗