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Biomedical subjects

J Valk

Publications and source records attributed to J Valk.

At least 181 records · Page 10Linked to original sources

Ultrasound in follow-up of the postoperative brain. Preliminary report on six cases.

The authors report on their early results in the ultrasound (US) follow-up of postoperative brain pathology, both supra- and infratentorial. The use of US is dependent on the presence of an acoustic window in the skull after craniotomy. Five patients were investigated via a suboccipital craniotomy and one patient via a temporal skull defect. In the patients with a suboccipital craniotomy the greatest part of the posterior fossa, the 3rd and lateral ventricle could be made visible. In a patient with a temporal craniotomy the involved parts of the brain were demonstrated satisfactorily. If a skull defect persists after surgery US may be of value in the follow-up of postoperative conditions, such as the assessment of tumour residue or recurrence, hydrocephalus, postoperative complications and response to radio- or chemotherapy.

Adolescent↗

Comparison of iohexol 300 mg I/ml and Hexabrix 320 mg I/ml in central angiography. A double-blind trial.

Iohexol 300 mg I/ml and Hexabrix 320 mg I/ml have been compared in a randomized, double blind, parallel study, to evaluate hemodynamic parameters, diagnostic information and adverse reactions. A total of 55 patients entered the study, one of them was later excluded, because both contrast media were given by mistake. In the included material, 21 patients were given iohexol 300 mg I/ml in 55 selective injections, and 23 patients Hexabrix 320 mg I/ml in 65 selective injections. The median total dose was 52 (12-88) ml in the iohexol group and 51 (13-118) ml in the Hexabrix group. No changes in heart rate were seen. Angiograms of good or excellent quality were obtained, and no difference between the two media was shown. No serious adverse reaction occurred, and no statistical significant difference was found between the two media with respect to subjective patient reactions. The results indicate that the non-ionic, low-osmotic contrast medium iohexol is well tolerated in cerebral angiography with respect to the parameters tested. No statistical significant difference was found in any of these parameters between iohexol and Hexabrix.

Adult↗

Familial porencephalic white matter disease in two generations.

We report the pedigree of a family in which a mother and her two children, a boy and a girl, all suffer from a similar, though variably expressed cerebral disorder, seen on CT as uni- or bilateral cavities within the supratentorial white matter in communication with the ventricular system. Additional white matter hypodensity around the lateral ventricles without ventricular widening provides preliminary evidence of a primary disease of myelination, in the absence of histopathological confirmation. This is probably the first report of "porencephaly" which shows a pattern of autosomal dominant inheritance.

Adult↗

Congenital multiple angiomatosis with brain involvement.

A case of congenital multiple angiomatosis with cerebral involvement is presented. Postmortem investigation showed identical angiomas on skin and brain. The cerebral vascular tumor has caused altered vascularization of the hemisphere, resulting in a development arrest of the corpus callosum and a fetal appearance of the parietal and temporal vessels.

Agenesis of Corpus Callosum↗

[Brain atrophy as an artifact in ACTH administration].

An 8-month-old infant was treated for infantile spasms with long acting corticotrophin 25 IU daily for 32 days. CT, done 2 weeks after the treatment was discontinued, suggested diffuse brain atrophy. Repeat CT one year later was only borderline abnormal. No shift in the skull circumference curve was noted. Comparison to the literature led to the conclusion that the reversible changes in CT were caused by ACTH. The nature of this phenomenon is discussed as well as the implications for CT-diagnosis. The question arises whether ACTH or corticosteroids might cause irreversible brain damage.

Adrenocorticotropic Hormone↗

Unilateral delayed opercularization in a case of Sotos' syndrome (Cerebral Gigantism).

A case of Sotos' syndrome (cerebral gigantism) is described. Pneumencephalography, performed at the age of 15 days, revealed abnormal separation of the opercula on the right. By comparing the contours with developmental anatomical features of this area it agreed with a foetal development of 24 weeks gestational age. Bilateral carotid angiography was normal. CT showed normal development of the Sylvian area at the age of 27 months.

Brain↗

The Joubert syndrome associated with bilateral chorioretinal coloboma.

A case of the Joubert Syndrome is reported. This syndrome, of which 11 cases have hitherto been described, is characterized by aplasia of the cerebellar vermis in addition to episodic hyperpnoea, abnormal eye movements, rhythmic protrusion of the tongue, ataxia, and mental retardation. The diagnosis was made by the clinical symptoms, computerized axial tomography of the brain, and lumbar pneumencephalography. Bilateral typical colobomata of retina and choroid were an additional anomaly, described for the first time in association with the Joubert Syndrome. The possible relationship between the ocular and cerebral anomalies is discussed.

Ataxia↗

Subdural hygroma: results of treatment by ventriculo-abdominal shunt.

Subdural hygromas, which differ from acute and chronic subdural haematomas in clinical features and pathogenetic mechanism, can occur as isolated lesions or in association with ventricular dilatation and/or subarachnoid cysts which are mistaken for atrophy. On the basis of the postulate that these fluid accumulations might be related to a disturbance in CSF circulation, we treated them by ventriculoperitoneal CSF drainage. This was regarded as indicated only for children with symptoms of retardation and a distended ventricular system. Disappearance of the hygroma or the cortical cysts and ventricular dilatation was demonstrated in 9 of 14 children treated by ventriculo-abdominal shunt and in 4 of 7 less seriously affected untreated children. Clinical improvement came later than neuroradiological improvement, and was incomplete in a number of children. Although there are anamnestic factors with an unfavourable effect on development, the hygromas per se can cause cerebral dysfunction which is associated with their bifrontal localization. The principal symptoms are those of retardation in the development of verbal expression, leg motor function and manipulation.

Arachnoid↗

Angiography with metrizamide in neuroradiological examinations.

A summary is given of the results of vascular studies with metrizamide (Amipaque) in four territories: four-vessel studies in children under 1 year of age, vertebral angiography in adults at risk, spinal angiography and superselective studies in the external carotid territory. A comparison is made with the results obtained with meglumine iothalamate and meglumine ioxithalamate.

Adolescent↗

Organoid nevus syndrome (linear nevus sebaceus of Jadassohn): clinical and radiological study of a case.

A 3 1/2-year-old boy with this syndrome is reported. The clinical features were: linear organoid nevus, characteristically involving the midline of the face with extension to one side (right side in this case), hemimacrocephaly, mental and motor retardation, epilepsy originating from a focus in the right hemisphere, a malformed hemisphere and ventricular system on the right side on pneumoencephalographic and angiographic study and a hamartoma-like malformation protruding into the frontal horn of the right lateral ventricle.

Cerebral Angiography↗

Thoracic myelography with metrizamide.

A description is given of the technique used in thoracic myelography with metrizamide (Amipaque). Analysis of 60 cases demonstrates the results that were obtained.

Humans↗