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Biomedical subjects

J W Petrozzi

Publications and source records attributed to J W Petrozzi.

At least 19 recordsLinked to original sources
PubMed1990

Regressing atypical histiocytosis. Aberrant prothymocyte differentiation, T-cell receptor gene rearrangements, and nodal involvement.

Two cases of regressing atypical histiocytosis were studied. New findings reported include the presence of CD1 epitope on large atypical histiocytoid cells and apparent early lymph node involvement. Because regressing atypical histiocytosis may demonstrate aberrant thymic differentiation antigen expression and T-cell receptor gene rearrangements, initial lymph node involvement, and eventuation in conventional lymphoma in some cases, the alternative term regressing-phase anaplastic lymphoma is proposed as a more accurate designation for this entity.

Aged↗
PubMed1985

UVB maintenance phototherapy in psoriasis.

Twenty-six patients with generalized stable plaque-type psoriasis were treated three to five times weekly with midwave fluorescent ultraviolet radiation (UVB) combined with either tar or lubricants. After clearing, patients received maintenance treatment with lubricant and UVB for a minimum of four weekly exposures, which were subsequently decreased in frequency. A shielded control site was observed. During maintenance treatments no prolongation in remissions with UVB maintenance could be demonstrated.

Humans↗
PubMed1983

Possible drug-induced pemphigus-like antibodies with the clinical manifestation of erythema multiforme.

A patient with bullae and target lesions on the extremities and mucous membranes was seen with the clinical picture of erythema multiforme following an episode of pneumonia and a course of penicillin G potassium and tobramycin sulfate therapy. An unusually high titer of intercellular circulating (IC) antibodies was identified in the serum by indirect immunofluorescence (IF) microscopy, but direct lesional IF microscopy study results were negative. These IC antibodies were not true pemphigus antibodies and can best be termed pemphigus-like antibodies. These antibodies were characterized by their ability to fix complement, in contrast to pemphigus antibodies, which apparently fail to do so.

Antibodies↗
PubMed1983

Topical steroids and UV radiation in psoriasis.

This study evaluates the benefits of a potent and midstrength topical steroid compared with simple lubricating agents when used in combination with erythemagenic doses of sunlamp fluorescent UV irradiation in psoriasis. Twenty-six patients were studied in a bilateral symmetrical comparison. No significant differences were observed between topical corticosteroids and lubricants in the number of patients achieving a 75% or greater resolution of psoriasis. Topical corticosteroids did not reduce the number of treatments required for clearing. We did not observe faster recurrences in sites treated with topical corticosteroids. More severe burns and slightly less effectiveness were noted in patients irradiated five times weekly compared with three.

Administration, Topical↗
PubMed1982

Ultraviolet phototherapy in psoriasis with hydrophilic ointment alone or with crude coal tar.

Plaques of 12 psoriatic patients treated with crude coal tar and ultraviolet irradiation were compared with symmetric areas treated with the same ultraviolet light (UVL) source and a hydrophilic ointment vehicle. Of the 12 patients, 10 received 75-100% clearing at both sites regardless whether the tar or the vehicle was applied. Treatment three times weekly was as effective as five times weekly. It was uncertain if the addition of UV-A irradiation to the UVL system in a small group using tar had a more beneficial effect.

Coal Tar↗
PubMed1981

Comparison of once-daily and twice-daily ultraviolet radiation treatments in psoriasis.

Nine patients with chronic, stable, plaque-type psoriasis were treated with coal tar and sunlamp fluorescent irradiation. Symmetrical plaques were used to compare the effects of one ultraviolet radiation (UVR) treatment daily with two UVR treatments daily. We could not demonstrate any substantial difference in response. The use of one UVR exposure daily, with coal tar, offers a convenient and cost-efficient method for an outpatient Goeckerman treatment.

Coal Tar↗
PubMed1980

Comb and brush acne.

Frequent combing or brushing of the hair may result in an exacerbation of existing acne or be the cause of localized acne. Because of today's hair styling habits and methods, this type of acne is commonly encountered but poorly appreciated by physicians. Patient education is the most important factor in the management of this condition. Comb and brush acne is another external factor to be added to the list of causes of "acne mechanica."

Acne Vulgaris↗
PubMed1980

Verrucae planae spread by electrolysis.

The following case report presents a patient in whom flat warts were spread by electrolysis. Since electrolysis is a common procedure, physicians should be aware of such an occurrence. Adequate examination and treatment before the patient undergoes electrolysis can eliminate this unwanted side effect.

Adult↗
PubMed1980

Cutaneous Hodgkin's disease.

