50 patients with primary breast cancer were studied to determine the CEA and HCG contents in their tumor cells before any treatment was initiated. Tumor cells were obtained by needle biopsy and each tumor cell population was stained by immunofluorescence. In 21 of the 50 patients, CEA containing cells were found in a frequency ranging from 5 to 80% of the tumor cell population. The results were confirmed by radioimmunoassay of tumor extracts. No apparent relation was seen to cytologic type or grade of differentiation. HCG was detected by IF in 4 tumors with an apocrine cytologic cell type. The level of CEA in plasma was determined before treatment and followed for 2-6 months in 72 patients. CEA was the only measured serum parameter that correlated initially with size and extent of the localized tumor. It was too low to be of use for monitoring primary disease, but should be of value in early detection of metastasis. Posttreatment a low or decreased plasma CEA was seen more often in patients who had had curative treatment than in those given palliative radiation. No raised serum HCG levels were found. Raised serum liver enzymes did not predict the extent of the primary tumor but may be an indication of distant spread. Tumor CEA content and CEA plasma concentration were correlated, although not very strongly. This means that CEA, although present in the tumor, is not always released in measurable amounts.

Alkaline Phosphatase↗

PubMed1978

Stereotactic biopsies and computer tomography in gliomas.

This study was carried out in order to obtain data on the relation between tumour structures seen in computer tomograms and the corresponding histopathology and cytology. Nine consecutive patients were studied, and stereotactic biopsies were obtained from sites determined on contrast enhanced computer tomograms. Biopsies were obtained from tumour areas with high and low contrast uptake and from the low attenuating areas surrounding the tumours. The results indicated a close correlation between the microscopical morphology of gliomas and the pattern of the computer tomogram. Biopsy samples from low-uptake central areas contained tumour tissues, necrotic tissue, and in one case a cyst. Biopsies from high-uptake areas typically contained tumour tissue, whereas biopsies from low-uptake surrounding areas contained oedematous non-tumour tissue. For tumour diagnosis biopsies should be obtained from both low and high attenuating tumour areas.

Aged↗

PubMed1978

Aspiration biopsy of intrapelvic metastases of cervical carcinoma.

The findings at aspiration biopsy of palpable intrapelvic lesions were reviewed in 316 patients who had previously received radiation therapy for carcinoma of the uterine cervix. A cytologic diagnosis of malignant spread had been made in 55 cases. The crude five-year survival rate in these patients was 4 per cent, as compared with 51 per cent among the patients who received a negative cytologic report. Aspiration biopsy was positive in only about 48 per cent of the patients in whom follow-up observations suggested intrapelvic spread of carcinoma. The factors that may have influenced the diagnostic accuracy are discussed. Use of a screw (0.5 mm thick) technique instead of the 22-gauge needle may enhance the diagnostic accuracy.

Biopsy, Needle↗

PubMed1978

Prevention of ovarian cystomas by inhibition of ovulation: a new concept.

Explore the source record for details and available documents.

Contraceptives, Oral↗

PubMed1977

Aspiration biopsy cytology.

After the presentation of the technique of the aspiration biopsy and the mode of preparation and staining of the smears, the author discusses the usefulness and limitations of this procedure in the diagnosis of benign and malignant lymph node lesions. Studies on blastocytic transformation in short-term tissue cultures in the presence of phytohaemagglutinin have indicated that the cells are unimpaired by the needling and/or the negative pressure used in the aspiration. Since the patient experiences little discomfort from fine needle biopsy, the aspiration biopsy of lymph nodes can also be used for sampling cell material in clinical research. The problem of dissemination of tumor cells via the needle track or efferent lymph or blood vessels is also discussed. The use of fine needle aspiration biopsy in diagnosis of malignant tumors does not appear to involve a risk of tumor spread.

Biopsy, Needle↗

PubMed1976

Implantation metastasis after percutaneous transthoracic needle aspiration biopsy.

The risk of tumour spread at aspiration biopsy of pulmonary tumours through the needle track has been analyzed by reviewing the case histories of 1 264 patients with a malignant tumour demonstrated by needle biopsy. Only in one case did metastatic tumour growth develop at the site of the biopsy. The history of this case is presented and the available literature on the subject discussed.

Aged↗

PubMed1974