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Biomedical subjects

J Traeger

Publications and source records attributed to J Traeger.

At least 91 records · Page 5Linked to original sources
PubMed1984

[Diagnosis of relative hypomagnesurea in calcium lithiasis: reference values for a new parameter].

In calcium stone formers, the ratio of urinary magnesium concentration to urinary calcium concentration (Mg/Ca) is used to express the already reported low Mg excretion relatively to Ca excretion. However the Mg/Ca value depends on the Ca excretion rate, decreases after oral Ca load and is not directly related to Mg excretion. Therefore when studying patients with different Ca excretion rates, or when performing an oral Ca load, Mg/Ca is not directly useful to express a relative hypomagnesuria. We established a new parameter from the normal relationship between urinary Mg and Ca excretion rates. Its value is above - .065 in 97.5% of 99 control urinary samples. It is stable for any studied Ca excretion rate, including post Ca load excretion rates, and is highly correlated with Mg excretion rate. This parameter allows for the accurate diagnosis of relative hypomagnesuria in stone formers.

Adult↗
PubMed1983

Pathology of the pancreas after intraductal neoprene injection in dogs and diabetic patients treated by pancreatic transplantation.

The injection of neoprene into the pancreatic ducts of dogs has been used to destroy exocrine function prior to pancreatic transplantation. The subsequent histological changes and the evolution of lesions over a period of 3-36 months are described. Animals were sacrificed or biopsied at various intervals (3, 15 and 36 months) and the pancreases showed the disappearance of exocrine acini and changes of chronic pancreatitis. An immunoperoxidase procedure with insulin, glucagon, somatostatin and pancreatic polypeptide antisera was used to show the persistence of pancreatic endocrine cells. After the injections, sclerosis progressively increased and secondary lesions of the islets were seen, although functional islets persisted. This technique was then applied to pancreas transplantation in man. Eight transplants from seven diabetic patients were available for examination. In four cases, there were early technical failures, but four pancreatic transplants continued to function for 28-889 days until suppuration destroyed one of the grafts and the three other patients died. The persistence of endocrine cells in sclerotic tissue was observed in histological and immunopathological examinations.

Adult↗
PubMed1983

The hyperactive halo as a sign of renal graft death in 99mTc-DTPA studies.

In scintigraphic studies of renal transplants the absence of renal perfusion and clearance have been demonstrated to have many possible pathologic etiologies, vascular obstructions, and rejections. Increased perinephric activity was suggested as a sign of renal infarction and its absence may indicate potential renal viability. A case is presented in which a hyperactive halo was seen when the graft was dying.

Female↗
PubMed1983

Endocrine responses of type 1 (insulin-dependent) diabetic patients following successful pancreas transplantation.

The aim of the present study was to evaluate the insulin and glucagon responses to various stimuli in patients following pancreatic transplantation. Four Type 1 (insulin-dependent) diabetic patients with end-stage renal failure who had received a cadaveric segmental, neoprene-injected, pancreas transplant, in association with kidney transplantation, were investigated. Free-insulin, pancreatic glucagon, and growth hormone concentrations were measured after both oral and intravenous glucose tolerance tests, and following tolbutamide, arginine and arginine plus somatostatin infusions. Tests were performed 1 month (three cases) and 30 months (one case) after surgery, when no insulin administration was required. Four non-diabetic kidney grafted patients, matched for duration of graft survival and immunosuppressive treatment (steroids, azathioprine and anti-lymphocyte-globulins), served as control subjects. Impaired glucose tolerance was present in all diabetic and control patients. This was possibly related to immunosuppressive treatment. In comparison with control subjects, insulin release was normal in response to arginine and tolbutamide but was reduced in response to oral and intravenous glucose, while glucagon and growth hormone release were similar in both groups. Somatostatin was less effective in diabetic patients than in control subjects in suppressing insulin and glucagon release.

Adult↗
PubMed1983

Pharmacokinetics of diltiazem in severe renal failure.

The acute effects of a single dose of diltiazem (Tildiem), a calcium antagonist, were studied in 9 patients with severely impaired renal function (GFR between 0.03 and 0.87 ml/s/1.73 m2). Control measurements were made of inulin and PAH clearance, creatinine, blood pressure, heart rate and ECG. Following administration of diltiazem 120 mg, 7 blood samples were collected in the first 12 h and after 24 h, 32 h, 48 h; urine was collected for the first 12 h, 12-24 h and 24-48 h, and blood pressure, heart rate and ECG were recorded after 6 h. Diltiazem and its main metabolite, desacetyldiltiazem, had a pharmacokinetic profile similar to that in patients with normal renal function (peak plasma concentration, half-life and urinary excretion). Diltiazem is normally eliminated in the urine to a small extent, because it is metabolized, and this also applies to desacetyldiltiazem, which is probably further metabolized.

