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J Soga

Publications and source records attributed to J Soga.

At least 37 records · Page 2Linked to original sources
PubMed1998

Statistical evaluation of 2001 carcinoid cases with metastases, collected from literature: a comparative study between ordinary carcinoids and atypical varieties.

This study aimed at obtaining a better understanding of the malignant characteristics of carcinoids (gut endocrinomas) of the digestive system. After excluding cases with no possible individual identification as for age and sex, 2001 carcinoid cases with metastases among 5647 of the digestive system computerized in the Niigata Registry were thus subject to the present analysis. These cases were divided into two groups: [A] 1719 with ordinary carcinoid histology and [B] 282 with atypical varieties including argyrophil (endocrine) cell carcinomas, small/oat cell carcinomas of endocrine type, composite carcinoid-adenocarcinoma varieties and other neuroendocrine tumors. In many aspects, a comparative analysis demonstrated statistical differences between [A] and [B]: average age (55.7 vs 60.1), the rates of metastases (34.4% vs 55.6%), the association of carcinoid syndrome (21.4% vs 2.8%), tumor size 20mm or less (42.2% vs 22.5%), depth of invasion down to the submucosa (21.6% vs 11.7%) and transmural invasion (34.3% vs 47.7%), immunohistochemistry of neuron-specific enolase (86.5% vs 66.7%), chromogranin (86.1% vs 67.6%), vasointestinal polypeptides, ACTH and alpha-fetoprotein, and the 5-year survival rate (61.4% vs 17.9%). No statistical differences between these two groups were found in the male to female ratio, serotonin activities and Grimelius argyrophilia. Although no generally acceptable definite criteria and definition for atypical carcinoid varieties have yet established, neoplasias of this category seem to have a wide range of histological, histochemical, immunohistochemical, ultrastructural and biochemical features that may mostly be placed in between ordinary carcinoids and ordinary carcinomas.

Adenocarcinoma↗
PubMed1998

Esophageal endocrinomas, an extremely rare tumor: a statistical comparative evaluation of 28 ordinary carcinoids and 72 atypical variants.

Esophageal endocrinomas are an extremely rare neoplasm. The present study aimed to evaluate multiphasic clinical and pathologic aspects of 100 cases of esophageal endocrinomas, consisting of 28 cases of ordinary type carcinoids and 72 atypical varieties collected from worldwide literature and recorded on computer in the Niigata Registry. The evaluation of esophageal endocrinoma cases was on most occasions carried out in accordance with a comparison between ordinary carcinoids and atypical varieties. Esophageal endocrinomas were generally characterized by a preponderance of male patients and an older age group. They also exhibited a higher metastasis rate, and a lower incidence of carcinoid syndrome than overall endocrinomas of the digestive series. They further indicated a probable unfavorable postoperative outcome as compared to endocrinomas in most other digestive organs. Ordinary carcinoids of the esophagus were characterized by smaller size at detection, lower metastasis rate, and better postoperative outcome than the atypical variety group. Because of the extremely small number of cases of esophageal endocrinomas, additional case reports are in future expected to be satisfactorily documented as a valuable record.

Adult↗
PubMed1998

Carcinoids of the colon and ileocecal region: a statistical evaluation of 363 cases collected from the literature.

The colon and ileocecal region are rare sites of origin for gastrointestinal carcinoids. This study evaluates the present status and characteristics of carcinoids of these particular sites in a statistically reliable number of cases and offers fundamental information for future analysis and treatment of these neoplasias. A total of 363 cases of colonic and ileocecal carcinoids were collected from international literature and evaluated in the computer analyzing system. For the final evaluation, 279 cases with sufficient information, consisting of 203 colonic and 76 ileocecal carcinoids, were selected for analysis. In addition, 69 cases of atypical varieties in identical sites were studied for a comparison of 5-year survival rates with the 279 ordinary colonic and ileocecal carcinoids. The characteristic features of colonic and ileocecal carcinoids included: 1) a female preponderance and older age group in the ileocecal carcinoids; 2) a higher incidence of carcinoids in the cecum as compared to those of the rest of the colon followed by the ileocecal region; 3) a high incidence of palpable abdominal tumors resulting from a tendency of the tumors to be large (89.7% were over 2 cm); 4) a high incidence of metastases (61.3%); 5) a high incidence of Grimelius argyrophilia (100.0%) and argentaffin cell type (85.7%) in ileocecal carcinoids; 6) a low detection rate of serotonin in immunohistochemical (66.7%) and laboratory (68.7%) evaluation; and 7) a low postoperative 5-year survival rate (40.5% by the crude calculation method and 65.3% by the Kaplan-Meier method). The present statistical evaluation disclosed a considerable delay in detecting colonic and ileocecal carcinoids resulting in extensive and aggressive surgical treatments and poor postoperative outcomes.

Adolescent↗
PubMed1998

Tumor recurrence in patients with early gastric cancer: a clinicopathologic evaluation.

