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Biomedical subjects

J Weber

Publications and source records attributed to J Weber.

At least 739 records · Page 41Linked to original sources
PubMed1975

[Heart and altitude].

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Adaptation, Physiological↗
PubMed1975

[Our experience with the radioimmunoassay of insulin: Its practical value. Apropos of 140 cases].

What is the interest of insulin determinations in diabetics? The interest is considerable, scientifically, particularly in obese patients with hyperinsulinism. In practice, in intermediate cases of diabetes, it may help in deciding whether or not to administer insulin. The authors studied insulin secretion in various varieties of diabetes and its role in the onset of vascular complications. Low insulin secretion seems to favour the development and frequency of the latter.

Adult↗
PubMed1975

Genetic analysis of adenovirus type 2. I. Isolation and genetic characterization of temperature-sensitive mutants.

Temperature-sensitive mutants which replicate normally at 33 C but poorly at 39 C were isolated from nitrosoguanidine- or nitrous acid-mutagenized adenovirus 2 by (i) testing the cytopathic effect or inclusion body-forming capacity of random plaque isolates, or (ii) reduced plaque enlargement upon shifting from 33 to 39 C. Thirty-six mutants were isolated with 33 C/39 C plaque ratios varying from 20 to 10-5. Some of these mutants could be arranged into 13 groups by the complementation test. By means of recombination analysis a provisional linear genetic map was constructed.

Adenoviridae↗
PubMed1975

Genetic Analysis of Adenovirus Type 2 II. Preliminary Phenotypic Characterization of Temperature-Sensitive Mutants.

The properties of temperature-sensitive mutants of adenovirus type 2 representing 12 complementation groups were studied. All mutants were normal with respect to adsorption as measured by viral inclusion formation and viral DNA synthesis as shown by velocity sedimentation in alkaline sucrose gradients. One mutant, however, formed viral inclusions of altered morphology at the nonpermissive temperature. The synthesis of the major capsid proteins was examined by immunodiffusion. On this basis, the complementation groups could be arranged as follows: (i) one group was negative for all three proteins; (ii) three groups failed to synthesize penton bases; (iii) eight groups were positive for hexons, pentons, and fibers. The assembly of virus particles at 39 C was examined by equilibrium sedimentation in CsCl; three groups were found defective, whereas two of the penton-negative groups were positive for virion production. Tests of the thermolability of virions at 50 C revealed eight groups labile whereas the remainder were insensitive to heat inactivation. None of five mutants inoculated in newborn rats induced tumors, although three of them were capable of in vitro transformation.

Journal Article↗
PubMed1975

[Neonatal asphyxia immediately following birth due to thyreoglossal cyst blocking the larynx (author's transl)].

Report on death from asphyxia immediately after birth of a child with obstruction of the larynx by a cyst of thyreoglossus. When intubation of an asphyctic neonate is attempted and a diagnosis of an obstructing cyst is made the following measures should be taken: Immediate aspiration of the contents of the cyst or without canula under laryngoscopic control. Attempt at intubation. If unsuccessful, emergency tracheostomy, although burdened with a high morbidity in neonates. If this cannot be done quickly, then--in addition to other measures--an infusion should be given through a catheter in the umbilical vein to counteract acidosis and hypercapnia.

Asphyxia Neonatorum↗
PubMed1975

[Bilateral abscessing coil-pneumonia with aspergillus-superinfection and unknown metastasing bronchial carcinoma (author's transl)].

A report on a 43-years old patient who fell ill with a bilateral abscessing coli-pneumonia with secondary aspergillus settlement. After a 10-week treatment with a continuous progression of the lung lesions the patient died of a respiratory insufficiency. At autopsy a multilocular metastasing squamous cell carcinoma has been found in both upper lobes of the lungs as the primary disease.

Adult↗