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Biomedical subjects

J Zeitlhofer

Publications and source records attributed to J Zeitlhofer.

At least 109 records · Page 6Linked to original sources
PubMed1982

[Differential diagnostic problems and polygraphic studies in a case of Pickwickian syndrome].

The case report of a male patient with the Pickwickian syndrome is presented. The results of the relevant neurophysiological examinations (polygraphic registration of EEG, electrocardiogram, respiration, thorax excursions, submental and intercostal electromyogram, electrooculogram) give an insight into the pathomechanisms and enable the differential diagnosis to be made between this condition and narcolepsy and also the Kleine-Levin syndrome; respiratory investigations (spirometry, hypercapnic ventilatory response: mouth occlusion pressure) make it possible to differentiate between the Pickwickian and Ondine's curse syndrome. The therapeutic management is discussed.

Adult↗
PubMed1982

Influence of x-ray treatment on antigen-induced experimental arthritis.

Six groups of 3 rabbits each were immunised with ovalbumin and received one intra-articular injection of antigen. The animals of 3 groups received local x-ray irradiation of 600 rads for 8 minutes to the right knee joint 12 days after the intra-articular challenge. Animals of the other 3 groups were not irradiated. The antigen-induced arthritis was investigated by determining the exudation is synovial fluid and by histological study of the synovium examined 48 hours, 7 days, and 4 weeks after the irradiation date. All animals in the nonirradiated groups showed a distinct chronic synovitis. Irradiated animals showed almost no synovitis 48 hours and 7 days following irradiation. In 2 rabbits synovitis had reappeared 4 weeks after irradiation with findings similar to those in the control groups. Only one animal still showed an inhibition of synovitis. X-ray irradiation of non-challenged knees did not induce any pathological changes. This time-limited effect of one local irradiation on antigen-induced arthritis seems to be mainly an anti-inflammatory action. Local immunological inhibition might possibly operate too. X-ray induced inhibition of synovitis is compared with the effect of locally injected radiocolloids.

Animals↗
PubMed1980

Experimental arthritis induced by granulocyte collagenase.

Purified human granulocyte collagenase (1 mg %, 10 mg % or 50 mg %) was injected into rabbit knee joints (three groups of 6 animals each) three times within one week. Synovium and synovial fluid were investigated 18 hours, 1 week and 3 weeks after the last injection. After 18 hours, synovial fluids showed distinct cellular exudation, its size depending on the amount of collagenase applied. A smaller number of cells was seen after one week, while normal cell counts were observed 3 weeks after the last injection. Histologically, synovium showed an acute arthritis after 18 hours, whereas after 1 and 3 weeks a chronic proliferative form of arthritis with predominant activation of fibroblasts was diagnosed. As compared with an experimental arthritis induced with rheumatoid synovial collagenase, granulocyte collagenase was less arthritogenic. Neither trypsin nor saline injections induced distinct cellular exudation into synovial fluids nor histologic signs of arthritis.

Animals↗