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Biomedical subjects

J Wysocki

Publications and source records attributed to J Wysocki.

At least 55 records · Page 3Linked to original sources
PubMed1997

Hepatitis B and C virus infection in Polish children with malignancies.

UNLABELLED: Infections by hepatotropic viruses belong to the most common complications of chemotherapy in children suffering from neoplastic diseases. The rate of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and the effectiveness of passive immunization against HBV were studied in 285 children; 148/285 with lymphoproliferative diseases and 137/285 with solid tumours. HBV infection was observed in 10.2% children receiving hepatitis B immune globulin as compared to 36.8% without passive immunization against HBV. Anti-HCV antibodies were similar in both groups amounting 38.7% and 32.6% respectively. CONCLUSION: The results show that hepatitis B immune globulin administration is effective and that HCV might become the main cause of hepatitis among immunosuppressed patients in the future.

Adolescent↗
PubMed1996

Vascularization of the sartorius muscle.

The sartorius muscle is used for the reconstructive procedures. The study of its blood supply have been undertaken owing to many data of successful transplantation of this muscle. We examined 60 muscles from cadavers of both sexes of age from 17 to 69 years. The muscle receives 5 to 11 vessels originating from: superficial circumflex iliac, lateral femoral, deep femoral, descending geniculate, and femoral arteries. The vessels extend irregularly along the muscle. Neighboring arteries form only sparse anastomoses, diameter of which does not exceed 0.25 mm. The pattern of blood supply to the sartorius muscle is usually segmental.

Adolescent↗
PubMed1995

[Interferon alpha in the treatment of chronic hepatitis B in children].

Nine children suffering from chronic hepatitis due to hepatitis B virus (HBV) infection were treated with recombinant IFN-alpha-2C for 16 weeks. Replication of HBV was inhibited in 5 cases while a decreased inflammatory process in the liver was attained in 3. The treatment was very well tolerated in all of the studied children. A significant increase of ALT activity in the fourth week of treatment seems to be a positive prognostic factor.

Adolescent↗
PubMed1995

[Head and neck tuberculosis: a still urgent problem].

The upper respiratory tract is an unusual site for tuberculous infection. Most of the cases are secondary to active pulmonary tuberculosis. We present thirty five cases of tuberculosis localize in the head and neck region. There were twelve patients with lymphonodular tuberculosis, eleven patients with laryngeal tuberculosis, six patients with oral and pharyngeal tuberculosis, three patients with partoid gland tuberculosis, two patients with nose and paranasal sinuses tuberculosis and one patient with middle ear tuberculosis. This cases exemplifies the difficulty in diagnosis of tuberculosis in such an unusual sites.

Adolescent↗
PubMed1995

Mastoid emissary in man. An anatomical-clinical study.

The purpose of the study was establishing differences in the situation of the external orifice of the emissary, its size and angle at which it leaves the skull. It is necessary for optimizaing of position for the internal coil of the speech processor of cochlear implant. As yet, the variability of external foramen of this emissary have not been sufficiently studied, especially in the clinical aspect with respect to the use of cochlear implants. The authors examined 200 skulls of adults of both sexes. The statistically significant differences were observed between sexes and between sides of the body, and they showed a definite regularity. The variability of the site of the emissary is presented in a form useful for clinical purposes.

Adult↗
PubMed1995

[Advanced nasopharyngeal tumor].

Nasopharyngeal cancer is a rare neoplasm in most parts of the world, it is the most common cancer the Chinese. Nasopharyngeal cancer is often misdiagnosed because of the variety of subtle signs and symptoms and the difficulty of examining this region. The most common neoplasms of the nasopharynx are epithelial malignancies originates from epithelial cells in the nasopharynx. The authors has presented a rare case of advanced nasopharyngeal adenocarcinoma.

Adenocarcinoma↗
PubMed1995

[A case of maxillary tumor--difficulties with diagnosis and treatment].

