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Biomedical subjects

J Small

Publications and source records attributed to J Small.

33 records · Page 2Linked to original sources

Alphaxalone/alphadolone anaesthesia in the lamb.

Alphaxalone/alphadolone (12 mg/ml) was administered by both the intramuscular and intravenous routes in an investigation of its action in newborn lambs. Useful anaesthesia was produced with an intravenous injection of 6 mg/kg bodyweight and with a divided intramuscular injection of either 9 or 12 mg/kg, one half of the dose being injected into the quadriceps mass of each hind leg. In all cases the recovery period was quiet and of short duration. Transient depressions of heart and respiratory rates were observed during anaesthesia but these were judged to be clinically acceptable. A single intramuscular injection was less effective probably because of slow absorption from the single site. The results suggest that this drug is a suitable injectable anaesthetic agent for the newborn lamb.

Anesthesia

Causes of hypothermia in 89 lambs.

The causes of hypothermia in 89 lambs were identified on the basis of history and clinical biochemistry. Excessive heat loss accounted for 24 per cent of the cases, and depressed heat production because of either severe hypoxia during birth, immaturity or starvation accounted for 72 per cent. Exhaustion of energy reserves and hypoglycaemia were marked characteristics of lambs which became hypothermic after 12 hours of age. Most of the lambs were either twins or triplets. The implications of the findings for both the treatment and prevention of hypothermia in newborn lambs are discussed.

Animals

Resuscitation of hypothermic lambs.

A technique was developed for the resuscitation of hypothermic newborn lambs. This technique consisted of three major components: the administration of glucose solution by intraperitoneal injection to lambs aged six hours or more in order to reverse hypoglycaemia (10 ml/kg of a 20 per cent solution); rewarming the lambs in air at 40 degrees C; and careful attention to the nutrition and husbandry of the lambs after rewarming. The results indicate that careful application of this technique during lambing would considerably reduce the losses from hypothermia.

Animals

Effects of colostrum on summit metabolic rate in Scottish blackface lambs at five hours old.

The feeding of colostrum to newborn lambs led to a 17 to 20 per cent increase in summit metabolic rate estimated at five hours of age. This increase would significantly enhance the survival potential of the newborn lamb in the field. Respiratory quotient during summit metabolism and changes in plasma composition suggested that the carbohydrate content of the colostrum was a major contributor to the increase in summit metabolic rate.

Animals

Some changes in the composition of maternal and fetal plasma from chronically catheterised sheep during short periods of reduced feed intake in late pregnancy.

Changes in the composition of maternal and fetal plasma from nine sheep were followed during periods of reduced feed intake lasting four to seven days. Feed rations were reduced between 120 and 128 days of gestation and this produced hypoglycaemia in mother and fetus. In each sheep there was a significant negative correlation between the glucose and corticosteroid concentrations in both maternal and fetal plasma, and there were positive correlations between the maternal and fetal plasma concentrations of glucose, and between the glucose and fructose concentrations of fetal plasma. Maternal and fetal packed cell volumes and the plasma concentrations of lactate and thyroxine remained relatively constant.

Adrenal Cortex Hormones

Plasma thyroxine concentrations in ewes and their fetuses during the last six weeks of pregnancy.

Changes in plasma thyroxine (T4) concentrations were followed in 27 fetal sheep after surgical implantation of catheters. Fourteen days were required before stable concentrations of T4 were achieved, whether surgery was performed between 90 and 96 days or 109 and 120 days gestation. Twenty-three fetuses were followed to birth, and during the last four days the T4 concentrations showed no change in 11 fetuses and a significant decrease in the other 12. Birth occurred between 142 and 157 days gestation in both groups. There was a significant rise in T4 concentration during labour in all 23 fetuses. There were large differences among the plasma T4 concentrations of individual ewes which were not related to ambient temperature.

Animals

Sparky.

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