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Biomedical subjects

J Waisman

Publications and source records attributed to J Waisman.

At least 55 records · Page 3Linked to original sources

Comparison of transrectal prostate digital aspiration and ultrasound-guided core biopsies in 99 men.

We compared digital transrectal needle aspiration and transrectal core prostate biopsies obtained with ultrasound guidance in 99 men. Both procedures were effective in identifying prostate cancer; complete sensitivity was 94 percent for aspiration and 90 percent for core biopsy. Aspiration confirmed 87 percent of 38 known cancers and 94 percent of 81 cancers overall, compared with 82 percent and 90 percent with core biopsies. The greatest number of cancers was found when both procedures were considered (95% of known and 98% of all cancers). Grading of both specimens was performed but was not equivalent. Unsatisfactory or inconclusive results by either procedure often obtained when cancer was present. We suggest digital transrectal needle aspiration as a first means of identifying most palpable prostate lesions. Transrectal core biopsies guided by ultrasonography should be used when suspicion of cancer cannot be confirmed by aspiration and when there is no palpable lesion (but clinical suspicion of cancer).

Adenocarcinoma↗

Carcinoid tumor of skin: report of a possible primary case.

A case of a possible primary carcinoid tumor of the skin in a 40-year-old man is presented. The neoplasm was diagnosed as consistent with carcinoid tumor on the basis of conventional light microscopy, immunohistochemical studies, and electron microscopy. Workup revealed no evidence of carcinoid tumor elsewhere. Metastases to the skin from internal carcinoid tumors are uncommon, but presumed primary carcinoid tumors that arise in the skin are extremely rare; only three cases have been found in the English-language literature.

Adult↗

Oncocytic renal tubular adenoma (so-called oncocytoma) in seventeen-year-old girl.

Renal tubular neoplasms (adenomas or adenocarcinomas) are rare in children or young adults. Herein, we report an oncocytic renal tubular adenoma (so-called oncocytoma) that was found in a seventeen-year-old girl. Preoperative evaluation included aspiration of this tumor, and we suggest that preoperative aspiration is an important procedure in the diagnosis and management of suspected renal tumors in children and young adults.

Adenoma↗

Comparison of fine-needle aspiration and frozen section of palpable mammary lesions.

We compared the results of 100 consecutive fine-needle aspirations of palpable mammary lesions in women with 100 consecutive frozen sections done on palpable suspicious nodules in the breasts of women who had had no prior aspiration. There were no false positive results in either group. The false negative rate of aspirations was 6%, compared with none for frozen section, suspicious cases excluded. In four of six patients with false negative aspirations, the specimen was nondiagnostic or unsatisfactory. (In this series, no repeat aspirations were performed for nondiagnostic or negative specimens, even when clinically suspicious.) We conclude that aspiration of a palpable mammary tumor is a definitive procedure with results equivalent to frozen section and equally suitable for choosing and undertaking definitive therapy, when positive. Negative results, viewed in an appropriate clinical context, also proved conclusive. Atypical or suspicious results at aspiration must be followed by repeat aspiration or excision, since these frequently prove positive; likewise, unsatisfactory or nonrepresentative aspirations must be investigated further, as indicated by the clinical evaluation.

Adult↗

Psychosocial outcomes of breast cancer therapies: lumpectomy versus mastectomy.

The psychological status of 50 patients who had been treated for breast cancer was assessed an average of 21 months after treatment. The patients were grouped according to major treatment modalities: mastectomy with breast reconstruction, mastectomy without breast reconstruction, or lumpectomy. Lumpectomy patients had a significantly more intact body image (p less than .008) and a greater sense of sexual desirability (p less than .009) than patients in the other groups. The patients did not differ on frequency of sexual relations or on emotional symptomatology. The results of this study generally validate those found in comparable studies showing that lumpectomy promotes a more intact body image but that no surgical procedure either produces or inhibits psychological symptomatology.

Adult↗

Angiosarcoma of kidney.

We describe a forty-six-year-old man who died of disseminated angiosarcoma ten months after a radical nephrectomy and postoperative radiation therapy for a renal angiosarcoma. We found 3 other well-documented reports of renal angiosarcoma, all in men. Two of the 3 cases previously reported also had a rapidly fatal course with hematogenous spread of the neoplasm following nephrectomy. Angiosarcoma of the kidney, although rare, is apparently a highly malignant fatal neoplasm, and effective therapy remains unknown.

Combined Modality Therapy↗

AIDS: an overview of the pathology.

This article reviews the findings at postmortem examination on AIDS and separately details the surgical pathology of the gastrointestinal tract, liver, lymph nodes, and skin in these patients. Emphasis is placed upon the light microscopic features of the specimens commonly received in surgical pathology so as the promote the ready diagnosis of this important and grave disorder.

Acquired Immunodeficiency Syndrome↗

Primary carcinoid tumor of testis with metastasis.

