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J T Goodrich

Publications and source records attributed to J T Goodrich.

At least 37 records · Page 2Linked to original sources
PubMed1996

Mesenchymal chondrosarcoma in anterior skull base: case report.

We report the case of a 16-year-old boy who presented with mesenchymal chondrosarcoma involving the ethmoid sinus, right orbit, nasal cavity, and anterior cranial fossa. The tumor was totally resected by craniofacial surgery; the patient's postoperative course was uneventful. Microscopically, the tumor was composed of highly cellular undifferentiated small cells, alternating with zones of cartilaginous tissues. Mesenchymal chondrosarcoma is a rare, aggressive variant of chondrosarcoma, which might be encountered more frequently due to the advances in neuroimaging and surgical procedures.

Adolescent↗
PubMed1995

Mesenchymal chondrosarcoma with secondary orbital invasion.

Orbital involvement with mesenchymal chondrosarcoma is rare. Until recently, despite the young age of the affected population, exenteration was the recommended management. We report a patient with orbital invasion by mesenchymal chondrosarcoma managed surgically without exenteration. Adjuvant chemotherapy and radiotherapy were administered. There is no evidence of local or distant tumor recurrence with 30 months of postoperative follow-up. This and other recent case reports suggest that exenteration may not be necessary for local tumor control of mesenchymal chondrosarcoma in the orbit.

Adolescent↗
PubMed1994

Silicone allergy in ventriculoperitoneal shunts.

Reported are the cases of three hydrocephalic patients who developed a clinically heterogenous entity with an allergic rejection of their silicone ventriculoperitoneal shunts. All of the patients had an original presentation indicative of a shunt infection, but laboratory analysis revealed sterile cerebrospinal fluid in all three cases. The typical course included recurrent skin breakdowns over the shunt tract, subsequent infections and development of fungating granulomas. Treatment, with successful resolution of the symptoms, included changing the shunt material from silicone to polyurethane, with immunosuppression in one patient and removal of the shunt altogether in the other two patients. The roles of the immune system and silicone in the pathophysiology of this condition are discussed.

Adolescent↗
PubMed1994

Asterion region synostosis.

Posterior plagiocephaly historically has been associated with synostosis of the lambdoid suture. The incidence, diagnosis, and modes of treatment for stenosis of the lambdoid suture remain controversial. Commonly, the lambdoid suture is found to be open both on radiographic examination and at the time of surgery. The study reports on nine patients who presented with unilateral posterior plagiocephaly and who were found to have open lambdoid sutures, but a stenosed region of the asterion. The area of involvement included the distal-most lambdoid suture, the parietomastoid, occipitomastoid, and proximal squamosal sutures. Positional molding or torticollis was ruled out in all patients. All the patients showed progressive involvement of the skull base, including anterior shifts of the ipsilateral ear, compensatory ipsilateral frontal bossing and malar protrusion. Stenosis of the asterion was diagnosed with three-dimensional computed tomography scans, corroborated at the time of surgery and confirmed histologically. Surgical correction involved resection of the affected asterion and reconstruction using a bandeau-technique, barrel staves of the occipital bone and bone graft transposition. This approach provided excellent esthetic results in all patients.

Cranial Sutures↗
PubMed1992

Electrical stimulation and multichannel EMG recording for identification of functional neural tissue during cauda equina surgery.

Electrical stimulation of structures within the surgical field was used to identify functional neural elements during 25 cauda equina operations. EMG responses from anterior thigh, posterior thigh, and anal sphincter muscles were recorded simultaneously using a multichannel signal averager. During nine operations, stimulation of a presumed filum terminale or other tissue produced clear EMG responses, prompting modification of surgical procedures. In one patient, this resulted in preservation of a flattened spinal cord which resembled a band of scar tissue. Some EMG responses were restricted to a single muscle group; these neural structures would probably not have been identified if only a single-channel EMG recording was used. Visual examination alone was not adequate for identifying functional neural elements, or for determining whether atretic-appearing nerve roots were functional. Electrical stimulation with multichannel EMG recording facilitates the preservation of functional neural elements and the optimization of surgical results in cauda equina surgery.

Adolescent↗
PubMed1992

Split-thickness bone grafts in complex craniofacial reconstructions.

We have operated on 20 patients with various forms of complex skull defects due either to trauma, tumor, or craniofacial problems. These cases have required complex reconstruction of defects involving the calvarium and anterior skull base. We review here our techniques of using locally harvested split-thickness calvarium bone grafts in the reconstruction of complex face and anterior fossa defects, secondary to tumor, trauma and craniofacial problems. With these harvesting techniques sufficient bone becomes available for large reconstructions, with minimum morbidity to the patient. The aesthetic results are excellent allowing for good facial and forehead contouring with minimal risk to the patient. In the case of traumatic injuries the surgery can also be performed early with the risk of infection being markedly reduced. Long-term results with split-thickness calvarial grafts have shown less bone resorption when compared with rib grafts.

Abscess↗
PubMed1991

A primary encephalocele culture yields a pure population of human astrocytes.

