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Biomedical subjects

J Willis

Publications and source records attributed to J Willis.

At least 109 records · Page 6Linked to original sources
PubMed1981

Paraplegia due to peripheral venous air embolus in a neonate: a case report.

A term male infant with pneumonia was receiving fluid and antibiotics through an intravenous line in the scalp. Air was accidentally infused in this line. Subsequently, discoloration of the skin, a flaccid paraplegia, hematuria, and gastrointestinal bleeding occurred as the presumed effect of venous air entering the systemic arteries. The umbilical vessels were never catheterized. Absence of any apparent cerebral air embolism is interpreted as being due to the infant's position (head down) at the time of air infusion. The pathogenesis and prevention of this tragic complication are discussed.

Anti-Bacterial Agents↗
PubMed1980

The Aicardi syndrome versus congenital infection: diagnostic considerations.

The Aicardi syndrome consists of agenesis of the corpus callosum, infantile spasms, a characteristic lacunar chorioretinopathy, mental subnormality, and costovertebral anomalies. All patients have been female. Its clinical similarity to several congenital intrauterine infections, particularly toxoplasmosis, is reinforced by the erroneous diagnosis of congenital infection initially made in the two patients reported here. Reasons for this confusion are outlined, and methods for a clinical differentiation between the Aicardi syndrome and the congenital infections are discussed.

Abnormalities, Multiple↗
PubMed1980

Periodic alpha seizures with apnea in a newborn.

A post-mature female newborn with a history of birth trauma developed frequent apneic spells coincident with left posterior-quadrant alpha discharges on her electro-encephalogram. Except during apneic spells, clinical seizure activity was rare. The alpha discharges occurred at regular intervals and were associated with disrupted sleep cycles and a diminution in the proportion of quiet sleep. Phenobarbital apparently abolished the apnea and alpha discharges and resulted in normal sleep cycles and state proportions. At 20 months of age the patient is neurologically and developmentally normal. She has been free of apnea and seizures since the newborn period, despite withdrawal of the anticonvulsant at eight months of age. The authors relate her favorable course to the etiology, periodicity and therapeutic response of her clinical and electrical seizures.

Alpha Rhythm↗
PubMed1978

CPQ validity: the relationship between children's personality questionnaire scores and teacher ratings.

Scores on the Children's Personality Questionnaire (CPQ) were correlated with scores from rating scale items selected by a panel of raters measuring the same behavior as a CPQ scale. Data were obtained on a normal sample of school children in grades three to six and on two referred groups, underachievers and children with behavior or social problems. The teachers of the children were asked to complete two rating scales on each child. Correlations between rating scale scores and CPQ scores suggest that, in general, the CPQ does not measure the traits it purports to measure.

Cattell Personality Factor Questionnaire↗
PubMed1975

Tangible reinforcement and feedback effects on the IQ scores of college students.

College students who retook an intelligence test under conditions that informed the student of each correct answer made significantly higher gains than a control group that retook the test under standard conditions. A group that retook the test under feedback and reward conditions did not differ significantly from the control group.

Age Factors↗
PubMed1975

The offset of morphine tolerance in rats and mice.

1. In rats and mice made tolerant to morphine by pretreatment with the drug, the shift to the right of the log dose/analgesic response line for in naive animals occurs without significant change in slope provided that sufficient time is allowed for elimination of pretreatment drug. 2. Responsiveness to the analgesic effects of morphine, given together with cycloheximide to prevent reinforcement of tolerance, was measured in rats (paw pressure method) and mice (hot plate method) at intervals during 1-23 days following cessation of a variety of regimens of tolerance-inducing drug treatments. 3. A biphasic pattern of recovery of responsiveness was observed, which was independent of the regimen or the drug (morphine, methadone or diamorphine) used to induce tolerance. Estimates of the rates of the first, fast phase are imprecise but the rate of the second phase of offset, from 4th day after cessation of pretreatment had, in rats, a mean half-time of 13.2 plus or minus 0.53 days-for all pretreatments combined, there being no significant differences between the various pretreatment regimens employed. In mice, similarly, a biphasic recovery of analgesic responsiveness was seen after morphine pretreatment, the mean half-time of the slower phase being 17.4 days. 4. Precipitation of an acute withdrawal syndrome in rats by naloxone HCl given 6 h after the final injection of a tolerance-inducing treatment with morphine did not affect the subsequent rate of recovery from tolerance. 5. During the period following a tolerance-inducing pretreatment with morphine in mice, the rate of attenuation of the naloxone-evoked jumping response was faster than the rate of offset of tolerance.

Analgesics↗