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Biomedical subjects

J Suzuki

Publications and source records attributed to J Suzuki.

At least 793 records · Page 44Linked to original sources
PubMed1983

[Multiple brain tumors with von Recklinghausen's disease].

Thirty-three cases of von Recklinghausen's disease, nine of which had multiple brain tumors, were experienced in our clinic. In this report, these nine cases were reported and discussed, especially representative two cases in detail. Nine cases had various combinations of multiple brain tumors: bilateral acoustic neurinomas in two cases, multiple neurinomas in two cases, multiple meningiomas in one case and multiple neurinomas and meningiomas in two cases. In two cases, multiple brain tumors were totally extirpated at one stage, but both died within ten months. In three cases, partial extirpation of multiple brain tumors were performed at one stage, one died thirteen years after the operation and two are alive but dependent on their families. In recent two cases, two stage operations were performed, by which tumors were successfully removed totally. These postoperative courses were good. The other two cases were treated conservatively. One is alive and working, but has severe auditory disturbance. The other died after six years from onset. Autopsy was performed in this case, which revealed multiple neurinomas in the left 3rd and bilateral 5-12th cranial nerves and numerous meningiomas. In the review of the cases with more than three brain tumors in von Recklinghausen's disease were discussed.

Adult↗
PubMed1983

[Hemodynamics in hemorrhagic infarction--an experimental study].

Using our previously reported "thalamic infarction model in the dogs", it was found that hemorrhagic infarction can be produced at a high frequency following recirculation after 6-12 hours of vascular occlusion. In the present study, in order to elucidate the pathophysiology of hemorrhagic infarction, we have undertaken a study of the relations among the histological findings, degree of ischemia, circulatory dynamics, CO2 response and EEG findings after vascular occlusion of 6 hours. In all animals where rCBF was found to fall to less than 50% due to vascular occlusion, hemorrhagic infarction was found. The hemodynamics of those animals presenting hemorrhagic infarction was such that reflow resulted in a transient increase in rCBF followed by decrease within a short period. After a few hours, rCBF values had fallen to pre-occlusion levels. During the 6 hours occlusion, electrical activity became almost flat, and recovery following reflow was not seen. The CO2 response was found to be disturbed immediately following vascular occlusion and also did not recover following reflow. In contrast, among the animals in which hemorrhagic foci were not found, reflow resulted in recovery of rCBF to pre-occlusion levels within a short period. Electrical activity of the brain and CO2 response were found to be maintained throughout the period of occlusion and thereafter in these animals.

Animals↗
PubMed1983

[Combined use of mannitol and perfluorochemicals in experimental cerebral ischemia].

Using the "canine model of complete ischemic brain regulated with a perfusion method" in which it is possible to control the degree of blood flow to a cerebral hemisphere via a perfusion pump, the effects of mannitol (which acts as a free radical scavenger) and perfluorochemical emulsion (PFC, which has 0.1 micrograms of average particle size and a high oxygen-carrying capacity) on cerebral ischemia were investigated. After pretreatment with the drugs, blood flow was reduced via the pump to 1/10 of the normal flow volume and 1 hour later, return to a normal flow was allowed. Subsequent changes in electrical activity were observed and the effects of the drugs evaluated. In the control group, no recovery of electrical activity was seen, but in the animals treated with either mannitol or PFC, incomplete, yet distinct recovery was apparent. In the animals administered with mannitol together with PFC, however, marked recovery was evident. These experimental results indicated that a combined administration of PFC and mannitol is effective in protecting the brain from cerebral ischemia.

Animals↗
PubMed1983

[Administration of mannitol for severe superior sagittal sinus thrombosis].

A cured case of superior sagittal sinus thrombosis is reported. The patient, a 26-year-old man, also displayed severe complications such as hemorrhagic infarction and status epilepticus. Although his prognosis was considered to be extremely poor, conservative treatment, with mannitol, steroid, anticonvulsants, etc. was effective, and he was discharged without any neurological deficit. This report discusses the clinical course, CT findings, angiographical findings and regional cerebral blood flow (rCBF). At first, CT showed no abnormal findings, but hemorrhagic infarction was detected on the 3rd day after the onset. Follow-up CT showed subcortical low density area, hemorrhagic infarction with perifocal brain edema, midline shift etc; the focus of hemorrhagic infarction was almost absorbed 2.5 months after the onset. Cerebral angiogram showed not only the obstruction of the superior sagittal sinus but also that of cortical veins of cerebral convexity at first. Follow-up angiogram showed the development of collateral circulations such as deep cerebral, ophthalmic and emissary veins. On CBF study, low rCBF at the bilateral parasagittal region was observed, but marked increase of rCBF was measured in the parasagittal region, especially at the site of hemorrhagic infarction after the administration of 20% mannitol. We, therefore, consider mannitol as an effective agent for the treatment of cerebral sino-venous thrombosis.