Atypical fibroxanthoma is an uncommon mesenchymal neoplasm. It is cytologically malignant but usually clinically being tumor which typically arises in sundamaged skin of the head and neck region. The principal differential diagnoses are spindle cell squamous carcinoma, melanoma and leiomyosarcoma. Immunohistochemistry plays a key role in diagnosis. We report a patient with atypical fibroxanthoma of the maxilla and the neck.

Adult↗
PubMed1994

[Metastasis of clear cell renal cancer to the nose and nasal sinuses].

Metastases of malignant tumours of remote location to the nose and nasal sinuses are rare. The possibility of their occurrence should be, however, taken into account, since rhinological manifestations may precede the diagnosis of primary tumour. This is true especially in the case of clear-cell renal cancer whose metastases are the most frequently found secondary malignant tumours of the nose and nasal sinuses. A case is described of clear-cell renal cancer metastasis to the frontal sinus.

Adenocarcinoma, Clear Cell↗
PubMed1993

Impairment of the oxygen-dependent microbicidal mechanisms of polymorphonuclear neutrophils in patients with type 2 diabetes is not associated with increased susceptibility to infection.

Phagocytosis, bactericidal capacity and some selected parameters of oxygen-dependent bactericidal mechanisms were evaluated in 20 patients with type 2 diabetes being in similar (intermediate) state of metabolic control and in 15 healthy individuals. Polymorphonuclear neutrophils (PMNs) from diabetics showed normal ability to phagocytose staphylococci, a decreased Intracellular bacteria killing, the impaired stimulated superoxide anion (O2-) and hydrogen peroxide (H2O2) production and the low intracellular myeloperoxidase activity. The obtained data seem to indicate that the decreased bacterial killing by PMNs isolated from diabetics are partly at least related to an impairment of the oxygen-dependent bactericidal mechanisms. Since none of the diabetic patients suffered from recurrent infection the clinical significance of our finding is still uncertain.

Adult↗
PubMed1993

Adherence of blood T cells to rat microvascular endothelial cells. Comparative studies of T lymphocytes isolated from various tissues.

Lymphocytes isolated from various tissues exhibit different magnitudes of adherence to endothelial cells (EC) in vitro. Nevertheless, a good correlation between the lymphocyte adherence to EC in vitro and their migratory properties to sites of inflammation in vivo was found. The main goal of this study was to compare, using unstimulated and IFN-gamma-, TNF-alpha- or LPS-pretreated EC, the adherence of T cells isolated from blood (BTC), with the adherence of T lymphocytes obtained from other tissues. The results show that BTC belong to poorly adhering cells. However, their adherence was increased about 3-fold, when EC were pretreated with IFN-gamma, TNF-alpha or LPS. This adherence was very similar to that observed for lymph node T cells (LNTC) and 2-3 times lower than the adherence of spleen T cells (SpTC) and peritoneal exudate T cells (PETC). In some experiments, T lymphocytes were incubated for 1 h with concanavalin A (Con A) and this led to the highest increase of BTC adherence, but the enhancement of the adherence was significantly smaller than the increase noted for SpTC and PETC. The differences in the adherence of lymphocytes isolated from various tissues may suggest that different adhesion molecules are responsible for their binding to EC.

Animals↗
PubMed1993

[Immunoregulating properties of histamine H2 receptor antagonists].

The clinical aspects and their possible implication in the several disease treatment have been reviewed in the context of the immunomodulatory H2-receptor antagonist action. The therapeutical possibility considering the perspectives of the application of the H2-receptor blockers has been discussed.

Animals↗
PubMed1993

[Blood serum lipoproteins in overhaul workers of the chemical plant at Jaworzno].

For the evaluation of fat metabolism in 45 overhaul workers of a chemical plant producing pesticides, the serum concentration of total cholesterol and its LDL nd HDL fraction (also HDL2 and HDL3), apolipoprotein A and B, phospholipids and triglycerides were estimated. As compared to the results in the control group of healthy inhabitants of the region, occupationally not exposed to chemical agents, higher levels of total and LDL cholesterol, apolipoprotein A, total and LDL phospholipids, as well as triglycerides were found. Serum HDL2 cholesterol concentration was also, though insignificantly elevated. Such lipoprotein distribution can promote atherogenesis.