A primary carcinoid tumor of the testis metastatic to one preaortic lymph node in a forty-three-year-old man is reported. The case was of great clinical interest not only because of the extreme rarity of testicular carcinoid with metastasis but also because of a coincidental bacterial endocarditis.

Adult↗

Subepithelial hematoma of the renal pelvis (Antopol-Goldman lesion): a case report and review of the literature.

A 45-year-old woman presented with gross hematuria and pain in the right flank. Blood was found in the right renal pelvis with bleeding from the lower pole of the kidney. Partial nephrectomy revealed hematomas in and about the pelvis and calices, confirming the diagnosis of Antopol-Goldman lesion. The cause of the lesion remains uncertain, although renal trauma superimposed on a hyperplastic pelvic capillary network, secondary to analgesic abuse, is suspected.

Analgesics↗

Multilocular cyst of renal hilum.

A case of a multilocular cyst in a sixty-three-year-old woman is reported. The cyst was located in the hilum of a kidney and was distorted but did not involve the renal pelvis or parenchyma. Although unique in location, it fulfilled all the criteria for a multilocular renal cyst.

Female↗

Aspiration biopsy of prostate.

Needle biopsy of the prostate has been widely practiced for more than twenty-five years, whereas transrectal aspiration biopsy, first described fifty years ago, has not. We describe our experience using the transrectal aspiration biopsy and correlate the results with histologic studies of the prostate obtained by conventional needle biopsy and surgical specimens. Aspiration needle biopsy of the prostate has a high degree of diagnostic accuracy, it causes minimal inconvenience and discomfort, the results are rapidly available, the ease of entering the suspected area in the prostate is more precise than with conventional needle biopsy, and sampling of prostate can be greater. The disadvantages of aspiration biopsy are that the technique, being unfamiliar to most urologists, must be learned and requires an experienced cytologist for interpretation. Cytologic evaluation by aspiration biopsy and the histologic diagnosis by conventional needle biopsy are complementary.

Biopsy, Needle↗

Cutaneous and subcutaneous metastases from carcinoma of prostate.

Secondary cutaneous and subcutaneous metastases originating from a visceral carcinoma are relatively uncommon and are associated most frequently with mammary, pulmonary, renal, and colonic cancers. Cutaneous and subcutaneous deposits from cancer of the prostate must be classified as extremely rare, e.g., only one solitary cutaneous metastatic carcinoma of prostatic origin was seen among 136,017 surgical and postmortem specimens submitted to the department of pathology at UCLA Hospital from male patient thirty-five years of age and older during the years between 1955 and 1980. Recently we observed a second case. A discussion of these 2 cases and a review of the English literature are reported.

Adenocarcinoma↗

Papillary adenocarcinoma of ureter.

A well-differentiated papillary adenocarcinoma developed in a ureteral stump thirty-six years after nephrectomy and was associated with a combined transitional-epidermoid carcinoma in the urinary bladder. Carcinoma in a ureteral stump is not uncommon and should be suspected in patients with a ureteral stump and hematuria. The very rare adenocarcinoma of the ureter is typically papillary and is associated with urinary tract infection and stones. At present successful treatment requires the early identification and extirpation of the ureteral tumor and consideration of associated cancer elsewhere in the urinary tract.

Adenocarcinoma, Papillary↗

The significance of lymph nodal involvement in renal angiomyolipoma.

Renal angiomyolipoma, a benign tumor, can involve regional lymph nodes. Although this phenomenon has been reported previously followup information has been scant. We have treated 3 patients who had renal angiomyolipoma with nodal involvement and all had further evidence of tuberous sclerosis. Each patient had hematuria with flank pain and required nephrectomy. In the ensuing 3 to 11 years none of these patients has had evidence of further disease progression. Nodal involvement may reflect the multicentricity of angiomyolipoma or may represent a form of "benign metastasis" but it does not appear to be a harbinger of disease progression.

Adult↗

Liver scintigraphy in colon carcinoma: correlation with modified Duke pathological classification.

Hepatic scintigraphy was performed prior to surgical exploration in 89 patients with primary carcinoma of the large bowel. Of these patients, 26% had positive liver scans at the time the diagnosis was established. The presence or absence of liver metastasis by scintigraphic criteria was correlated with surgical findings, a modified Duke pathologic classification, and the presence of tumor markers. The sensitivity of hepatic scintigraphy was 96% and the specificity was 98%. A total of 63% of patients with abdominal lymph node involvement had positive liver scans while 4.6% of patients without lymph node involvement had positive scans. A total of 91% of patients with positive liver scans had positive abdominal nodes. Of 60 patients with normal liver scans, one (1.7%) had hepatic metastasis and 27% had tumor in regional lymph nodes. Hepatic scintigraphy is highly sensitive in detecting liver metastasis from large bowel carcinoma. However, a negative liver scan did not exclude abdominal lymph node spread.

Adult↗