Search PubMed⌕ Search

Biomedical subjects

J Sugar

Publications and source records attributed to J Sugar.

At least 145 records · Page 8Linked to original sources
PubMed1980

Automated vitrectomy in eyes with vitreocorneal touch associated with corneal dysfunction.

Of the results evaluated in 17 patients who had vitrectomy for aphakic vitreocorneal touch associated with corneal edema, nine patients had satisfactory results. Factors associated with a favorable outcome were as follows: (1) early vitrectomy; (2) previtrectomy visual acuity better than 6/120 (20/400); (3) uncomplicated cataract operation and postoperative course, and (4) broken rather than intact hyaloid face. Postoperative cystoid macular edema contributed to decreased visual acuity in eight of 12 patients.

Aged↗
PubMed1980

Endogenous dissemination of genital Herpesvirus hominis type 2 to the eye.

A 33-year-old man developed Herpesvirus hominis type 2 (HVH-2) eye disease following a herpetic lesion of the penis. The sequence of ocular involvement suggested that the virus had been transmitted endogenously from the genital lesion: granulomatous iritis was followed by interstitial keratitis and then by dendritic keratitis. Recurrent bacterial ulcers ultimately required a conjunctival flap. The course of this man's ocular disease as well as those of other reported cases of HVH-2 adult eye infections appeared to be more severe and prolonged than that of the average patient with ocular herpes type 1 infection.

Adult↗
PubMed1980

Effect of systemic indomethacin on corneal graft survival in rabbits.

We investigated the effect of systemic indomethacin on corneal graft survival in rabbits. Two weeks following corneal transplants, skin grafts were exchanged between donor-recipient pairs. Indomethacin was started one day prior to transplant and was continued for the duration of the study. Mean graft survival was twice as long in the indomethacin-treated group (P less than 0.001) than in the untreated rabbits.

Animals↗
PubMed1980

Bacterial contamination of corneal donor tissue.

We studied bacterial contamination of corneal donor material following processing by two techniques prior to immersion in McCarey-Kaufman medium. If the whole eye was immersed in Neosporin, 24.5% of cultures were positive. If eyes were only rinsed with Neosporin, 47.5% of cultures were positive. No eyes receiving this tissue developed infections. Cultures were much more likely to be positive if the donors had been on a respirator prior to death.

Adolescent↗
PubMed1980

Pathological features of N-methyl-N'-nitro-N-nitrosoguanidine induced neoplastic and preneoplastic lesions of rat stomach.

Malignant transformation of rat stomach was studied after oral administration of MNNG. The lesions were investigated with cytomorphological and histochemical methods, while the alkaline phosphatase (ALP) isoenzyme pattern was investigated by means of gel electrophoresis. Hyperdiploid-aneuploid DNA values were observed in dysplasias, as well as in carcinomas. The liver type ALP isoenzyme could be detected in intact and regenerative gastric mucosa. It also occurred in atypical hyperplasia and carcinoma. Placental type ALP isoenzyme was absent in all intact or regenerating gastric mucosa, but present in atypical hyperplasias and carcinomas. It can be concluded that DNA aneuploidy and the presence of placental type ALP are indicative of malignant transformations. The MNNG-induced adenomatous hyperplasia associated with atypia behaved like cancer and can thus be regarded as an obligatory preneoplastic lesion.

Adenoma↗
PubMed1979

Renal clearance of estriol and its conjugates in normal and abnormal pregnancies.

Renal clearance of estriol (E3), E3-3-sulfate (E3S), E3-16-glucuronide (E316G), E3-3-glucuronide (E33G), and E3-3-sulfate-16-glucuronide (E3SG) has been measured in 13 normal and 17 abnormal pregnancies between the 33rd and 40th weeks of gestation. The methodology involved a chromatographic separation on a celite column in the presence of tritiated tracers, enzymic hydrolysis of the conjugates, and measurement of the E3 moiety by a specific RIA. Preeclampsia (eight patients) was characterized by a significant decrease of renal clearance for all conjugates except E33G. In contrast to that pattern, a patient with cholestatic icterus had normal clearances except for E33G, which was reduced to less than 15% of its normal mean value. Administration of ampicillin to a pregnant woman induced an important decrease of all E3 clearances, especially for E33G which decreased to nearly 1% of its initial value; normal clearances were resumed within a week after the end of the treatment. In a small number of complicated pregnancies, E3 clearances were normal. A significant correlation between the renal clearance of E316G and that of urea and creatinine has been demonstrated.