Adult↗
PubMed1992

Effect of T cell activation on lymphocyte-endothelial cell adherence and the role of VLA-4 in the rat.

Lymphocyte migration from the blood is in part controlled by lymphocyte surface adhesion molecules, such as VLA-4 and LFA-1. Small lymph node lymphocytes from rats adhere poorly to rat microvascular endothelial cells (EC), while lymphoblasts from antigen-challenged lymph nodes have an enhanced adherence to EC and preferentially migrate to inflamed tissues. This lymphoblast adherence is partially inhibited by anti-VLA-4. The effects of in vitro activation of lymph node lymphocytes on lymphocyte-EC adhesion were examined. In vitro stimulation of T cells with concanavalin A or calcium ionophore and phorbol myristate acetate (PMA) for 1-4 hr caused a marked (7- to 12-fold) increase in lymphocyte adhesion to unstimulated and IFN-gamma- or LPS-treated EC. This adhesion was partially inhibited by anti-VLA-4, was not associated with increased VLA-4 expression, was partially inhibited at 4 degrees C, and was virtually eliminated at 4 degrees C with anti-VLA-4. Anti-CD3 or IL-2 stimulation of T cells also enhanced lymphocyte adhesion but required 2-3 days of culture. This adhesion was not inhibited by anti-VLA-4 and was almost totally inhibited at 4 degrees C, suggesting a primarily LFA-1-mediated adhesion. In conclusion, stimulation of T cells with Con A or calcium ionophore plus PMA caused a rapid enhancement of lymphocyte-EC adhesion mediated in part through VLA-4, while stimulation of T cells with anti-CD3 or IL-2 enhanced lymphocyte adhesion apparently independent of VLA-4.

Animals↗
PubMed1992

[Difficulties in diagnosing a case of typhoid fever].

A sporadic case of typhoid fever of 41 years of age male was characterized clinically mainly with long duration of fever and a few enlargement of liver. Diagnosis was made relatively late. In this case an endoscopic picture of upper gastrointestinal tract and ultrasonographic findings of the organs of abdominal cavity was described.

Abdomen↗
PubMed1992

The influence of thymus extracts on the chemotaxis of polymorphonuclear neutrophils (PMN) from patients with insulin-dependent diabetes mellitus (IDD).

The main goal of this study was to evaluate the possible influence of thymus extracts on the chemotaxis of PMN isolated from diabetic patients. The analyzed group consisted of fifty patients with insulin-dependent diabetes mellitus (IDD), and twenty healthy adults were taken as controls. The results showed, that PMN isolated from patients with IDD manifested the impaired chemotaxis toward zymosan-activated plasma (ZAP), plasma incubated with cellophane and supernate from E. coli culture. Both thymus extracts did not change the directed migration toward control plasma and toward ZAP. THYMEX-L did improve the migration of diabetic PMN toward plasma incubated with cellophane, whereas TFX-THYMOMODULIN ameliorated the impaired chemotaxis toward supernate from E. coli culture. Both thymus extracts can attract PMN obtained from healthy donors, but not the cells isolated from diabetic patients.

Adolescent↗
PubMed1987

Effect of organophosphoric pesticides on the behaviour of NBT-dye reduction and E rosette formation tests in human blood.

Investigations have been undertaken to determine the effect of occupational exposure to organophosphoric pesticides on the behaviour of NBT-dye reduction and spontaneous E rosette formation tests. A significant decrease of the values of the examined cellular parameters of human immunity and of the absolute lymphocyte count in peripheral blood was found in 31 workers, as compared to 30 controls. Moreover, the NBT-dye reduction decrease showed a positive linear correlation with a reduced acetylcholinesterase (AChE) activity. The exposure time showed a negative linear correlation of the phagocytic index of the NBT-dye reduction test. It is concluded that depressed NBT-dye reduction and diminished spontaneous E rosette formation may be regarded as a probable mode of the effect of organophosphoric chemicals on metabolic and membrane damage of human cells. A possible role of endogenous acetylcholine poisoning in the development of these pathologic conditions is also discussed.

Acetylcholinesterase↗