We conducted a retrospective study on 711 patients with early gastric cancer. Twenty-two patients (4.0%) developed recurrent disease and 21 died of recurrence during this study. One hundred and sixty-three patients died of unrelated or unknown causes. The recurrence patterns of 22 patients were as follows: hematogeneous metastasis to the liver in 11 patients, peritoneal dissemination in 3, recurrence in the remnant stomach in 3, and in the distant lymphonodes in 1. The mean survival period of patients with recurrent disease was 50.4 months, and 7 of these patients (31.8%) died more than 5 years after surgery. A retrospective clinicopathologic evaluation of the 22 patients and 526 patients without recurrence revealed significant differences between the two groups with respect to mean age at the time of surgery (62.5 years in the recurrent group vs 57.3 years in the nonrecurrent group), tumor size (41.2 vs 30.6 mm), depth of invasion (submucosal cancer: 19 vs 256), lymphnode metastasis (11 vs 48), lymphatic (11 vs 89) and venous (7 vs 18) invasion, and operative curability (curability B: 8 vs 48). Three patients with intramucosal cancer who died of hematogenous and/or peritoneal recurrence within 7 years after surgery had neither lymphnode metastasis nor lymphatic or venous invasion, suggesting that new techniques are needed for prediction of recurrent disease in patient with early gastric cancer.

Adult↗
PubMed1997

Carcinoids of the rectum: an evaluation of 1271 reported cases.

The present study was conducted to evaluate the current status of rectal carcinoids from multiple systemic aspects, based on extensive information provided by 1271 cases cited in 465 international articles published since 1912. Each case report was carefully read, computerized, and analyzed by the gut-pancreatic endocrinoma analysis system (Niigata Registry). To avoid case duplication, cases without individual identification, such as the age and sex of the patient, and those with identical clinical and laboratory data and institutes of source, were excluded. Where appropriate, selected cases from an overall gastrointestinal (GI) series consisting of 4461 cases similarly documented in the same Registry were referred to for comparison. The representative characteristics of rectal carcinoids consisted of a male preponderance, small-sized tumors of 10 mm or less at detection, predominant submucosal invasion with a relatively high incidence of metastases, a high incidence of hematogenous spread, a predominant histology of the B-type growth pattern, a low rate of silver reactivity, the infrequent association of carcinoid syndrome, and a relatively high rate of mortality within 5 years after removal of the lesions.

Adolescent↗
PubMed1997

Gastric carcinoids: a statistical evaluation of 1,094 cases collected from the literature.

Gastric carcinoids are a rare gut endocrinoma, and only a few series dealing with limited aspects have been published. This study evaluates the present status and characteristics of gastric carcinoids in a statistically reliable series of 1,094 cases that were carefully evaluated, computerized, and analyzed by the "Gut-Pancreatic Endocrinoma Analyzing System." Routine statistical analysis was carried out on 1,011 patients, excluding 83 with atypical carcinoids, focusing on clinical manifestations, location, depth, and size of the lesions in relation to metastases, immunohistochemistry, carcinoid syndrome, serotonin activity, electron microscopy, multicarcinoid complex with type A gastritis, and postoperative outcome. A tumor size of 20 mm or less comprised 60.8% of the series, with a metastasis rate of 15.1%, and depth of invasion to the submucosa occupied 53.8%, with a metastasis rate of 13.2%. Carcinoid syndrome was encountered in 4.0% of the patients. Elevated serotonin activity was detected in 22.3% overall and in 67.7% of the patients with carcinoid syndrome (P < 0.01). Multicarcinoid complex with type A gastritis was detected in 140 of 347 patients with multicarcinoid complex, and 97.1% had associated lesions in the nonantral regions of the stomach. A comparative evaluation between patients with and without type A gastritis indicated a number of significant differences including male to female ratio, age distribution, location, tumor size, depth of invasion, metastasis, and prognosis.

Adolescent↗
PubMed1997

Carcinoids of the small intestine: a statistical evaluation of 1102 cases collected from the literature.

A total of 1102 cases of jejunoileal carcinoids collected from 516 articles reported by over 35 countries or related areas were evaluated. Among these 1102 cases. 93 cases of Meckel's diverticular and 969 cases of remaining jejunoileal carcinoids could be effectively analyzed. Multiple clinicopathologic aspects were investigated including clinical manifestations, location, depth and size of the lesions related to metastases, immunohistochemistry, electron microscopy, carcinoid syndrome and serotonin activity. Jejunoileal carcinoids were characterized by a male preponderance with an age group older than that in the extraappendiceal gastrointestinal (GI) series. They also had a significantly aggressive malignant nature exhibiting a high metastasis rate particularly evident in small-size lesions with submucosal invasion. A high incidence of argentaffin cell type and carcinoid syndrome with high serotonin activity was also exhibited by jejunoileal carcinoids.

Age Distribution↗
PubMed1992

[Recurrent thymic carcinoid tumor--report of a case and review of the literature].

