Biomedical subjects

J W Petrozzi

Publications and source records attributed to J W Petrozzi.

At least 37 records · Page 2Linked to original sources

PubMed1978

Photochemotherapy of psoriasis (PUVA) without specialized equipment.

High intensity long ultraviolet light (UV-A) systems along with oral methoxsalen (8-methoxypsoralen [8-MOP]) have been dramatically successful in clearing long-standing psoriasis. Since this equipment is beyond the reach of many dermatologists, we have examined alternate ways of achieving the benefits of PUVA photochemotherapy. A total of 24 patients with psoriasis have been treated with ordinary fluorescent blacklights in a conventional Zimmerman cabinet. Fourteen patients' conditions (58%) were cleared completely and the conditions of three (12%) were more than 80% improved. We used higher doses of 8-MOP, starting with 50 mg, and increased the dosage further in 15 cases. In five instances, 80-mg levels were given. With certain modifications, it may be possible to attain satisfactory therapeutic results with ordinary equipment. Higher doses of 8-MOP may be necessary to compensate for the lower irradiance light source in some instances. However, wide-spread use of PUVA therapy cannot be recommended at this time until the long-term effects of this treatment become known.

Humans↗

PubMed1977

Pseudomonal balanitis.

Significant ecologic changes in the cutaneous flora during treatment may present a challenge both diagnostically and therapeutically. The development of an erosive balanitis due to Pseudomonas aeruginosa presented an example of such a microbiologic shift in the case reported. The eruption developed during treatment with topical antibacterial, antifungal, and corticosteroid agents. The sudden exacerbation of any balanitis while under treatment should alert the physician to the possibility of superinfection.

Adult↗

PubMed1977

Topical methoxsalen and blacklight in the treatment of psoriasis.

Thirty patients with recalcitrant psoriasis were treated with topical methoxsalen and blacklight (UVA). A 1% concentration either in an acetone, alcohol, propylene glycol vehicle, or hydrophilic ointment, USP, applied two hours before light exposure was highly effective. Twelve patients were completely cleared and nine were markedly improved in three to five weeks. Plaque-type and guttate psoriasis responded best while exfoliative psoriasis benefitted less. Maintenance of a phototoxic reaction in the lesion was necessary for total resolution. Topical methoxsalen and blacklight is feasible for outpatient treatment of plaque-type psoriasis of limited extent.

Administration, Topical↗

PubMed1976

Keratosis lichenoides chronica. Possible variant of lichen planus.

A chronic, asymptomatic, keratotic, papular eruption, present for 15 years and resistant to all modes of therapy, was observed in a 49-year-old woman. Many of the papules formed a reticulated configuration over the arms and legs. This case resembles several others that have been described in the literature under different names, ie, keratosis lichenoides chronica, porokeratosis striata, and lichen verrucosus et reticularis. It is likely that all of these names refer to the same condition, constituting a definite clinical entity, which, on the basis of histological study, may represent a variant of lichen planus.

Chronic Disease↗

PubMed1976

Generalized exfoliative dermatitis from ethylenediamine.

A patient with a history of allergic reaction to an antibiotic cream (Mycolog [mixture of nystatin, neomycin sulfate, gramicidin, and triamcinolone acetonide]) was treated with aminophylline. A generalized exfoliative dermatitis resulted. The reaction was attributable to ethylenediamine hydrochloride, which is a component of both agents. Recognition of the potential for systemic medications to induce similar reactions in patients who are allergic to related topical preparations is important when prescribing systemic agents.

Aminophylline↗

PubMed1976

Sweet's syndrome: unique local response to streptococcal antigen.

Although hypersensitivity has been postulated, the etiology of Sweet's syndrome has never been elucidated. In the present case intradermal tesing with viridans streptococcus led to an immediate reaction and reproduced a lesion clinically and histologically identical to that of the primary disease. Other bacterial and fungal antigens failed to elicit any response. These findings provide further support for the role of hypersensitivity in the pathogenesis of this disorder. It would appear that immediate or humoral immunit

Adult↗

PubMed1975

Topical colchicine therapy for recalcitrant psoriasis.

Once daily applications of 1.0% colchicine in hydrophilic ointment for 6 to 12 weeks produced substantial resolution of recalcitrant psoriatic plaques, especially those on the trunk. With occlusion, lower concentrations of the drug (0.25% and 0.50%) were usually effective. A thick viscous base (hydrophilic petrolatum) was more effective than a hydrophilic cream base (hydrophilic ointment), presumably because of greater occlusivity. Treatment with topically applied colchicine may be valuable when other measures fail to control localized thick plaques of psoriasis. Its use is still experimental and should be restricted to small areas until more is known about its percutaneous absorption.

Administration, Topical↗

PubMed1975

Nodular subcutaneous fat necrosis. A manifestation of silent pancreatitis.

A 57-year-old man with asymptomatic pancreatitis developed tender subcutaneous nodules with fat necrosis. These nodules were the sole clinical manifestation of the underlying disease. This case demonstrates that silent pancreatitis should be considered in the differential diagnosis of painful leg nodules.

Adipose Tissue↗

PubMed1975

Treatment of psoriasis with topically applied tretinoin and steroid ointment.

The sequential application of tretinoin and a corticosteroid ointment was considerably more effective in the treatment of plaque-type psoriasis than either drug alone in a pilot study. The best results were obtained with 0.3% tretinoin followed by a potent corticosteroid ointment. Combined therapy was particularly efficacious in steroid-resistant psoriasis, including that on the palms, elbows, and knees. Irritancy from the high-strength tretinoin was a potentially troublesome side-effect. Care must be taken to avoid drug contact on areas that are easily irritated.

Administration, Topical↗

PubMed1974