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Biomedical subjects

J Vague

Publications and source records attributed to J Vague.

At least 19 recordsLinked to original sources
PubMed1989

[Sexual differentiation of the adipose tissue-muscle ratio. Its metabolic impact].

Muscle and fat development are regulated by opposite and also cooperating factors. Adipo-muscular ratio is the result of those forces. The need of a determined fat mass and of its corollary a determined muscle mass is an important physiologic parameter. Sexual differentiation is the main factor adipo-muscular ratio. Feminine fat is twice as big as masculine fat: it predominates in the lower body, masculine fat in the upper body. Brachio-femoral adipo-muscular ratio is, among others, a good index of fat sexual differentiation. Android obesity, predominating in both sexes in the upper body, is, with genetic predispositions, the main factor of non insulin dependent diabetes carbohydrate sensitive hyperlipoproteinemia, hyperuricemia, atherosclerosis. Easy determination on fat topography before the age of 30 is, particularly in women, the best tool for an efficacious prophylaxis of obesity's metabolic complications.

Adipose Tissue↗
PubMed1983

[Comparative study of adrenaline-induced lipolysis of human deltoid and trochanter adipose tissue].

In vitro lipolysis by adrenaline, adrenaline + phentolamine (alpha-blocker) and isoprenalin (beta-agonist) was studied in deltoid and trochanter adipose tissues of sixteen obese females (10 android and 6 gynoid). Lipolysis differs in the upper and lower parts of the body. The more the obesity predominates in the upper part of the body, the more this difference is significant. If the actions of adrenaline in gynoid obese women are identical in deltoid and trochanter adipose tissues, the alpha-antilipolytic effect is more powerful than the beta-antilipolytic effect on the trochanter adipose tissue of android obese women.

Adipose Tissue↗
PubMed1983

[Hormones and aging. 2].

The main hormonal disturbances in ageing are: 1) a slight decrease in the secretion of all hormones, with the exception of gonadotropins in women whose production increases sharply as a result of the almost complete suppression of ovarian activity; 2) a slight but substantial resistance of tissues to the action of most hormones; 3) the cessation of estrogen secretion with an important decrease in androgen secretion in the ovaries; 4) a decrease in androgen secretion with a lesser reduction in estrogen secretion in the testicles; 5) an important decrease in adrenal androgen secretion in both sexes. These findings are the consequence and not the cause of ageing which, to some degree, they do promote, especially in bone, muscle, skin and mucous membranes. Therapeutic incidences of the hormonal disturbances in ageing, though not negligeable, are still limited.

Adrenal Cortex↗
PubMed1983

Testicular feminization syndrome. An experimental model for the study of hormone action on sexual behavior.

Truly feminine consciousness of gender identity, normal extragenital erotogenic sensitivity, suppressed or very reduced clitoris sensitivity and reaction, normal reaction of the labia minora and the vagina which deepens with the renewal of intercourse, realization of pleasure climax without clonicotonic orgasm and followed by resolution, and a normal maternal attitude seem to characterize sexual behavior in a complete or almost complete testicular feminization syndrome. These features allow one to clearly distinguish, without ignoring multiple psychologic mechanisms, the factors related to androgens and to estrogens in normal feminine sexual behavior.

Adult↗
PubMed1983

Clinical features of diabetogenic and atherogenic obesity.

Fat mass per se has little effect on the progression of obesity towards diabetes. Predominance of fat in the upper part of the body resulting in android obesity is at least the clinical reflection of factors which lead obesity to progress towards diabetes and atherosclerosis. Therefore, this type of obesity may be termed diabetogenic and atherogenic obesity. Insulin and cortisol secretion in obesity are not correlated with body fat but with the predominance of fat in the upper part of the body. Diabetogenic obesity may evolve through 5 stages from initial obesity without diabetes to insulin dependent diabetes in previously obese subjects. Aside from the characteristics of body fat distribution, the mechanisms which induce or interrupt this progression remain unknown.

Adolescent↗
PubMed1982

[Hormones and aging, (1)].

The main hormonal disturbances in ageing are: a slight decrease in the secretion of all hormones, with the exception of gonadotropins in women whose production increases sharply as a result of the almost complete suppression of ovarian activity; a slight but substantial resistance of tissues to the action of most hormones; the cessation of estrogen secretion with an important decrease in androgen secretion in the ovaries; a decrease in androgen secretion with a lesser reduction in estrogen secretion in the testicles; an important decrease in adrenal androgen secretion in both sexes. These findings are the consequence and not the cause of ageing which, to some degree, they do promote, especially in bone, muscle, skin and mucous membranes. Therapeutic incidences of the hormonal disturbances in ageing, though not negligible, are still limited.

Aged↗