Biomedical subjects

J Wasserman

Publications and source records attributed to J Wasserman.

At least 163 records · Page 9Linked to original sources

PubMed1976

Rapidly progressive glomerulonephritis with antibodies against glomerular basement membranes in serum and kidneys.

Four cases of rapidly progressive glomerulonephritis with similar clinical courses are presented. Examination of kidney biopsies from these patients showed severe glomerulitis with capillary necrosis, fibrin thrombi and interstitial inflammation but no vasculitis. Electron microscopy showed wrinkled capillary basement membranes which were irregularly thickened, homogenous and had an irregular fibrillar structure. No localized deposits were observed. Immunohistological examination demonstrated linear and diffuse deposition of IgG and C3 along glomerular basement membranes. Nephrectomized kidneys from these patients were eluted and shown to contain antibodies against glomerular basement membrane. These antibodies were also present in sera of three of the patients.

Adolescent↗

PubMed1975

Capacity of sera from patients with mammary carcinoma to promote PHA-stimulation of human lymphocytes.

Lymphocytes from patients with carcinoma have been reported to exhibit impaired immunologic reactivity and responsiveness to non-specific stimuli both in vivo and in vitro due to inhibitory serum factors. In the present investigation it is tested whether sera from patients with mammary carcinoma may inhibit the response of lymphocytes from normal donors to phytohaemagglutinin (PHA) in vitro. Neither sera from patients with newly diagnosed breast malignancy nor patients with wide spread disease differed from control patients with benign breast lesions. Serum activity did not change within 3 weeks after radical mastectomy or local irradiation but increased slightly after 6 weeks. It is suggested that the impaired PHA-responsiveness of lymphocytes in patients with mammary carcinoma is not due to blocking serum factors but to intrinsic cellular abnormality.

Adult↗

PubMed1975

Autoantibodies in patients with carcinoma of the breast. Correlation with prognosis.

Sera from a hundred patients with operable carcinoma of the breast and seventy-five age-matched controls were examined for antinuclear, smooth muscle, glomerular and mitochondrial antibodies by indirect immunofluorescence technique. Antinuclear and smooth muscle antibodies were found to be more frequent in cancer patients than in controls. The incidence of autoantibodies at the time the diagnosis was established was higher in patients who developed local recurrences or distant metastases within 2 years than in patients free from recurrence.

Antibodies, Antinuclear↗

PubMed1975

Effect of radiotherapy on lymphocyte cytotoxicity in vitro.

The cytotoxic functions of highly purified blood lymphocytes from patients with breast cancer were studied before and after radiotherapy. Addition of PHA or of rabbit antibodies to target cells (chicken erythrocytes) were chosen as two means of inducing lymphocyte cytotoxicity in vitro. The proportion of T and non-T-lymphocytes was determined by means of E and EAC rosette tests. The antibody-induced cytotoxocity of lymphocytes decreased following radiotherapy while that mediated by PHA remained unchanged. There was some reduction in the percentage of EAC rosette-forming cells. These results, as well as our earlier observations, suggest that the decrease in the peripheral blood of the proportion of lymphocytes with receptors for activated complement is responsible for changes in the antibody-mediated lymphocyte cytotoxicity.

Adult↗

PubMed1974