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Biomedical subjects

Jagdish Butany

Publications and source records attributed to Jagdish Butany.

At least 73 records · Page 4Linked to original sources
PubMed2002

Prosthetic heart valves with silver-coated sewing cuff fabric: early morphological features in two patients.

BACKGROUND: The current generation of prosthetic heart valves are excellent examples of engineering that work well, for long periods of time. Unfortunately, host-related problems and consequent valve failure continue to occur, including infective endocarditis. St Jude Medical Inc introduced a new model of mechanical heart valve prosthesis with silver-treated fabric to try to reduce the incidence of infective endocarditis. Two cases of failure of this prosthesis, with a clinical diagnosis of infective endocarditis, are presented. MATERIALS AND METHODS: Of the 176 St Jude Medical Silzone-coated prostheses implanted, two were explanted in the first half of 1998. The clinical status of the patients was reviewed, and a detailed gross, histological and stereomicroscopic examination of the prosthetic valves was undertaken. RESULTS: Clinically, both patients developed symptoms of infective endocarditis. The first patient developed features of a stroke and two months later underwent a second valve replacement. The prosthesis showed pannus and thrombus. A paravalvular leak was revealed in the second patient, who underwent a second valve replacement six months after the initial surgery. Blood and tissue cultures were negative in both cases. CONCLUSIONS: The new model St Jude Medical Silzone mechanical heart valve prosthesis, designed to prevent infective endocarditis, was associated with clinical features of endocarditis in these two cases. Significant pannus and thrombus were seen on both prostheses, which likely led to emboli and stroke in the first case. The cause of the paravalvular abscess in the second case has not yet been established. The early failure of these prostheses suggests that patients with this prosthesis be followed up carefully.

Endocarditis, Bacterial↗
PubMedDate not supplied

DeBakey Surgitool mechanical heart valve prosthesis, explanted at 32 years.

Contemporary mechanical heart value prostheses are expected to last "just about forever" or the patient's lifeline. They do however still suffer complications, some of which necessitate premature explantation. Complications today are mainly related to patient compliance with anticoagulant medication, infection and hemorrhage. The DeBakey Surgitool mechanical heart valve was the first such device to have Pyrolyte components. We present a DeBakey surgitool mechanical heart valve that was in place for 32 years! It was explanted for dysfunction related to tissue overgrowth and not to its related components. With good patient compliance, this mechanical heart valve prosthesis is an example of good prosthetic valve durability.

Aortic Valve↗
PubMedDate not supplied

Morphological findings in explanted Toronto stentless porcine valves.

BACKGROUND: Stentless porcine valves have many documented advantages over stented valves. Since its introduction in 1991, the Toronto stentless porcine valve (T-SPV) has shown excellent hemodynamic performance. METHODS: A total of 332 T-SPVs have been implanted at our institution up to December 2003, 25 of which have been explanted at surgery. Herein, we report a study of 30 explanted T-SPVs seen at our institution over a 5-year period. RESULTS: The mean patient age at explant was 61.2+/-11.8 years with a mean implant duration of 100.7+/-27.8 months (after excluding one valve removed early postoperatively for infective endocarditis). Twenty-seven of 30 valves (90%) showed structural deterioration characterized by tissue degeneration, cusp tears, calcification, and lipid insudation. Eight valves (26.7%) showed evidence of calcification on gross inspection and a total of 23 valves (76.7%) showed at least one microscopic focus of calcification, located primarily in the basal and commissural regions of the cusp. Twenty valves (66.6%) showed cusp tears. Pannus was visible grossly on the surface of 27 of 30 valves (90%), while histologically, at least some degree of pannus was observed on both the inflow and outflow surfaces of all but two valves. Twelve T-SPV (40.0%) showed calcification in the porcine aortic tissue, four of which involved calcification of the porcine muscle shelf in the right coronary cusp. Two T-SPV showed no significant structural deterioration. Their clinical reason for explantation was incompetence or infective endocarditis. CONCLUSION: With a freedom from reoperation of about 87.0% at up to 10 years, the T-SPV shows excellent durability. The majority of explanted valves show structural valve deterioration similar to that seen in other porcine heart valves.

Animals↗
PubMedDate not supplied

Leiomyosarcoma of the inferior vena cava.

Leiomyosarcoma of the inferior vena cava is a rare neoplasm; however, it is the most frequent tumor of vascular origin. It is classified according to site of origin that reflects its clinical presentation and prognosis. They are generally recognized to be of smooth muscle cell origin. Surgical resection is the treatment of choice. The role of adjuvant therapy for leiomyosarcoma is not established.

Aged↗
PubMedDate not supplied

A giant coronary artery aneurysm in the right coronary artery.