Estriol↗
PubMed1979

Corneal manifestations of the systemic mucopolysaccharidoses.

Newer biochemical understanding of the mucopolysaccharidoses now allows a better classification of these diseases. The dermatan and keratan sulfate-storing diseases have corneal clouding. The heparan sulfate-storing diseases have retinal changes and usually central nervous system manifestations.

Child↗
PubMed1978

The effect of phacoemulsification on corneal endothelial cell density.

Seventy-six patients who had undergone unilateral phacoemulsification of cataracts had their endothelial cell density (ECD) measured by specular microscopy. When compared with the unoperated contralateral eye, there was a mean decrease in ECD of 33.8%. Ten patients who had undergone unilateral intracapsular cataract extraction had a mean decrease in ECD of 14.9%. Cataract extraction by phacoemulsification appears to be more traumatic to the corneal endothelium than is intracapsular extraction.

Adult↗
PubMed1978

Endothelial trauma and cell loss from intraocular lens insertion.

Eighty-six patients who underwent intraocular lens implantation in one eye, with no surgery in the contralateral eye, were examined by specular microscopy. The mean endothelial cell density (ECD) was 39.5% lower in the operated eye. The loss of ECD was roughly proportional to the endothelial trauma from the intraocular lens at the time of surgery.

Aged↗
PubMed1978

Scanning electron microscopy of intraocular lens and endothelial cell interaction.

Scanning electron microscopic evaluation of two intraocular lenses removed at keratoplasty for pseudophakie bullous keratopathy demonstrated apparently viable endothelial cells adherent to their surfaces. These presumably adhered to the lens implants at the time of their insertion and confirm this as a mechanism for endothelial damage and subsequent corneal edema from intraocular lens implantation.

Aged↗
PubMed1977

Ocular manifestations of toxic epidermal necrolysis associated with allopurinol use.

A 54-year-old man was receiving allopurinol therapy to treat hyperuricemia that followed an inferior wall, myocardial infarction. After three weeks of allopurinol therapy, the patient developed signs and symptoms of toxic epidermal necrolysis that included pseudomembranous conjunctivitis with ulcerative lesions on the lids and conjunctiva, and punctate corneal staining with subsequent corneal abrasions. Treatment with topical antibiotics and artificial tears relieved the symptoms somewhat, but punctate staining and dry eyes persisted after 14 months of follow-up. Bilateral corneal ulcers developed and necessitated conjunctival flaps in each eye. Visual acuity in each eye was 20/40.

Allopurinol↗
PubMed1977

Radioimmunoassay of estriol-16-glucuronide.

A specific radioimmunoassay of estriol-16-glucuronide has been developed, using an antiserum obtained by immunization of rabbits against estriol-16-glucuronide-BSA. The assay does not require hydrolysis, extraction and purification, but only a dilution of the crude sample. This constitutes the main advantage of the precedure. Accuracy, precision and sensitivity of the method are similar to those reported for other radioimmunoassays of estriol. Its specificity is good for the measurement of estriol-16-glucuronide in urine and in amniotic fluid, but not in serum of pregnant women, which apparently contains material interfering with the radioimmunoassay, at dilutions of less than 1/100. A significant correlation was observed between estriol-16-glucuronide and total estriol in urine during pregnancy; however, the contribution of the glucuronide to the total increases as pregnancy progresses, rising from 50% for a total of 5 mg/24 h to 85% for a total of 50 mg/24 h. The present radioimmunoassay can be used as a quick and reliable method for the measurement of urinary estriol-16-glucuronide in high risk pregnancies.

Amniotic Fluid↗
PubMed1977

Variable expression in flecked (speckled) dystrophy of the cornea.

Five members of a three-generation pedigree had flecked corneal dystrophy. The number of flecks varied from patient to patient, and one individual was affected in only one eye. Visual acuity was normal in all family members. Homocystinuria also occurred in this family, but appeared to be coincidental. Central cloudy dystrophy of the cornea appears to be genotypically identical to flecked dystrophy of the cornea but is phenotypically distinct.

Adult↗