Search PubMed⌕ Search

Biomedical subjects

J Suzuki

Publications and source records attributed to J Suzuki.

At least 811 records · Page 45Linked to original sources
PubMed1982

67 Ga-labeled human fibrinogen: a new promising thrombus imaging agent.

Gallium-67 labeled fibrinogen was prepared as a new deep-vein thrombus imaging agent, using deferoxamine (DF) as a bifunctional chelating agent. Excellent physicochemical and biological properties of 67 Ga-DF-fibrinogen were obtained. The isotopic clottability was 85.3%. High stability in vivo as well as in vitro was observed. Studies carried out in rabbits with induced thrombi in the femoral vein showed thrombus to blood radioactivity ration of 11.7, comparable to the value estimated with conventional 131I-fibrinogen 24 h after injection. Remarkable visualization of these thrombi with a scintillation camera provided good evidence for the selective mechanism of this new radiopharmaceutical.

Animals↗
PubMed1982

The effect of prostacyclin on cerebral vasospasm. An experimental study.

Prostacyclin (PGI2), a strong vasodilator of cerebral vessels and potent inhibitor of platelet aggregation, was infused intravenously into seven cats after induction of prolonged vasospasm by hourly application of oxyhaemoglobin solution into the subarachnoid space round the basilar artery. PGI2, at a concentration of 50 ng/kg/min, was effective in releasing the vasospasm in the seven cats. It did not produce significant hypotension. This report gives our results and the probable mechanism of action of PGI2 in cerebral vasospasm.

Animals↗
PubMed1982

A new therapeutic method for acute brain infarction: revascularization following the administration of mannitol and perfluorochemicals--a preliminary report.

Ten patients were treated with systemic administration of mannitol followed by blood substitute (perfluorochemicals) in the acute period of cerebral infarction in order to suppress the development of infarction and progressive deterioration. This chemotherapy was followed by reconstructive vascular surgery. There were 8 patients with cerebral infarction and 2 others in whom cerebral vascular occlusion occurred during an operation. Due to this treatment, there was no case in which the patient's condition was aggravated or in which death occurred. At examination two months later, 8 of the 10 patients had returned to productive lives. We consequently believe that this therapeutic method may prove to be an effective means of treating cerebral infarction in the acute stage. It is also thought that this method is applicable in surgical cases in which long-term vascular occlusion is required.

Adult↗
PubMed1982

Surgical treatment of intracranial arteriovenous malformation.

The surgical indication and techniques of intracranial arteriovenous malformations are discussed, on the basis of 203 experiences with AVMs. A special key point in our surgical techniques is described as follows. The feeding arteries of the AVM--or the main artery at the base of the brain, which is the original source of the feeding artery--are identified and prepared, and then temporary clips are placed on these arteries to produce vascular occlusion prior to the dissection of the AVM itself. During these procedures, 20% of mannitol should be administered to prolong the permissible time of cerebral artery occlusion. The administration method of mannitol is described in detail including dose and time schedule. The new prolongation method of temporary occlusion time, for which mannitol with fluorochemicals permits longer occlusion time, is also introduced.

Cerebral Angiography↗