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Biomedical subjects

John E Cooper

Publications and source records attributed to John E Cooper.

14 recordsLinked to original sources
PubMed2005

Determining the chronology and components of psychosis onset: The Nottingham Onset Schedule (NOS).

The Nottingham Onset Schedule (NOS) is a short, guided interview and rating schedule to measure onset in psychosis. Onset is defined as the time between the first reported/observed change in mental state/behaviour to the development of psychotic symptoms. Onset is conceptualised as comprising of (i) a prodrome of two parts: a period of 'unease' followed by 'non-diagnostic' symptoms; (ii) appearance of psychotic symptoms; and (iii) a build-up of diagnostic symptoms leading to a definite diagnosis. Twenty consecutive cases of first-episode psychosis were administered the NOS schedule to determine its psychometric properties including inter-rater and test-retest reliability. Its clinical and research potential as a reliable measure of duration of untreated psychosis (DUP) was assessed in a cohort of 99 cases of first-episode psychosis (56 schizophrenia, 43 affective psychoses). NOS identified all prodromal symptoms previously reported in other studies. There was high degree of inter-rater and test-retest reliability for all components of NOS. Duration of untreated psychosis was significantly longer (p<0.05) in schizophrenia (mean 179 days, S.D. 344; median 52 days) than in affective psychosis (mean 15 days, S.D. 116; median 12 days) but there were no gender differences between lengths of prodrome or treatment delays. The NOS provides a standardised and reliable way of recording early changes in psychosis and identifying relatively precise time points for measuring several durations in emerging psychosis. The scale is easy to use and is not time-consuming or labour intensive. Onset, as measured by NOS, is significantly longer in schizophrenic disorders than in affective psychosis. A small proportion of schizophrenia cases have very long DUP. Some cases with schizophrenia receive anti-psychotics in the prodromal phase, prior to the emergence of frank psychotic symptoms.

Adult↗
PubMed2004

Invertebrate care.

Invertebrates are attracting increasing interest within the veterinary profession. They are also significant in their own right; as the Council of Europe's "Charter on Invertebrates" points out, they are the most important component of wild fauna as well as providing food, contributing to agriculture and forestry, and aiding medicine,industry, and crafts. Whenever invertebrates are kept in captivity they should be subject to high standards of management and care and veterinary attention-whether by the veterinarian or by the veterinary technician-should be based on sound biological and humanitarian principles.

Animal Husbandry↗
PubMed2004

Oncology of invertebrates.

In this article, "Invertebrates" are considered to be all those animals that are not in the five main groups of vertebrates (Mammalia,Aves, Reptilia, Amphibia, and three classes of fish), and the term neoplasm is used in its traditional sense of "new, uncontrolled, growth". The history of study of such lesions is reviewed and methods of investigation and control are outlined.

Animals↗
PubMed2003

Use of cidofovir in polyomavirus BK viral nephropathy in two renal allograft recipients.

Polyomavirus BK viral allograft nephropathy is a potentially reversible cause of deteriorating function of kidney allografts. Initial treatment involves reducing immunosuppressive medications, with low-dose cidofovir an effective alternative in refractory cases. We describe two cases of BK viral allograft nephropathy responding to low-dose cidofovir after a reduction in immunosuppressive medications failed to clear the virus or stabilize the deterioration in renal function. There were no significant side-effects from this treatment in either patient.

Antiviral Agents↗
PubMed2002

Comparison of hematologic and biochemical reference ranges between captive populations of northern bald ibises (Geronticus eremita).

Hematologic and biochemical reference ranges for two captive populations of northern bald ibises (Geronticus eremita) were compared. The first consisted of 11 birds at an in-situ breeding colony in Bireçik, southern Turkey. The second consisted of 27 birds housed at the Durrell Wildlife Conservation Trust in Jersey, British Channel Isles (UK). Blood samples were collected in February 1992 by basilic venipuncture under manual restraint. Bireçik birds had higher packed cell volumes and red blood counts but lower white blood cell and lymphocyte counts than Jersey birds. Bireçik birds also had higher total protein, albumin, total globulin, calcium, phosphorus, blood urea nitrogen, and total bilirubin values; higher albumin to globulin ratios; but lower uric acid values and calcium to phosphorus ratios than Jersey birds. Finally, Bireçik birds had higher lactate dehydrogenase but lower gamma glutamyl transferase values than Jersey birds. Male Jersey birds had higher calcium and alkaline phosphatase values, but lower white blood cell and heterophil counts than female Jersey birds. The apparent differences between the two populations are not thought to be biologically significant and may be related to diet and state of hydration.

Animals↗