Aneurysms of the coronary arteries are uncommon occurrences that usually develop secondary to atherosclerosis and are often asymptomatic. They are usually diagnosed incidentally during investigation for ischemic heart disease or at autopsy for sudden death. We present a case of a "giant" right coronary artery aneurysm (CAA) discovered incidentally at surgery. Pathological examination confirmed that this was a true aneurysm showing marked thinning of the media and fibrocalcific plaques with small, multifocal areas of lymphocytic infiltrates.

Atherosclerosis↗
PubMedDate not supplied

The intricacies of cardiac sarcoidosis: a case report involving the coronary arteries and a review of the literature.

BACKGROUND: Primary cardiac sarcoidosis (CS) is rare, and concomitant involvement of the coronary arteries is rarer still. Successful diagnosis of this disease is difficult due to its nonspecific symptoms which mimic those of idiopathic dilated cardiomyopathy (IDCM). METHODS AND RESULTS: We describe a 47-year-old Caucasian male who underwent orthotopic heart transplant for presumed IDCM. Examination of the explanted heart revealed numerous nonnecrotizing granulomata throughout, similar granulomata in the walls of the large coronary arteries, and large areas of fibrosis. CONCLUSIONS: In cases of IDCM with symptoms of angina or acute coronary syndrome, the possibility of CS should be considered. Herein, we present this case and a review of the relevant literature.

Angina Pectoris↗
PubMedDate not supplied

Pathology of infectious and inflammatory diseases in prosthetic heart valves.

Prosthetic heart valves, both mechanical and biological (xenograft valves, stented or unstented), show an inflammatory reaction (infective endocarditis), associated predominantly with bacterial/fungal infection. Somewhat surprisingly, no immune-mediated reaction has been reported thus far. This may, among other reasons, be related to the fact that the tissues are "fixed" with aldehydes and are virtually isolated from host circulation, separated by synthetic material (the valve stent and the fabric covering it). Stentless valves (especially these without fabric covering them), however, have no such "isolation" from the host circulation. While the Toronto-Stentless Porcine Valve has a covering of fabric, the Medtronic Freestyle valve has no such covering. It is perhaps not so surprising therefore that at the intermediate time point of 5 to 6 years, some valves are beginning to show such an immune reaction.

Heart Diseases↗
PubMedDate not supplied

A 10-year comparison of explanted Hancock-II and Carpentier-Edwards supraannular bioprostheses.

BACKGROUND: Bioprosthetic heart valves are more frequently being used in valve replacement procedures today. Although second-generation bioprosthetic valves have improved functionality over their first-generation counterparts, they still often fail due to primary tissue degeneration. METHODS: This study examines two second-generation porcine valves after surgical explantation, the Hancock-II (HAN; Medtronic Heart Valve Division, Irvine, CA, USA) and the Carpentier-Edwards supraannular (CE-SAV; Baxter Healthcare Corporation, now Edwards LifeSciences, Irvine, CA, USA), with special attention to morphological/histological changes and reasons for valve failure. A total of 98 HAN and 65 CE-SAV valves were explanted and seen over a 10-year period. RESULTS: CE-SAV valves had a longer average implant duration than HAN valves (13.9+/-3.9 years vs. 10.0+/-5.1 years). Compared with HAN valves, CE-SAV valves also had a higher incidence of stent deformation (41.5% vs. 14.3%), calcification (75.4% vs. 54.1%), and pannus (100% vs. 91.8%). CONCLUSIONS: The greater degenerative changes seen with CE-SAV valves over HAN valves may be due to the longer implant duration of CE-SAV valves in this series. To our knowledge, the present study is the first direct morphological comparison of these two valve models.

Adult↗
PubMedDate not supplied

Human-grade purified collagenase for the treatment of experimental arterial chronic total occlusion.

PURPOSE: Chronic total occlusions (CTO) remain a major limitation of percutaneous interventions. Procedural failure is usually due to the inability to cross the lesion with a guide wire. We have previously shown that local administration of a laboratory-grade collagenase followed by a 72-h waiting period may facilitate guide-wire crossing. The aim of the present study was to evaluate the efficacy and toxicity of a human-grade purified collagenase, suitable for clinical use, in facilitating guide-wire crossing in a rabbit model of femoral artery CTO. METHODS AND RESULTS: A chronic total arterial occlusion was constructed in femoral arteries of New Zealand white rabbits. The local administration of purified collagenase solution (150 microg) via an over-the-wire balloon system was performed in 10 CTO. Guide-wire crossing was attempted after 24 h and was successful in all cases. Different doses (50-500 microg) were administered to an additional 17 rabbits to assess collagenase effects. Local subcutaneous bruising was observed at higher doses. Histological evaluation showed no damage to the arterial wall structure. Arterial extracts from collagenase-treated arteries showed increased MMP-2 and MMP-9 activities and higher levels of local MMP-1 and degraded collagen. CONCLUSIONS: Local administration of a human-grade purified collagenase degrades collagen in CTO and is highly effective for the facilitation of guide-wire crossing in CTO.

Angioplasty, Balloon↗