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Biomedical subjects

J Winberg

Publications and source records attributed to J Winberg.

At least 127 records · Page 7Linked to original sources
PubMed1973

Hypertension, asymmetric renal parenchymal defect, sterile urine, and high E. coli antibody titre.

During an 11-year period four children were seen with asymmetric renal parenchymal reduction, arterial hypertension, and sterile urine. The history and radio-logical or histological findings, or both, were consistent with "abacterial pyelonephritis" induced by bacterial infection in early childhood. All four had raised antibody titres to Escherichia coli. Three possibilities may explain the high antibody titres and insidious course of the renal damage-the presence of bacterial variants or amorphous bacterial antigen in the kidneys or the fact that because of cross-reactivity between certain E. coli O antigens and renal tissue the "E. coli antibodies" were, in fact, autoantibodies.

Adolescent↗
PubMed1970

Resistant urinary infections resulting from changes in resistance pattern of faecal flora induced by sulphonamide and hospital environment.

The faecal flora was studied in eight children admitted to hospital for treatment of a first urinary infection with sulphonamides. The original, sulphonamide-sensitive Escherichia coli organisms were found to disappear, to be replaced by other E. coli serotypes that were almost invariably resistant to sulphonamides. Some of these serotypes carried R-factors for multiple antibiotic resistance.Possibly some urinary infections with antibiotic-resistant organisms may be due to faecal organisms whose resistance has been changed by previous antibiotic treatment. Hence it is important to study the effects of individual antibiotics on the faecal flora.

Drug Resistance, Microbial↗