Adult↗
PubMed1983

[Villaret's syndrome due to extra-cranial internal carotid aneurysm: a case report].

A 69 year-old male was admitted to our clinic with the chief complaint of hoarseness and difficulty in swallowing. These symptoms occurred about 5 months after penetrating neck injury. Neurological examination revealed right ninth to twelfth cranial nerves palsy and Horner's syndrome. Plain skull X-P demonstrated two broken pieces of glass below the right mastoid processus. The right carotid angiogram showed a 45 x 25 mm aneurysm originated from the right internal carotid artery just below the carotid canal. As the first operation, gradual occlusion of right internal carotid artery combined with the right STA-MCA anastomosis was performed. But two days after complete occlusion, left hemiparesis and pseudobulbar palsy appeared. Two months after such episode, aneurysm and the pieces of glass were removed. He discharged on foot with the improvement of the symptoms of lower cranial nerves. Villaret's syndrome caused by the traumatic aneurysm of extracranial internal carotid artery is rare. This case seems to be the first report in Japan.

Aged↗
PubMed1983

[CT scan in ruptured intracranial aneurysm--comparative studies of initial bleeding and rebleeding].

The differences between initial bleeding and rebleeding due to ruptured intracranial aneurysm was investigated by CT. The study included 120 cases of ruptured cerebral aneurysm; 71 cases had only one bleeding and 49 cases had rebleeding. All the cases underwent CT examinations within 2 weeks following bleeding. Subarachnoid hemorrhages were classified into three groups according to the CT findings: Diffuse high type--high density areas in the entire basal cistern; Localized high type--high density area in a restricted part of the basal cistern; and Iso or Low type--no high density areas in the basal cistern. CT scans done within 24 hours following initial bleeding showed Diffuse high type in 96% of the cases and Localized high type in 4%. On the other hand, in rebleeding cases, Diffuse high type was 50%, Localized high type 25% and Iso or Low type 25%. In rebleeding cases within three days following initial bleeding, Diffuse high type was 90% and Iso or Low type 10%. However, between day 4 and day 14, Diffuse high type was 14%, Localized high type 42% and Iso or Low type 42%. After day 15, Diffuse high type was 36%, Localized type 36% and Iso or Low type 28%. Intracerebral hematoma and/or ventricular hemorrhage secondary to ruptured aneurysms were also investigated. Following initial bleeding, 18% of cases showed intracerebral and/or ventricular hemorrhage, however, the incidence increased up to 59% in rebleeding cases.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

[Sequential changes of experimental cerebral infarction--CT and histological studies].

Using the canine thalamic infarction model, it was found that hemorrhagic infarction can be produced at a high frequency following recirculation after 6 hours of vascular occlusion. In the current study, sequential changes of histological findings and CT findings in the infarctic foci were investigated. Low absorption areas in the CT scans were apparent already by the 2 hours of recirculation. Thereafter, the boundary with the periphery became more distinct and was visible through the 6th week. Contrast enhancement could be seen 2 hours after recirculation and between 7 and 14 days thereafter. In histological study, leakage of red blood cells from the capillaries and small venules in the focus could be seen 2 hours after recirculation. This finding is thought to indicate that the mechanism of contrast enhancement is extravasation during this period. Macrophages began to infiltrate the focus from the surrounding tissue between the 2nd and 5th day. Between the 7th and 14th day, destruction of nerve cells and capillaries was seen, together with the formation of small cavities, but many small vessels from the peripheral tissue heading toward the focus were regenerated. It is thought likely that the contrast enhancement seen during this period was due to leakage of the contrast medium from these newly regenerated vessels. From around the 3rd week, destruction of the regenerated vessels from the periphery of the focus began and cavity formation progressed. By the 6th week, only a small amount of fibrous neural material remained and the cavity was well-formed.

Animals↗
PubMed1983

[Combined radio-immuno-chemotherapy for medulloblastoma].

The authors studied 10 cases of medulloblastoma by CT scan and reviewed treatment, result and pathological findings. Combined radio-chemo-immuno therapy (RAFP therapy: Radiation, ACNU, FT-207, PSK) resulted in 5 cases of complete remission and 4 cases of partial remission. In the most effective group, the tumor shadow disappeared after irradiation of 3,000 rad. In 2 cases the tumor shadow did not disappear after RAFP therapy, and total removal was performed. In pathological examination highly differentiated cell groups were recognized. For medulloblastomas we recommend a combination of radiation, chemotherapy and immunotherapy, such as RAFP therapy, and if the tumor shadow still remains, surgery.

