In the present study the effects of intracerebroventricularly [icv] administered somatostatin [linear and cyclic], somatostatin3-6, somatostatin7-10 and des AA1,2,4,5,12,13 [D-Trp8] somatostatin [ODT8-SS] were investigated on electroconvulsive shock [ECS]-induced retrograde amnesia in rats. The ECS significantly decreased the foot shock-induced avoidance latency, and thus caused retrograde amnesia. Somatostatin [linear and cyclic] in a dose of 0.6 nM had no action on the ECS-induced retrograde amnesia, while in doses of 3 nM and [cyclic only] 6 nM it significantly prevented it. Somatostatin3-6, somatostatin7-10 and ODT8-SS in doses of 0.6, 3 and 6 nM had no effect on the ECS-induced amnesia. These results indicate that the whole sequence of the original somatostatin molecule is needed to block the ECS-caused retrograde amnesia.

Amnesia↗

PubMed1984

Comparative studies with somatostatin and cysteamine in different behavioral tests on rats.

In the present study the effects of somatostatin and cysteamine (a selective decreaser of the somatostatin level in the body) were compared in different behavioral tests on rats. Somatostatin inhibited the extinction of active avoidance behavior 8 hr and 24 hr after intracerebroventricular (ICV) treatment, while cysteamine facilitated it 4 hr and 8 hr after subcutaneous (SC) treatment. Somatostatin did not significantly influence the cysteamine-induced facilitation of the extinction. Somatostatin did not have a significant effect on T-maze spatial discrimination learning and reverse learning, whereas cysteamine markedly attenuated the performance 4 hr (1st day) after treatment. Somatostatin in a dose of 4 micrograms (ICV) increased the locomotor activity 10 min after treatment, while cysteamine markedly decreased all parameters of the open-field test. These effects of the drug had disappeared 24 hr after treatment. If different doses of somatostatin (4 micrograms or 10 micrograms ICV) were administered to cysteamine-pretreated rats, the peptide did not modify the drug-induced changes in the open-field test. The data suggest that the brain somatostatin might have a physiological role in the organization of certain types of behavior.

Animals↗

PubMed1984

Serotypes of Pasteurella haemolytica isolated from sheep, goats and calves.

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Animals↗

PubMed1984

Effect of somatostatin and its fragments on turning behaviour induced by unilateral substantia nigra lesion in the rat.

The effect of somatostatin and its two tetrapeptide fragments was investigated on turning activity induced by unilateral substantia nigra lesion in rats. Somatostatin in a dose of 0.6 nM had no action on the turning behavior, while a dose of 6 nM increased slightly while a dose of 12 nM significantly the contralateral turning. Cys-Lys-Asn-Phe and Phe-Trp-Lys-Thr had no action in low or high doses on the turning activity of the animals. The results suggest that somatostatin has a direct postsynaptic dopamine receptor stimulating effect. It seems that for dopamine receptor stimulating action the complete somatostatin molecule is needed.

Amphetamines↗

PubMed1984

Amyloidosis.

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Amyloid↗

PubMed1983

[Lung compliance in newborn infants with meconium aspiration syndrome requiring mechanical respiration].

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Humans↗

PubMed1983

Effects of continuous positive airway pressure on renal function in prematures.

The effects of continuous positive airway pressure respiratory therapy--used in centrencephalic apnea in premature infants--has been investigated at a value of +6 cm H2O end-expiratory pressure. The results showed a significantly decreased glomerular filtration rate, decreased sodium and hydrogen ion excretion and urine output, without changes in systemic blood pressure, pulse rate, and blood gas values. At +3 cm H2O end-expiratory pressure no changes were observed.

Apnea↗

PubMed1983

Comparison of ATPase activity of cardiac myosins from different species.

Ca2+--ATPase activity of myosins prepared from hearts with different shortening speeds was measured in order to determine whether an alteration in hydrolitic activity or in the affinity of myosin for its substrate, or both, may be responsible for the species differences in Ca2+--ATPase. The KM values of ATP for cardiac myosins from rat, guinea-pig and rabbit did not differ significantly, whereas the Vmax decreased in the following order: rat greater than guinea pig greater than rabbit. These facts lead us to assume that, in spite of a great similarity of the active centres of the these myosins, the catalytic sites may not be identical.

Adenosine Triphosphatases↗

PubMed1983