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Biomedical subjects

J Svejda

Publications and source records attributed to J Svejda.

At least 37 records · Page 2Linked to original sources
PubMed1985

Secondary tumors in cancer patients after therapy.

Forty-five thousand three hundred thirteen patients treated in our Institute during the period 1949-1982 were retrospectively analyzed in regard to the appearance of secondary tumors after therapy. Eighty-seven (0.19%) tumors were found, 71 (81.6%) being secondary and 16 (18.4%) simultaneous. Fifty-one (71.8%) tumors were lymphoid, 20 (28.1%) nonlymphoid. Thirty-seven (52.1%) tumors appeared after radiotherapy, 13 (18.3%) after chemotherapy alone. Secondary tumors appeared mostly after 6 years. The prevalence of lymphoid secondary tumors may be explained as a compensatory proliferation of surviving cells progressing to neoplasia. Cytostatics and ionizing radiation as both the initiators and the promoters of malignancy, have besides person's susceptibility a triggering function. From these aspects before any treatment is started all possible carcinogenic factors should be taken into consideration and less carcinogenic procedures with keeping up a full effectiveness should be chosen.

Adolescent↗
PubMed1983

Cytologic grading in relation to the clinical stage of the breast cancer.

Cytologic grading which may be performed at the same time as diagnostic cytology seems to be of a value in the pathobiology of the breast cancer. Other methods, such as mammography, termography, xenography, histological grading and some biological markers help to establish biological behavior of the tumor and appropriate treatment approach. In spite of the progress in diagnosis and therapy many problems remain to be clarified. In agreement with VORHERR a progress may be expected only from the development of novel approaches such as diagnosis before systematic spread has occurred or by the availability of efficient chemotherapy to kill all disseminated cancer cells.

Adult↗
PubMed1982

Indication of permanent pacing after acute myocardial infarction complicated by combined intraventricular block.

A total of 63 patients with combined intraventricular block with a 60.3% mortality were found among 725 patients with acute myocardial infarction (AMI) with a 20.5% mortality. 25 patients with combined intraventricular blocks survived the hospitalization period--permanent pacing having been introduced in 11 of them. The mean survival time in them was 21.7 months. There were 3 deaths (27.3%), none of them sudden. The remaining 14 patients without pacing survived for a mean period of 15.9 months, with 7 deaths (50%), four of which could be designed as sudden. The authors conclude that permanent pacing "on demand" is indicated in all patients surviving the hospitalization period after AMI complicated by advanced a-v block and after anterior AMI following an older MI with new bilateral His bundle branch block.

Cardiac Pacing, Artificial↗
PubMed1981

[Regeneration of the thread-like papillae in the rat tongue].

The regeneration capacity of the filiform papillae of the rat tongue was studied after destruction through abrasion in 18 rats after time intervals of 1 1/2 days until 7 months. By abrasion were destroyed the epithelial layer, the tunica propria mucosae and part of the muscle layers. Lightmicroscopic investigation showed formation of new filiform papillae, similar in structure to the normal tissue. Scanning electron microscopic investigation brought further details. It showed clearly that in the regeneration area the newly formed filiform papillae were irregularly distributed and of different shapes. These studies make it clear that newly formed epithelial as well as connective tissue has a generally coded property to form new filiform papillae. No fungiform papillae were ever seen to regenerate. It is concluded that these are higher differentiated organs with no capacity to regenerate.

Animals↗
PubMed1980

Mass screening in cancer: efficacy, problems, principles.

With respect to steady increasing incidence of malignant tumors in Czechoslovakia the oncological program was established with the aim to achieve a gradual dispensarization of all population. The main part of the program is the secondary prevention through oncological examinations to find out early stages of tumors or precancerous lesions. The experimental examinations started in four districts and during two years 111,783 inhabitants from selected groups passed the screening. The examinations were also aimed on hypertension and diabetes. The first results revealed 0.2% new malignancies and 24% preneoplastic lesions. As far as hypertension and diabetes concerns there were 6,204 new cases of hypertension and 2,616 of diabetes. The examinations were supported by centers of clinical oncology created 3 years ago in all district and county hospitals. The task of the centers is not only the early diagnosis of all malignancies but also the application of a suitable therapy. For early diagnosis of some tumors there were established special committees which closely cooperate with the center. These are specially the committees for breast cancer and in some hospitals committees for malignant melanoma. The examinations will be gradually extended to other countries in CSR and in spite of many problems which remain to be solved we hope that all these arrangements will help in the fight against malignant tumors.

Adult↗