Adult↗
PubMed1983

A method for early detection of graft failure in pancreas transplantation.

Pancreatic transplantation is intended to normalize carbohydrate metabolism in insulin-dependent diabetics by restoring endogenous insulin release, and it is usually performed together with kidney transplantation in patients with end-stage renal failure. A major problem in these patients is the daily control of the grafted pancreas because traditional measurements do not appear to be adequate to evaluate pancreatic function. Aiming at early detection of graft failure, we have analyzed in 8 such patients and in 20 nondiabetic kidney-grafted patients (a control group) the following variables: 24-hr glycosuria (absolute values, or values after natural logarithmic transformation) and 24-hr urinary C-peptide excretion (corrected for 24-hr urinary creatinine). These measurements, considered alone, did not detect pancreatic graft failure; for instance, glycosuria can depend on immunosuppressive steroid treatment, and it was often found even in the control group. On the contrary, the ratio Ln 24-hr glycosuria: 24-hr urinary C-peptide varied from 0.00 to 0.18 in the control group and in normally working pancreatic grafts; when the pancreatic grafts failed, however, as confirmed by arteriographic evidence, histologic findings, or dynamic endocrine tests, this ratio rose far higher than 0.18, reaching values as high as 12.2. Use of this ratio provides a simple technique for daily evaluation of pancreatic graft function and for early detection of graft failure.

Diabetes Mellitus↗
PubMed1983

Spontaneous remission of severe hyperparathyroidism in chronic renal failure.

The sudden onset of hypocalcemia occurring in a patient undergoing hemodialysis led to the diagnosis of spontaneous remission of severe hyperparathyroidism. This was confirmed by a marked reduction in immunoreactive parathyroid hormone level. The hypocalcemia was controlled by 1,25-dihydroxycholecalciferol. A dramatic improvement of hyperparathyroid bone disease, as assessed by radiographic and histomorphometric examination, was observed.

Adult↗
PubMed1983

Absence of complement activation in vitro by sodium meglumine ioxitalamate.

The effect of radiographic contrast media on proteins of the complement system in vitro was investigated using protein level measurement and crossed immunoelectrophoresis. Despite the 20% loss of total serum hemolytic activity (CH50) induced by sodium meglumine ioxitalamate (0.5 M), no significant changes in C3c, C3N or B were detected by radial immunodiffusion. These contrast media did not cause electrophoretic conversion of C3, as assessed by the absence of split product, and the small degree of spontaneous C3 conversion (loss of 20% C3N antigen and the presence of two peaks with C3c antigen) which occurred when serum was incubated in polypropylene tubes, was inhibited by the contrast media. The effects of sodium meglumine ioxitalamate and zymosan in vitro on complement activation were compared.

Blood Proteins↗
PubMed1983

Improvement of cadaveric renal allograft survival by thoracic duct drainage: relation with T-lymphocyte subset modifications assessed by flow-cytometry.

Thoracic duct drainage (TDD) with reinfusion of cell-free lymph was performed in 118 prospective recipients within four months before transplantation. TDD was unsuccessful in 27 patients (A); it yielded 1-19 X 10(9) lymphocytes in 25 cases (B) and 20-185 X -10(9) in 66 cases (C). The incidence of acute rejection episodes and the requirement for early post-transplant dialysis were lower in C than in A. Six patients were studied for T-lymphocyte subsets, using monoclonal antibodies from OKT series and a monomorphic and HLA-DR (BL2) raised in our laboratory. During TDD peripheral blood lymphocyte (PBL) counts decreased and the percentage of BL2 cells increased. Simultaneously, typical small PBL were replaced by large less differentiated cells slightly labelled by OKT3, some of them bearing both OKT4 and OKT8 markers. The larger the depletion, the earlier the emergence of immature T-cells. In lymph fluid, lymphocyte counts decreased later than in blood, the proportion of T8+ cells lacking Fc receptors increased with time. Changes in B patients were less than in C. These results support the hypothesis that T-cell subset modifications represent the main immunological change accounting for better allograft prognosis.

Antibodies, Monoclonal↗
PubMed1983

Progress in segmental neoprene-injected pancreas transplantation. Advantages and disadvantages of using Cyclosporin A.

We performed 39 neoprene-injected pancreatic transplants (38 segmental and 1 total) in 37 insulin-dependent diabetic recipients from October 1976 to May 1983. The best results were obtained when the pancreas was transplanted simultaneously with the kidney (25 cases). The use of Cyclosporin A (CyA) for immunosuppression did not reduce the early pancreatic failures, but it seems to have slightly improved the long-term survival. The glycaemic control was better in patients treated by CyA alone than in those receiving steroids. The main side effects of CyA were nephrotoxicity and some immunoglobulin abnormalities with or without lymphoproliferative disorders occurring after treatment with CyA and ALG.

Adult↗