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Biomedical subjects

J Traeger

Publications and source records attributed to J Traeger.

At least 109 records · Page 6Linked to original sources
PubMed1982

Kinetics of a high dose of piretanide in renal failure.

The kinetics of piretanide was studied in patients with renal failure. After oral administration of a high dose of piretanide (96 mg), the pharmacokinetic parameters were: elimination rate constant 0.346 +/- 0.072 h-1, half life 2.00 +/- 0.35 h, and total plasma clearance 119.55 +/- 35.90 ml x min-1. Compared to the values obtained in adults with normal renal function, these results show a decrease in total plasma clearance, but conservation of the metabolic clearance which amounts to 45% of the total clearance in the healthy adult.

Administration, Oral↗
PubMed1982

Instability of beta E-messenger RNA during erythroid cell maturation in hemoglobin E homozygotes.

Hemoglobin E interacts with beta-thalassemia to produce a disorder of variable severity that is the most common form of symptomatic thalassemia in Southeast Asia. The beta E-globin gene acts as a mild thalassemia gene; there are low levels of beta E-messenger RNA (mRNA) in reticulocytes, and preliminary evidence had suggested that this might be due to instability of the beta E-mRNA. Analysis of beta E-mRNA levels in the nuclei and cytoplasm of bone marrow erythroblasts compared with reticulocytes has shown higher levels of beta E-mRNA in the former, providing direct evidence that this is the case.

Bone Marrow↗
PubMed1982

Clinical experience with renal and neoprene-injected segmental pancreatic allografts in man.

We describe 22 clinical cases of segmental pancreatic grafts that were prepared with neoprene injection in the pancreatic duct. Complete correction of the diabetes is obtained during the period of function of the graft. The surgical procedure is a safe one and does not lead to a higher surgical risk than the usual kidney transplantation. Progress should be made by early detection and effective treatment of the pancreatic graft rejection. Corticoids should be avoided to suppress the diabetogenic effect. Cyclosporine A will probably be the immunosuppressive of choice.

Adolescent↗
PubMed1982

New method for the specific clearance of antibodies using antigens linked to a collagen film.

A new type of immunoadsorbent, derived from a commercial haemodialysis module, has been designed. The dialysis membranes were replaced by bovine collagen membranes on which a given antigen had been linked by covalent binding. First, these membranes were tested in vitro: they were placed in contact with a given volume and concentration of antiserum to define their capacity to retain antibodies. Second, they were stacked in a modified haemodialyzer for antibody extraction ex vivo in dogs: the blood of immunized animals was passed over the immunoadsorbent and recirculated after either partial or total removal of antibodies. The degree of purification is related to the area of the membranes used and to the volume of blood to be purified.

Animals↗
PubMed1981

Cystine crystalluria and urinary saturation in cystine and non-cystine stone formers.

It has been suggested recently that the first step in the formation of calcium oxalate stones appears to be crystallisation. This step is said to depend on the state of saturation of the urine. This hypothesis was checked in cystine stone formers. Cystine crystalluria was found in 83% of 24 urine samples from cystine stone formers (CSF) but in one of the 400 control samples and appears to be a good guide in the diagnosis of cystine lithiasis. Urinary cystine saturation was constantly higher in CSF than in non-cystine stone formers (NCSF) who exhibited undersaturated urine with respect to cystine. There was almost no overlap between these 2 groups. Crystals were never found in undersaturated urine and were always present when the saturation was above 1. There appears to be a good correlation between the level of urinary saturation and the presence of crystalluria and there is no need for any additional factor such as a defective inhibitor. The study underlines the limits of a therapeutic regimen of a high fluid intake and alkalinisation of the urine.

Crystallization↗
PubMed1981

Acute effect of high dose (48 mg) of piretanide in advanced renal insufficiency.

1 The acute effects of a high dose of piretanide, a new potent diuretic were studied in eight patients with severely impaired renal function (GFR between 0.09 and 0.17 ml s-1 1.73 m-2). 2 After hydration and following two control periods, a single dose of 48 mg piretanide was ingested. Thereafter, urine was collected every 30 min for 2 h and every hour for the next 4 h. Urinary fluid losses were replaced orally (100 ml of water ever hour) and intravenously (isotonic saline + glucose infusion). 3 The following measurements were made: urine flow rate, clearances of inulin, PAH, urea, creatinine, uric acid, osmolar and free water clearances, excretion rates of sodium, chloride, potassium, calcium, phosphate, bicarbonate, ammonium, titratable acidity and urine pH. 4 Piretanide (48 mg) appeared to be effective in advanced renal insufficiency, producing a significant increase in urine flow rate, in sodium, chloride, potassium and calcium excretion and in Cosm. 5 There was no significant change in GFR, as measured by inulin clearance, or in the other measured parameters.

Adult↗
PubMed1981

Fractions of middle molecular weight responsible for immunodeficiency in malnourished and burnt patients.

Patients with protein calorie malnutrition (PCM) or burn injury have a high incidence of infection, partly related to a secondary deficiency of cell-mediated immunity. We have studied sera from 37 patients with PCM, 19 burns patients, and 8 uremic patients, and results were compared with those obtained in 12 healthy individuals. Chromatography on Sephadex G-25 fine revealed a high peak of so-called Middle Molecules. This fraction appeared to be almost superimposable on that separated from sera and urines of uremic patients, but even more concentrated especially in burns patients and in the severely hypoproteinemic patients with kwashiorkor. The proliferative responses of normal lymphocytes were inhibited by the patients' sera. A significantly more potent inhibition was obtained with middle molecular weight fractions from sera of these patients. Percentages of mixed lymphocyte reaction (MLR) inhibition were 69.38 +/- 21.69 (eluates from PCM patients), 67.05 +/- 21.75 (eluates from burnt patients), 66.37 +/- 31.38 (eluates from uremic patients), and 26.00 +/- 18.90 (eluates from control sera). Indirect evidence suggests that these inhibitory fractions may be responsible for several of the immunologic and hematologic disturbances found in PCM and in burnt patients.

Adult↗
PubMed1981

Effect of middle molecules on immunological functions.

The cell-mediated immunodeficiency secondary to renal failure is well established and is largely dependent on toxic or inhibitory serum factors. Our approach was to investigate the effect of so-called middle molecules (MM) on in vitro and in vivo immunological functions. A crude fraction of MM isolated from the serum or urines of uremic patients by chromatography on Sephadex G-25 fine was shown to markedly inhibit the lymphocyte proliferation induced in vitro by various phytomitogens or by allogeneic cells. A marked depression of the graft-versus-host reaction was demonstrated in vivo. When rats were continuously infused with MM, a significant delay of skin allograft rejection was obtained. From these results it is clear that the MM fraction contains a potent inhibitor of several T lymphocyte functions.

Animals↗