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Biomedical subjects

J Wilson

Publications and source records attributed to J Wilson.

1,040 records · Page 58Linked to original sources
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Rheumatoid nodulosis. Sporadic and familial diseases.

Two patients are described with longstanding, multiple, subcutaneous nodules with the histopathological features of rheumatoid nodules. Neither patient had any clinical evidence of rheumatic disease. One patient had a family history of smiliar nodules transmitted as an autosomal dominant trait. Leukocyte function studies failed to reveal any defect to account for the nodule formation.

Female↗
PubMedDate not supplied

Haemodynamic effects of selective alpha 1-blockade (trimazosin) in essential hypertension.

As a preliminary to a larger clinical trial, the haemodynamic effects of the selective alpha 1-adrenoceptor antagonist trimazosin were studied at rest and during bicycle exercise in the upright position in 14 patients with uncomplicated, stable essential hypertension. Rest and exercise studies before the drug was given revealed no evidence of left ventricular pumping deficiency. A single intravenous bolus of trimazosin (2 mg/kg) resulted in a plasma concentration of 13.1 +/- 1.0 mg/ml 30 min after injection. This plasma concentration of trimazosin was associated with a reduction in the systemic vascular resistance (p less than 0.01); in the absence of any increase in the cardiac output, this resulted in a fall in the systemic blood pressure (p less than 0.01) at rest. Heart rate and left heart filling pressure were unchanged. During 4 min of upright dynamic exercise after drug, the increment in systemic blood pressure was similar to that in the control study; i.e., the absolute level of pressure was reduced (p less than 0.01). The increases in heart rate, cardiac output, and left heart filling pressure during exercise were also unchanged after drug compared with those measured in the control study. The left heart filling pressure and cardiac output were slower to increase at the onset of exercise after trimazosin, which may imply a degree of venodilatation. There were no hypotensive symptoms or large falls in blood pressure after trimazosin at rest, but following 4 min of submaximal upright bicycle exercise, three of the 14 patients developed postural hypotension.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Effects of design features and restorative techniques on marginal leakage of MO composites: an in vitro study.

Effects of clinical practices on marginal leakage of MO composite restorations were studied in vitro. Three design scenarios and three restorative techniques were studied. A total of 45 premolars were used, providing five specimens for each of the nine design-technique permutations. The extent of marginal leakage was measured under magnification, after soaking the samples in a dye and then sectioning each sample mesiodistally. No significant differences were found between the permutation groups, although some clinical practices resulted in a lowered mean amount of marginal leakage.

Analysis of Variance↗