Search PubMed⌕ Search

Biomedical subjects

J Yamauchi

Publications and source records attributed to J Yamauchi.

At least 91 records · Page 5Linked to original sources
PubMed1986

Identification of inflammatory cells infiltrating renal allografts.

Eight nephrectomies and 13 biopsies of renal allografts (living 15, cadaveric 6) were investigated on the origin of inflammatory cells in the graft tissues by the use of an immunohistologic method (ABC method). Various monoclonal antibodies and heterosera were used to identify different leukocyte subsets. In all specimens the most predominant inflammatory cells were T cells. Other cells decreased in the following order; B cells, neutrophils and monocytes, and natural killer cells. In T cell subsets Leu 2a-positive cells (suppressor/cytotoxic T cells) predominated over Leu 3a-positive cells (helper/inducer T cells) in 4 nephrectomies (living 1, cadaveric 3) and 12 biopsies (living 11, cadaveric 1). Among these 16 cases, 7 were undergoing acute rejection in various degrees, and 9 were without clinical rejection. In the former 7 cases only one was suffering from another disease. In contrast, Leu 3a-positive cells predominated over Leu 2a-positive cells in 1 biopsy (living) and 4 nephrectomies (living 2, cadaveric 2). Four of these 5 cases concurrently had other diseases in addition to acute rejection. Two cases underwent acute tubular necrosis (cadaveric graft nephrectomies) and 2 underwent chronic rejection and crescentic glomerulonephritis (living graft nephrectomies). The one remaining case was without clinical rejection.

Antibodies, Monoclonal↗
PubMed1984

Renal allografts with glomerulonephritic change and proteinuria.

Eight cases of renal allografts with glomerulonephritic change and proteinuria were classified into three groups according to the morphological features of the glomerular lesions. Group I (3 cases): By light microscope, remarkable reduplication of glomerular basement membrane (GBM), widening of mesangial region, and slight increase in mesangial cells, were observed. Electron microscopy revealed thickening of subendothelial space by deposition of electron-lucent material, mesangial interposition, and dense deposits in various regions (mainly in the subendothelial space). Group II (3 cases): By light microscope, crescent formation and reduplication of GBM were observed, while by electron microscope, changes of GBM similar to group I, but less remarkable, were seen. Group III (2 cases): Light microscope revealed spike formation in one case, but not in the other. With an electron microscope, subepithelial dense deposits were observed in both cases. Thickening of subendothelial space by deposition of electron-lucent material was noted in one case, while thickening of lamina densa was observed in the other case. Morphological change caused by rejection was observed in all eight cases, with six cases showing massive proteinuria and the other two showing slight proteinuria.

Adult↗
PubMed1981

Thyrotropin releasing hormone (TRH): its changes in discrete hypothalamic areas after treatment with triiodothyronine, thyroidectomy and acute cold exposure.

In order to elucidate the specific thyrotropic area in the hypothalamus, thyrotropin releasing hormone (TRH) content and concentration were measured in discrete hypothalamic nuclei and areas after triiodothyronine (T3) administration (T3 10 micrograms/rat/day for 6 days), thyroidectomy (TX) and acute cold exposure in male rats. In th TX and T3 groups, serum TSH levels were significantly increased in TX group and markedly decreased in T3 and TX with T3 groups as compared to the sham operated control group (Sham). TX produced a slight but nonsignificant decrease in TRH content in most of the hypothalamic nuclei examined as compared with the Sham group. However, a significant increase in TRH contents was seen in the anterior hypothalamic nucleus (AHN), median eminence (ME) and posterior pituitary (PP) in TX with T3 group as compared to the rats with only TX. In the acute cold stress experiments, serum TSH levels were elevated from 15 to 30 min of 4 degrees C exposure. Together with these peripheral changes, TRH content and concentration in the suprachiasmatic nucleus (SC) were increased significantly at 15 min and had returned to the normal level by 30 min after 4 degrees C cold exposure. However, in the paraventricular nucleus (PV) and dorsal premammillary nucleus (PMD), marked decrease in TRH concentrations were observed with this stress. Therefore, 1) decreased TSH release in TX rats treated with T3 was induced by the block of TRH release from the AHN and ME as compared with the TX group, and 2) elevated serum TSH levels in 4 degrees C cold stress might be induced by the release of TRH from the PMD and PV. These experiments demonstrate that the specific hypothalamic area for TSH release was located in some of the anterior and posterior hypothalamic nuclei and in the ME.

Animals↗
PubMed1981

Immunosuppressive effect of bredinin in the management of patients with renal transplantation.

Clinical effects of bredinin were evaluated in 18 renal transplant patients. Of 12 cases in which administration of azathioprine was suspended due to liver dysfunction and leucopenia, treatment with bredinin resulted in amelioration of these symptoms without harm to the transplanted kidneys in 10 cases. In six other cases, bredinin was used from the time of renal transplantation, and the postoperative course in four of these cases was uneventful, enabling these patients to return to society. The remaining two patients have had to undergo haemodialysis again as their transplanted kidneys failed to function and they showed severe stomatitis in the early postoperative period. The results of clinical use of bredinin in renal transplant patients suggest that this drug is an effective immunosuppressive agent which is without the drawbacks seen with azathioprine. Nonetheless, one must bear in mind that the function of the transplanted kidney should be evaluated carefully before using this drug.

Adolescent↗
PubMed1980

[The effect of gamma-oryzanol on rat pituitary hormone secretion (author's transl)].

gamma-oryzanol (gamma-OZ), a ferulic acid ester of triterpene alcohol, was investigated with regard to its effect on pituitary LH, GH, prolactin and TSH secretion in normal male (M) and ovariectomized female (OVX) rats. gamma-OZ showed a suppressive tendency of LH by a single intravenous injection and also markedly reduced the LH release induced by LHRH when compared with only vehicle-dosed control groups in M and OVX rats. Serum prolactin release induced by TRH was markedly suppressed by 6 days pretreatment with gamma-OZ in OVX rats. These data suggest that gamma-OZ is a potent inhibitor of LH release and may be a weak inhibitor of prolactin in rats.

Animals↗
PubMed1980

Stimulatory effects of gamma-aminohydroxybutyric acid (GABOB) on growth hormone, prolactin and cortisol release in man.

Healthy male volunteers injected subcutaneously with 200 mg L-GABOB showed no significant changes in plasma GH, prolactin and cortisol levels. On the other hand, an intrathecal injection of 300 mg D, L-GABOB to cerebrovascular patients caused significant increases in plasma GH, prolactin and cortisol levels at 60 min after injection. These results indicate that GABOB may elicit the secretion of GH, prolactin and ACTH via the central nervous system.

Adrenocorticotropic Hormone↗