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Biomedical subjects

J Witte

Publications and source records attributed to J Witte.

At least 109 records · Page 6Linked to original sources
PubMed1985

[Malnutrition and anemia in children hospitalized in Martinique].

In order to assess prevalences, characteristics and risk factors of malnutrition and anemia, a clinical and biological study was undertaken at Lamentin hospital in 100 hospitalized children aged 6 months to 6 years. Forty seven p. cent of children were underweight and 38 p. cent were anemic. Anemia and iron deficiency predominated in the under-24-month age group, whereas wasting was the dominate finding in older children. Under 2 years of age, risk factors for wasting and anemia were associated with method of breastfeeding. Over 2 years of age, low birthweight was the only risk factor of wasting identified. In Martinique, nutritional deficiency is common in children admitted to hospital and a high index of suspicion is indicated in the hospitalized population. Following the resolution of infections, supplemental iron therapy must be considered for a great number of children under 2 years of age.

Anemia↗
PubMed1982

Disturbances of selected plasma proteins in hyperdynamic septic shock.

This study was performed on patients (n = 18) suffering from strictly defined hyperdynamic septic shock. Plasma factors (C-reactive protein, acid alpha 1-glycoprotein, fibrinogen, fibrinopeptide A, fibrinogen-fibrin split products, factor XIII, antithrombin III, complement factors C3 and C4, inter-alpha-trypsin-inhibitor and alpha 2-macroglobulin) measured during hyperdynamic septic shock were highly abnormal. The activation and consumption of clotting, fibrinolytic and complement factors due to system-specific proteinases (such as thrombokinase or plasminogen activators) seemed to be intensified by the nonspecific proteolytic activity of granulocytic proteinases probably released by the action of endotoxins. Possible therapeutic measures to maintain the endogeneous defence mechanism against enhanced proteolysis during septic shock are discussed.

Alpha-Globulins↗
PubMed1982

Post-menopausal concentrations of plasma oestradiol, oestrone, FSH and LH and of total urinary oestradiol and oestrone after a single sublingual dose of oestradiol-17 beta.

We report the effects of sublingual absorption of a single dose (0.5 mg) of oestradiol-17 beta (E2) in 8 post-menopausal women, on plasma E2 and oestrone (E1), urine elimination of total E2 + E1 and on plasma FSH and LH. The results show that sublingual absorption of E2 occurs and that plasma concentrations of E2 obtained (between 133.2 to 320 pmol/l) in this way were higher than those obtained after percutaneous absorption of a single dose (3 mg) of E2. The ratio E1/E2 in plasma is close to that of pre-menopausal women.

Absorption↗
PubMed1982

[Postoperative syndromes after surgery for termination of esophageal reflux (author's transl)].

Postoperative syndromes after surgery for termination of esophageal reflux may be due to false indication for surgery, technical faults, functional disturbance after other surgical procedures, non-related accompanying disease, or relapse of reflux esophagitis. Only an exact analysis of the factors causing the syndrome will allow in the individual case an appropriate therapy. Management should be medical in most cases; only such patients should be operated upon again, which do have symptoms of distinct severeness and long duration. In patients, which had an anatomical reconstruction done during the first surgical procedure, the therapy of choice is establishing a valvuloplasty. Has this been done as the first surgical procedure, the fundoplication must be untied, and a new surgical trial to terminate esophageal reflux has to be done.

Deglutition Disorders↗
PubMed1981

Clotting and other plasma factors in experimental endotoxemia: inhibition of degradation by exogenous proteinase inhibitors.

Endotoxemia in dogs was induced by a slow intravenous infusion of E. coli endotoxin for 2 h. Thereby, a significant decrease was observed in the plasma levels of several clotting, fibrinolysis and complement factors. The changes were studied over an experimental period of 14 h and checked for statistical significance by three-way analysis of variance. Application of the broad-spectrum proteinase inhibitor aprotinin (Trasylol) from bovine organs clearly lowered the endotoxin-induced decline of the plasma proteins studied. By intravenous application of a specific granulocytic proteinase inhibitor (Bowman-Birk inhibitor from soybeans), the endotoxin-induced reduction of the plasma proteins was prevented in a similar manner. It can be concluded that at least some of the pathobiochemical mechanisms observed in clotting, fibrinolysis and complement systems during endotoxemia are not only caused by a severe consumption reaction but also by unspecific proteolytic degradation due to neutral granulocytic proteinases.

