The current histologic classification of tumors of the ovary and testis is reviewed, and their relative frequency is illustrated by notifications to the Swedish Cancer Registry from 1959 to 1965. By far the most common neoplasms were epithelial tumors of the ovary (i.e., cystomas). These do not occur in the testis. Cystomas are believed to originate from the surface epithelium (coelomic epithelium, mesothelium) of the ovary, but there is no generally accepted explanation of how the epithelial cells enter the ovary. Based on the absence of cystomas in the testis, the suggestion is advanced that epithelial inclusions may arise during the reparative period following ovulation. The implications of this concept for the histogenesis of cystomas are discussed.

Cystadenoma↗

PubMedDate not supplied

Aspiration biopsy of metastatic carcinoma in lymph nodes of the neck. A review of 1101 consecutive cases.

Explore the source record for details and available documents.

Adenocarcinoma↗

PubMedDate not supplied

Aspiration biopsy of salivary gland tumors. VI. Morphologic studies on smears and histologic sections from mucoepidermoid carcinoma.

The cytologic findings in fine-needle aspiration biopsy of 24 primary mucoepidermoid carcinomas of salivary glands are reviewed. The morphologic details which permit recognition of this tumor in smears of the aspirate are described.

Adult↗

PubMedDate not supplied

3H-thymidine incorporation into mammary carcinoma cells obtained by needle aspiration before and during endocrine therapy.

3H-thymidine autoradiography was used to evaluate DNA-synthesis in carcinoma cells obtained by fine-needle aspiration biopsy from mammary carcinomas. Needle aspirates were analyzed before and after oophorectomy, and before and during treatment with oestrogen or anti-oestrogen (tamoxifen). Tumor regression occurred in 18 patients-in one of four following oophorectomy, in 15 of 38 treated with tamoxifen and in two of three given oestrogen. Seven tumors remained stationary for long periods-up to a year. In 20 cases there was tumor progression. Regression of tumors was preceded by a decrease in the fraction of 3H-thymidine-labeled cells (s-phase cells). The tumors that remained stationary or progressed retained significant levels of 3H-thymidine incorporation. This study thus showed that 3H-thymidine autoradiography can give an early estimate of tumour response to endocrine therapy. Considerable differences were found between the carcinomas in regard to proportions of S-phase cells. Further insight into this parameter may be useful for planning chemotherapy with S-phase specific agents.

Adult↗

PubMedDate not supplied

The prognostic value of the aspiration biopsy smear in mammary carcinoma.

The prognostic significance of various morphologic factors (size of nuclei, nucleoli, mitotic frequency, naked carcinoma nuclei, nuclear:cytoplasmic ratio, size of cell clusters, necrotic matter, mucoid matter, and lymphocytes) was studied in aspiration biopsy smears from 494 carcinomas of the breast. A multivariate analysis of clinical and cytologic variables was performed with regard to five-and ten-year survival.

Biopsy, Needle↗

PubMedDate not supplied

Evaluation of needle aspirates and tissue sections as prognostic factors in mammary carcinoma.

The prognostic influence in operable mammary carcinoma of morphologic predictors evaluated in smears of needle-biopsy aspirate and in tissue sections and of clinical stage was investigated. Size of nuclei in smears of aspirate was found to convey prognostic information of the same order of importance as the variables tubule information and mitotic frequency in tissue sections. The combination of clinical stage with variables in smears and in sections enhanced the explanatory value.

Adenocarcinoma, Mucinous↗

PubMedDate not supplied

Cytologic presentation of mammary carcinoma on aspiration biopsy smears.

Needle aspirates from 598 histologically verified carcinomas of the female breast were reviewed. Four cytologic types were recognized: duct cell, acinic cell, apocrine cell, and mucous cell carcinoma. Duct cell carcinomas were further subdivided into ductal, ductular-acinar, monolayered and dissociated types. The highest ten-year survival rate was found in mucous cell carcinoma, and the lowest ten-year rates in acinic and dissociated duct cell types. The derivation of the mammary carcinomas is discussed on the basis of comparisons with cellular aspirates from benign mammary lesions. It is suggested that ductular-acinar, monolayered, dissociated and acinic cell carcinomas, which comprised about 50 per cent of the tumors originate in the lobular structures of the mammary gland. The problems involved in distinguishing well differentiated forms of the mammary carcinomas from the corresponding benign structures in needle aspirates are also discussed.

Adenocarcinoma, Mucinous↗