In order to develop a reliable source of human astrocytes for in vitro studies, we established a primary explant culture of a human encephalocele. This culture yielded a population of cells which were karyotypically normal, morphologically resembled astrocytes, expressed glial fibrillary acid protein, and responded mitogenically to exogenous growth factors. We conclude that white matter derived from human encephaloceles can be used to generate pure populations of normal astrocytes.

Astrocytes↗
PubMed1988

Optic gliomas and neurofibromatosis: neurosurgical management.

Optic nerve gliomas occur in 5-15% of patients with neurofibromatosis; while many tumors are asymptomatic and stable, others cause significant morbidity and mortality. The availability of modern, noninvasive diagnostic modalities allows earlier diagnosis of this tumor, and even permits close observation as an alternative to therapeutic intervention in selected circumstances. Anterior tumors are best treated by observation, followed by surgical excision and radiation therapy if they enlarge and cause significant visual impairment. Posterior tumors are best treated by diagnostic biopsy and possible debulking, followed by radiation therapy. While chemotherapy appears a promising alternative to radiation therapy, insufficient experience has been obtained to draw any firm conclusions on the merit of this modality.

Cranial Nerve Neoplasms↗
PubMed1985

Ciliated craniopharyngioma.

A tumor of Rathke's cleft origin was studied, which showed some histologic features consistent with craniopharyngioma, but also had ciliated and mucin-containing cells more commonly observed in Rathke's cleft cysts. The combination of features provides further evidence that craniopharyngiomas and Rathke's cleft cysts have a common embryonic origin.

Craniopharyngioma↗
PubMed1984

Heterosexual and homosexual patients with the acquired immunodeficiency syndrome. A comparison of surveillance, interview, and laboratory data.

Homosexual and heterosexual patients with the acquired immunodeficiency syndrome were compared by risk group. Race; diagnoses; history of sexually transmitted diseases, sexual behavior, and drug use; and socioeconomic indicators differed considerably among risk groups, suggesting different risk factors for acquisition of the syndrome. Patients in the homosexual, intravenous drug user, and Haitian risk groups differed in their serologic response to cytomegalovirus and syphilis testing, presumably due to lifestyle-related exposures. Differences in the rate of recovery of cytomegalovirus, serum levels of IgA and IgG, and antibody titers to Epstein-Barr virus were noted among patients with different diagnoses. We conclude that in studies of risk factors for the acquired immunodeficiency syndrome, patients should be analyzed by risk group and diagnoses.

Acquired Immunodeficiency Syndrome↗
PubMed1982

How to treat PID.

Explore the source record for details and available documents.

Diagnosis↗
PubMed1980

Phylogeny of enteric serotonergic neurons.

Serotonergic neurons have previously been identified in the enteric nervous systems of humans, subhuman primates, rodents, and rabbits. The distribution of enteric serotonergic neurons in lower vertebrates was examined in order to determine if these neurons are restricted to mammals and, if they are found more generally amongst vertebrates, when they first appear in vertebrate phylogeny. Since mammalian enteric serotonergic neurons take up 3H-serotonin by a highly specific mechanism, the radioautographic demonstration of axonal uptake of 3H-serotonin was used as the primary tool in looking for these neurons. As controls, conditions known to interfere with 3H-serotonin uptake by mammalian enteric neurons were also examined. These controls included incubation with 10 microM fluoxetine, a specific antagonist, incubation in Na+-free medium, and incubation in the presence of a 100-fold excess of nonradioactive serotonin. Radio-autographic labeling had to be absent or greatly reduced under all three control conditions for labeling by 3H-serotonin to be considered specific. Labeled enteric axons were found in cyclostomes (hagfish), teleosts (goldfish), and amphibia (bull-frog) but not in tunicates (sea squirt; sea vase) or echinoderms (sea cucumber). In addition, the serotonin concentration was measured in the intestine of two vertebrates, hagfish and goldfish, that do not have serotonin-containing enterochromaffin cells. Serotonin was found in both; in hagfish, the amine concentration was highest in preparations of muscularis externa containing the myenteric plexus. It is concluded that enteric serotonergic neurons arose early in vertebrate evolution, possibly in an ancestral chordate resembling amphioxus, although probably not in more primitive prevertebrates, and that they are a general feature of the vertebrate bowel.

Animals↗
PubMed1978

Hirschsprung's disease: absence of serotonergic neurons in the aganglionic colon.

The distribution of enteric serotonergic neurons was studied in patients with Hirschsprung's disease. Specimens of bowel obtained at surgery were incubated in vitro with tritiated serotonin (3H-5-HT) in the presence of a high concentration of nonradioactive norepinephrine. Sites of high-affinity 3H-5-HT uptake were visualized by light-microscopic autoradiography. Specimens taken from ganglionic regions of the intestine (distal ileum or colon) showed intense labeling of the neuropil within the myenteric plexus. Silver grains were localized in a pericellular distribution around ganglion cells, but the ganglion cells themselves were relatively free of overlying silver grains. Corresponding regions of aganglionic colon or rectum demonstrated silver grain densities equivalent to background levels. Specific labeling was absent over the large nerve trunks in this region. These results suggest that 5-HT-containing neurons are present in the normal human intestine and that these neurons are absent in the aganglionic segment in Hirshsprung's disease.

Autoradiography↗