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Biomedical subjects

J Willis

Publications and source records attributed to J Willis.

At least 127 records · Page 7Linked to original sources
PubMed1972

A portable device for group modification of classroom attending behavior.

There is a need for a portable means of signalling appropriate classroom behavior that the teacher can carry with her as she moves about the room. An inexpensive wireless switch, adapted for classroom use, was used to turn on a clock when all children were attending to their work. When a movie was made contingent on accumulating a specific number of minutes on the clock, class-attending increased. Throughout these conditions, the records of class attending made by an independent observer with a stopwatch correlated highly with the remote controlled clock.

Journal Article↗
PubMed1966

[Not Available].

Explore the source record for details and available documents.

History, Ancient↗
PubMedDate not supplied

Short-latency somatosensory evoked potentials in perinatal asphyxia.

Ten asphyxiated term newborns were studied in the first 6 months of life with median nerve short-latency somatosensory evoked potentials (SLSEP) and followed subsequently to a mean age of 20 months. Results of SLSEP correlated with subsequent outcome in every patient; normal and abnormal infants at subsequent examination were separable on the basis of prior SLSEP, although the severity of later disability could not be inferred from SLSEP.

Asphyxia Neonatorum↗
PubMedDate not supplied

Sperm DNA integrity: correlation with sperm plasma membrane integrity in semen evaluated for male infertility.

Previous independent studies have indicated that abnormally low parameters of sperm DNA integrity and sperm membrane integrity correlate to reduced fertility due in part to implantation disorders. The purpose of our study was to evaluate the relationship between sperm plasma membrane functional integrity assessed by the hypo-osmotic swelling test (HOST) and sperm DNA integriy test assesed by DNA fragmentation index (DFI). Semen samples from 102 random patients were evaluated in terms of standard semen parameters and assessed by DFI and HOST. Both tests showed a significant correlation to standard semen parameters (p < .05). In addition, patients with abnormal HOST results had a higher likehood of a subnormal or abnormal DFI result (p < .001). Our results suggest that a common sublethal insult may manifest as abnormalities in both the nucleus and the plasma membrane that act at the implantation and/or subsequent levels of development rather than at the fertilization stage.

Adult↗
PubMedDate not supplied

Birth fractures in spinal muscular atrophy.

Three patients with birth fractures and Werdnig-Hoffmann disease are presented. Two of the three were erroneously diagnosed as having osteogenesis imperfecta. The etiology of these fractures appears to be in utero osteoporosis secondary to decreased movement, leading to pathologic fracture during birth. Immobilization led to uneventful healing in all cases; no recurrent fractures were seen.

Birth Injuries↗
PubMedDate not supplied

Vagus nerve stimulation for treatment of partial seizures: 2. Safety, side effects, and tolerability. First International Vagus Nerve Stimulation Study Group.

Vagus nerve stimulation (VNS) significantly reduces the frequency of partial seizures in refractory epilepsy patients. We examined the serious adverse events, side effects, and tolerability as they relate to the surgical implant procedure and the stimulating device. We also reviewed potential drug interactions, device output complications, and impact of the therapy on overall health status. We analyzed the first 67 patients to exist the acute phase of the EO3 VNS trial comparing high (therapeutic) VNS to low (less or noneffective) VNS. Data were collected from case report forms used at each of the four visits during the 12-week baseline and at each of the four visits during the 14-week randomized phase of the trial. No significant complications were reported as a result of the implant procedure. Serious adverse events included 1 patient who experienced direct current to the vagus nerve owing to generator malfunction resulting in left vocal cord paralysis and withdrawal of the patient from the study. No clinically significant effects on vital signs, cardiac function, or gastric function were detected. Side effects associated with VNS in the high group were hoarseness (35.5%), coughing (13.9%), and throat pain (12.9%). In the low group, only hoarseness (13.9%) and throat pain (13.9%) were associated with VNS. These effects generally wrre not considered clinically significant and occurred primarily during the stimulation pulses. No patients discontinued VNS therapy during the acute phase because of side effects associated with normal stimulation. Except for the one instance of a short circuit in the system resulting in a direct current, stimulating system complications were minor, limited to programming, unscheduled stimulation, and high lead impedance. Patients, investigators, and patient companions rated patients receiving high stimulation as more "improved" than those receiving low stimulation in regards to overall health status. Antiepileptic drug (AED) plasma concentrations were not affected by VNS. The implant procedure, stimulating system, and therapy proved safe and tolerable during the study. The high percentage (67 of 68) of patients completing the study reflects patient acceptance and tolerability of this mode of therapy.

Adolescent↗