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J T Manning

Publications and source records attributed to J T Manning.

98 records · Page 6Linked to original sources
PubMedDate not supplied

Philadelphia chromosome without breakpoint cluster region rearrangement in a case of Lennert's lymphoma of suppressor phenotype.

A 60-year-old woman presented with diffuse lymphadenopathy. Diagnostic and staging work-up showed that the patient had diffuse small cleaved cell lymphoma (diffuse poorly differentiated lymphocytic lymphoma) with associated histiocytes (lymphoepithelioid cell lymphoma) by the Kiel classification system. Immunohistologic staining showed a T suppressor cell tumour phenotype. Cytogenetic studies revealed the Philadelphia chromosome (Ph1). On DNA studies, the breakpoint cluster region (BCR) gene was not rearranged suggesting that the Ph1 involvement was not identical to that seen in chronic myelogenous leukemia (CML). This case is presented because of the rarity of Ph1 in lymphoid malignancies, particularly in those of T-cell origin, and because of its potentially adverse implications.

Antigens, Differentiation, T-Lymphocyte↗
PubMedDate not supplied

Retroperitoneal granular cell tumor. Computed tomography findings with 5-year follow-up.

We describe the computed tomography (CT) appearance of an unusual, large retroperitoneal granular cell tumor and provide a 5-year follow-up. The tumor occurred in association with multiple, smaller, subcutaneous granular cell tumors. The CT findings were nonspecific, but the scans delineated the extent of the lesion and its relationship to adjacent vessels well. To our knowledge, this report is the first description of the CT appearance of retroperitoneal granular cell tumor in the medical literature.

Adult↗
PubMedDate not supplied

Second to fourth digit ratio, body mass index, waist-to-hip ratio, and waist-to-chest ratio: their relationships in heterosexual men and women.

BACKGROUND: Prenatal sex steroids have been broadly discussed in terms of their possible effect on brain differentiation, whereas pubertal/adult sex hormones are thought to be the main regulators of sexually dimorphic physical features in males and females. Assessing prenatal steroid exposure has previously been difficult but evidence now suggests that finger length ratio may provide a 'window' into prenatal hormone exposure. The length of the second digit (the index finger) relative to the length of the fourth digit (the ring finger) is sexually dimorphic as males have a lower second to fourth digit ratio (2D:4D). The sexual dimorphism is determined as early as the 14th week of fetal life, and remains unchanged at puberty. There is evidence that sex differences in 2D:4D arise from in utero concentrations of sex steroids, with a low 2D:4D (male typical ratio) being positively related to prenatal testosterone, while a high 2D:4D (female typical ratio) is positively associated with prenatal oestrogen. AIM: The studied aimed to determine whether, and to what extent, adult sexually dimorphic physical traits, which are largely determined at puberty, relate to traits that are largely determined in utero. This work examined the relationship between three sexually dimorphic traits--body mass index (BMI), waist-to-hip ratio (WHR) and waist-to-chest ratio (WCR)--and digit ratio. PARTICIPANTS AND METHODS: BMI, WHR and WCR were assessed in 30 heterosexual male and 50 heterosexual female participants by recording their body height, weight, and measuring their waist, hip and chest circumference. Digit lengths of the second and fourth fingers were measured from photocopies of the ventral surface of the hand and by actual finger measurements. RESULTS: Digit ratio was found to be significantly lower in men than in women. Significant negative correlations were found between female's left and right hand 2D:4D, waist and hip circumference, and WCR. In males, BMI was found to be positively related to digit ratio but remained significant only for left hand 2D:4D. Generally, the relationships were stronger for females than for males. Although not all relationships were found to be significant, they were in accord with our predictions. CONCLUSION: In addition to an activational effect of sex hormones at puberty, the present data suggest an early organizational effect of sex hormones through the association between indices of female body shape, male BMI, and human finger length patterns.

Adult↗
PubMedDate not supplied

Second to fourth digit ratio: ethnic differences and family size in English, Indian and South African populations.

BACKGROUND: The second to fourth digit ratio (2D:4D) is lower in men than in women. 2D:4D may be established in utero and is negatively correlated with sperm counts and testosterone in men and positively correlated with oestrogen in men and women. Negative associations between male 2D:4D and family size and positive associations between female 2D:4D and family size have been found in some European populations. AIM: The study seeks to investigate the relationship between 2D:4D and family size in samples from Europe, Asia and Africa. SUBJECTS AND METHODS: Measurements of right hand 2D:4D were made in English (Merseyside, n = 403), Indian (Sugali and Yanadi, n= 160) and South African (Zulu,n = 258) populations. RESULTS: 2D:4D was weakly sexually dimorphic and showed strong ethnic differences. There were significant associations between 2D:4D and family size. For males these included negative associations in English and South African samples, and in the total sample. In females there was a positive association in the English sample, a negative association in the South African sample, and the total female sample showed a positive relationship between 2D:4D and family size. CONCLUSIONS: 2D:4D showed weak sex and strong ethnic differences. Low values of 2D:4D were associated with large family size in men. The situation was less clear in women but on balance there was evidence to support a relationship between high values of 2D:4D and large family size.

Adult↗
PubMedDate not supplied

Malignant rhabdoid tumor.

Immunocytochemistry and electron microscopy have allowed more precise identification and classification of neoplasms formerly considered as representatives of other groups. The malignant rhabdoid tumor is one example. Principally neoplasms of the kidney, rhabdoid tumors present uncommonly in the head and neck, where because of the age of the patients and the neoplasms' resemblance to rhabdomyosarcoma, misdiagnosis is possible and likely. Wherever it arises, the lesion is usually fatal.

Child, Preschool↗