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Biomedical subjects

J Starý

Publications and source records attributed to J Starý.

At least 91 records · Page 5Linked to original sources

Immunologic characterization of T-lymphoproliferative disorders by monoclonal antibodies.

A series of 11 mouse monoclonal antibodies reactive with human T lymphoid cells at different stages of differentiation was used for immunological classification of leukaemic cells of 16 patients with T cell lymphoproliferative disorders by using a fluorescence assay. The majority of T-ALL cells had an immature or early thymic phenotype and T lymphoblastic lymphoma had phenotypes corresponding to different levels of more mature stages of T cell differentiation, Two cases of T-CLL and one adult patient with mycosis fungoides had mature T cell phenotypes being T-3+, T-4-, T-8+, cytotoxic/suppressor cell types and one case of T-CLL had T-3+, T-4+, T-8-, "helper/inducer" cell type, too. These results suggested that surface marker analysis in T cell lymphoproliferative disorders may be used as a highly reproducible immunological classification system that will provide additional information about phenotypes of leukaemic cells in connection with morphological analysis and clinical diagnosis.

Animals↗

The cumulation of zinc and cadmium in fish (Poecilia reticulata).

Zinc-65 and cadmium-115 m were used for the investigation of the uptake and the release of zinc and cadmium in fish. It has been found that the uptake of these elements directly from water is relatively low. Zinc and cadmium, consumed by fish in food, are released with the biological half-time 0.25 +/- 0.05 days (94%) and 65 +/- 9 days (6%) for zinc, 0.25 +/- 0.05 days (98.5%) and 36 +/- 6 days (1.5%) for cadmium. The comparison with data obtained for mercury species shows that the cumulation of these elements in fish increases in the order cadmium, zinc, inorganic mercury (II), phenylmercury and methylmercury.

Animal Feed↗

The cumulation of chromium and arsenic species in fish (Poecilia reticulata).

Chromium-51 and arsenic-74 were used for the investigation of the uptake and the release of different chromium and arsenic species in fish. It has been found that only trimethylarsine can be rapidly taken up directly from water. The release of chromium(III), consumed by fish in food, is very rapid: about 99.9% of chromium is released within a few days. The same results were obtained with chromium(III) acetylacetonate or chromium(III) ethylenediaminotetraacetate. About 95% of arsenic acid, methylarsonic acid, dimethylarsinic acid or arsenic(III) diethyldithiocarbamate are released within a few days whereas the remaining arsenic is released with the biological half time 35 +/- 5 days.

Animal Feed↗

The cumulation of methylmercury in fish (Poecilia reticulata).

Methylmercury labelled with mercury-203 was used for the investigation of the uptake and the release of methylmercury in fish. It has been found that methylmercury compounds adsorbed on fish food remain completely in fish and that they are released with the biological half-time of 110 +/- 20 days. The cumulation of methylmercury from water is very rapid: the cumulation constant is 237 +/- 67 days-1. Equations for the calculation of the concentration of methylmercury in fish were derived and compared with the uptake of phenylmercury and inorganic mercury.

Animal Feed↗