Animals↗
PubMed1980

[The significance of exogenous sodium uptake in the perioperative homeostasis of the water and electrolyte balance].

In 13 surgical patients who underwent abdominal surgery of moderate degree it has been shown that postoperative sodium substitution of normal range (1.5 m eq/kg bw. .24 h) led to hyponatremia and aldosteronism with Na+ and water retention. Aldosteronism was strongly correlated to increased activity of the renin-angiotensin-system, both anteceded by restriction of the extracellular space and expansion of total body water. These were controlled by a high sodium input (5 m eq/kg bw. .24 h) without changing the volume infusion, which is demonstrated by suppressed renin and aldosterone secretion rates, improved diuresis and subsequent reduction of total body water in favor of a preserved functional extracellular space. In order to avoid inadequate fluid redistribution it seems reasonable to meet the patient's postoperative sodium requirements by increased sodium input.

Abdomen↗
PubMed1980

[Surgery of rectal carcinoma (author's transl)].

The absolute number of deaths caused by rectal carcinomas has greatly increased in the FRG within the last 10 years. However in relation to the age of the patients the rate per 100 000 inhabitants did not change. The results of an operative treatment could only be improved slightly because there is still a delay in diagnosis. Despite a high rate of false negative results (34,1%) the hemoccult-test has been used most frequently as a preoperative diagnostic test. Other biochemical parameters could not replace this test. Nowadays orthograde lavage can be considered as the best preoperative treatment of the bowel. As to the comparison of the prognosis after reaction of the rectum or exstirpation, there remains the problem of preselecting the patients. The indication for resection seems to increase by using staplers. New operative techniques for colostomy and its postoperative care after exstirpating the rectum may provide further improvement for the patients. In nonoperable carcinomas a colostomy can be avoided by using cryosurgery in 2/3 of all patients. So far, surgical results could not be improved by early additional chemotherapy.

Adult↗
PubMed1979

The optimization of the pulse delivered by the pacemaker.

The results of stimulation threshold analysis carried out in 230 patients after the initial electrode implantation, and in 188 patients during pacemaker replacement, are presented. The electrodes investigated were the IE-60K-10 (279 cases), the IE-60-K (96 cases) and the ME-50 (26 cases). The chronic stimulation threshold voltage for the electrode IE-60K-10 (electrode surface area: 10 mm2) at a pulse width of 0.5 ms, after an electrode function time of 25 months, is 2.05 +/- 0.18 V, representing 256% of the acute threshold, and is equally as high as the chronic figure for the IE-60-K electrode (surface area: 27 mm2) measured at 2.08 +/- 0.20 V. The current threshold for the IE-60K-10 increased from 0.78 +/- 0.07 mA by 299% to 2.33 +/- 0.30 mA and was thus, as expected, lower than that of the large area electrode IE-60-K, which increased from 1.11 +/- 0.22 mA to 3.23 +/- 0.43 mA (291%). On the basis of the computation of the stimulation threshold energy and the stimulation threshold charge, a reduction of pulse duration to below 0.5 ms would not appear to make such energy-saving sense.

Electrodes, Implanted↗
PubMed1979

[Hyperdynamic septic shock in man: concentration course of selected coagulation factors and plasma proteins].

Coagulation factors and plasma proteins are significantly decreased in patients with hyperdynamic septic shock. Besides the activation of the coagulation system, the endotoxin-induced release of granulocyte proteases is responsible for a septic disseminated intravascular coagulation. In this situation special emphasis should be placed on the levels of antithrombin III regarding application of heparin.

Antithrombin III↗
PubMed1978

[Significance of diagnostic procedures in reflux esophagitis (author's transl)].

The diagnosis of reflux esophagitis can be confirmed by a variety of diagnostic procedures. Beside the morphologic findings of the reflux demonstrated by X-ray, endoscopy, and histology, the degree of disturbed cardial function can be determined by manometry, pH determination, and scintiscan. Each method entails a number of errors. Therefore a distinction must be made between absolutely necessary and valuable methods for clarifying the degree of the symptoms of esophageal reflux.

Biopsy↗