The case reported herein documents the occurrence of cutaneous involvement in a patient with a long history of Hodgkin's disease. Despite severe pruritus and intermittent exacerbations of a multitude of specific and nonspecific skin lesions, associated with his underlying malignancy, the patient has done remarkably well for more than seven years. This demonstrates quite well that cutaneous involvement in Hodgkin's disease is not necessarily an ominous prognostic indicator. More intensive systemic chemotherapy and/or topical therapy is frequently effective in such patients.

Hodgkin Disease↗
PubMed1979

An immunosuppressive serum factor in widespread cutaneous dermatophytosis.

A patient had a widespread dermatophytosis and a serum factor that specifically suppressed his T-cell rosette formation and the phytohemagglutinin responsiveness of his lymphocytes. The patient was also unable to mount a delayed hypersensitivity reaction to a standard anergy panel, although he did exhibit an immediate type hypersensitivity reaction to the trichophytin skin test antigen. Although many immunosuppressed patients succumb to severe bacterial and fungal infections, it is our contention that in certain cases the infectious process itself may generate a serum factor that is capable of inducing immunosuppression, thereby rendering the patient susceptible to further spread of the infection.

B-Lymphocytes↗
PubMed1979

Topical methoxsalen administration and sunlamp fluorescent irradiation in psoriasis.

Analysis of standard fluorescent sunlamps (Westinghouse) indicates that in addition to UVB (290 to 320 nm), a considerable amount of UVA (320 to 400 nm) is also present in their emissions. Since the benefits of topical psoralen administration and UVA have already been demonstrated, and prior experience by ourselves and others with UVB has indicated that some psoriasis benefited from UVB alone, localized areas and plaques of 20 patients were treated with topical administration of psoralens and fluorescent sunlamp bulbs to determine if such a light source with this emission spectrum would be advantageous. Results indicated a total resolution in 17 of 20 patients after an average of 18 treatments. Adverse blistering phototoxic reactions and excessive hyperpigmentation were not encountered. The UVB erythema response of normal skin served as the guide to light dosage in the same manner as administration of the Goeckerman regimen. Therefore, the use of psoralens was very effective when combined with fluorescent sunlamp irradiation; however, the potential risks of photocarcinogenicity makes this treatment experimental and should be reserved for recalcitrant cases.

Administration, Topical↗
PubMed1979

Palmar-plantar lichen sclerosus et atrophicus.

A 57-year-old woman has had lichen sclerosus et atrophicus confined to the palms and soles for the past six years. Diagnosis was confirmed by histologic study. Our patient's disease has been resistant to therapy.

Biopsy↗
PubMed1979

Comparison of crude coal tar and topical methoxsalen in treatment of psoriasis.

Fluorescent sunlamp bulbs have been an effective light source for treatment of psoriasis when they are used in combination with crude coal tar. In addition to their ultraviolet B (UVB) emission, the spectral output of these bulbs contains a substantial amount of ultraviolet A (UVA). Prior testing with this light source and topically applied methoxsalen achieved excellent results in psoriasis. This study compared topically applied methoxsalen to crude coal tar in 16 patients who had plaque-type psoriasis, using the same fluorescent sunlamp source of irradiation. Fourteen of 16 patients had complete clearing of plaques when they were treated with methoxsalen, compared with six patients who had complete clearing with the tar treatment. These results indicate that the use of methoxsalen and ultraviolet light may be more effective than tar, when used as they were in this study. The advantages of a clean, white, nonstaining topical agent also makes outpatient therapy more cosmetically acceptable.

Coal Tar↗
PubMed1978

Updating the Goeckerman regimen for psoriasis.

Various components of the Goeckerman regimen were analysed. Although our findings are preliminary, they indicate several important observations: (1) Irradiation of tar treated patients with UVA compared to UVB showed the most efficacious wavelengths to be in the erythemic range (UVB). (2) A 1% concentration of crude coal tar was as effective as 5 and 25%.(3) Application of tar 2 h prior to irradiation was equivalent to overnight usage. (4) Little difference was noted between hydrophilic ointment and petrolatum as vehicles. (5) A tar gel was less beneficial than crude tar. The benefits of the Goeckerman therapy are derived from the intrinsic antipsoriatic effects of both tar and UVB. For some the combination is additive and necessary for clearing; for others either of the components may have great benefit alone. Our favourable results with UVB alone indicate that its effectiveness has been understated and poorly appreciated. Minimizing the time of tar application without loss of efficacy makes treatment adaptable to outpatient practice.

Coal Tar↗