A case is presented of a 48-year-old male patient with thymic carcinoid tumor who was operated on twice and followed for 12 years. The original tumor was removed in 1979, and a recurrent tumor was removed 4 years later. Multiple metastases to the lungs, pleura and lymph nodes of the neck were found in 1988; chemotherapy (BAPP) and radiation therapy were not effective, and there was subsequent subcutaneous invasion of the anterior chest. We also discuss the 153 cases of thymic carcinoid tumor reported in the Japanese literature in the Niigata Carcinoid Registry.

Carcinoid Tumor↗
PubMed1990

[A carcinoma of the reconstructed gastric tube after a radical esophageal cancer operation].

Reported are five patients who developed a carcinoma of the reconstructed gastric tube. In 3 of the 5 patients, the esophageal cancer was preceded by a gastric cancer, and the intervals before the gastric cancer was detected were 34, 24, and 60 months. The gastric tube the had been reconstructed by the retrosternal rout was resected with a median sternotomy in cases 1 and 2. In case 3, since a liver and lung metastasis had been detected by routine examination, surgery was not performed. Cases 4 and 5 had an esophageal cancer associated with a simultaneous early gastric cancer located in the lesser curvature of the upper body. Thus, a esophagectomy and a partial gastrectomy were performed. Twenty-eight and 21 months later, respectively, an early gastric cancer was found at the stump of the gastric tube that had been reconstructed by the retrosternal route. Endoscopic laser therapy was subsequently employed for both patients. Because of these findings, the author have concluded that postoperative serial examination of the gastric tube are very important, since cases of a gastric tube cancer are increasing.

Aged↗
PubMed1989

[Carcinoids].

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Antineoplastic Combined Chemotherapy Protocols↗
PubMed1988

[Clinicopathological study of early gastric cancer--indication of conservative surgery and radical endoscopic treatment of early gastric cancer].

Clinicopathological factors such as depth of cancer invasion, size, gross type, frequency of metastases to regional lymph nodes, and distant prognosis were evaluated in last consecutive 339 cases with solitary early gastric cancer. The conservative surgery, that is, subtotal gastrectomy with complete dissection of lymph nodes of group 1 and selective celiac group and partial bursectomy, would be indicated for early gastric cancers located in antrum or corpus. But if the metastasis to the group 2 lymph nodes is suspected during the surgery, it is necessary to dissect lymph nodes en bloc more than group 2. The results, concerning the type of early gastric cancer without lymph node metastasis and the indication of endoscopic treatment, were as follows; 1. Intramucosal cancer of elevated type less than 2 cm in diameter. 2. Intramucosal cancer of depressed type less than 1cm in diameter, without peptic ulcer within the lesion, and a differentiated tubular adenocarcinoma histologically. 3. Intramucosal cancer of flat type less than 2 cm in diameter. But it is difficult to detect the depth of cancer invasion and lymph node metastasis preoperatively. We would emphasize that endoscopic treatment should be indicated in the case for which surgical treatment is not indicated.

Adult↗
PubMed1986

[Diagnosis and treatment of carcinoids of the large intestine].

A total of 1,279 cases of carcinoids reported in Japan included 882 cases (69.0%) in the digestive organs. Among the latter cases, carcinoids of the large intestine consisted of (A) 320 cases (36.3%) in the rectum and (B) 46 cases (5.2%) in the ileocecal region, cecum and colon excluding the rectum. The predominant difference of signs and symptoms between (A) and (B) was a high incidence of large palpable abdominal tumors and obstructive findings (ileus) in the latter and a high incidence of small-sized tumors and anorectal disturbances such as hemorrhoids, anal bleeding or anal pain in the former. The incidence of the carcinoid syndrome in (B) was 13.0%, considerably higher than the average of the Japanese series (4.1%) and the America-Europe series. Silver impregnation methods with a combination of Grimeluis' argyrophil and Masson-Fontana's argentaffin reactions were considered to be useful methods for diagnosis of carcinoids of the large intestine. The rate of metastasis in relation to tumor size in the Japanese series was 6.1% for lesions less than 1.0 cm in size and 25.7% for lesions between 1.0 and 2.0 cm. Because of a high incidence of metastasis in (B), 41.3%, greater than that for ordinary carcinoma in the identical sites, it was emphasized that surgical treatment of carcinoids of the large intestine should be principally in accordance with that for ordinary carcinomas.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1985

Granular cell tumors of the esophagus: a report of two cases and review of the literature.

Two patients with granular cell tumors of the esophagus are presented. Both were men, 54 and 51 years old, respectively, and without tumor-related complaints. Diagnosis was made by esophagogram and endoscopic biopsy. The two patients were treated with a left thoracotomy and local excision of the tumors. A review of the world literature was carried out and data of general interest were collected. The symptoms and management of esophageal granular cell tumors, as well as histogenesis, are discussed.

Adult↗