Adjuvants, Immunologic↗
PubMed1983

[Meningioma with extracranial multiple metastases--a case report].

A case of meningioma with extracranial multiple metastases is reported in this paper. The patient was a 21 years old woman. The removal of the convexity meningioma and the surrounding intracerebral hematoma in the left occipital region was performed. The histological diagnosis of the tumor was malignant fibroblastic meningioma. The patient was given radiotherapy, 6000 rads in the whole brain. Two years later, the recurrence occurred. The metastasis appeared to the lung and six months later to the liver. There occurred an intraperitoneal bleeding from multiple liver metastases and the patient died in November, 1980. The mode and site of the metastases have been discussed with a review of the literature.

Adult↗
PubMed1983

[Experimental study of cerebral protective substances in ischemia--effect of vitamin E].

Using the "Canine model of complete ischemic brain regulated with a perfusion method", the effects of vitamin E which acts as an antioxidant on cerebral ischemia were investigated. After pretreatment with vitamin E by oral or intravenous administration, cerebral blood flow was reduced to 1/10 the normal state and one hour later, return to a normal state allowed. Subsequent changes in electrical activity were observed and the effects of the vitamin E were evaluated. In the control group, no recovery of electrical activity was seen. While in the group of vitamin E administration, the survival time was not prolonged but the recovery time was shortened statistically in the dogs given 30 mg/kg of vitamin E intravenously. Furthermore, in the group treated with vitamin E, distinct recovery of EEG potentials at three hours after recirculation was apparent. These effects were more favorable in the case of intravenous administration than in the case of oral administration. These experimental results indicated that administration of vitamin E is effective in protecting the brain from cerebral ischemia.

Administration, Oral↗
PubMed1983

Portions of tone pips contributing to frequency-selective auditory brain stem responses.

The portions of tone pips that are effective in increasing the amplitudes of auditory brain stem responses were studied using 6 cats. The responses evoked by pips with identical slopes but different rise times were compared to one another. The results indicated that the effective portion of the tone pips extended more than 4 ms from onset at 500 and 1 000 Hz, and more than 2 ms at 2 000 Hz. Each cycle within these ranges contributed to the increase in response amplitude. These results support the contention that the frequency selectivity of the brain stem response elicited by tone pips is sufficient for objective audiometry.

Acoustic Stimulation↗
PubMed1982

[Sleep in vegetative state patients and recuperated cases from vegetative states (author's transl)].

Twenty-four hours polygraphic recording of EEG, electrooculogram and EMG were performed on 8 vegetative state patients and 4 recuperated cases, and the differences of the sleep pattern between two groups were discussed. It was difficult to divide the sleep pattern into normal four stages, because the frequency of EEG in vegetative state patients were very slow. So we divided it into the following 4 patterns; awake, shallow sleep, deep sleep and REM sleep. The sleep in vegetative state patients was interrupted by short duration and appeared at random during day and night. The amount of sleep in vegetative state patients increased proportion to severity of vegetative state. Rate of shallow sleep of them was high. REM sleep was seen in all the cases, but its cycle and lasting time were different in each case. The rate of shallow sleep prior to REM sleep was lower than normal pattern and the change of sleep state was atypical. Few hump and spindle wave appeared. For the reasons mentioned above, the sleep pattern in vegetative state patients was far from physiological sleep. On the other hand, the sleep in recuperated patients was more similar to the normal pattern than that of vegetative cases, but the rate of shallow sleep was as high as the vegetative cases. REM sleep was irregular and the change of sleep was also atypical. Therefore, the sleep pattern in recuperated patients was also far from physiological sleep, though it was better than that of vegetative cases.

Adult↗
PubMed1982

Reversible inhibition by human serum lipoproteins of cell proliferation.

Normal human serum or plasma was studied for the presence of inhibitors of cell proliferation by assaying inhibition of incorporation of labeled thymidine into acid-insoluble fraction using human FL cells. Lipoprotein fraction obtained by gel filtration through Sepharose 4B and by KBr density gradient centrifugation was found to play a major part of the inhibitory activity of the serum. It was also shown that the inhibitory activity resides in low-density lipoprotein (LDL). The addition of the lipoprotein fraction to growing FL cells caused an early decrease in the transport of uridine and thymidine across the membrane. This change in the permeability of membrane was followed by the preferential inhibition of DNA synthesis and a reduction in the percentage of mitotic cells in the cell population. The inhibition of the growth was reversible and was observed in various types of cells irrespective of species.

Animals↗