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Biomedical subjects

J Shapiro

Publications and source records attributed to J Shapiro.

At least 271 records · Page 15Linked to original sources
PubMed1967

Induced rapid release and uptake of phosphate by microorganisms.

Cultures of bacteria and of mixed microorganisms are able to release actively a large proportion of their phosphorus to the medium in a matter of hours when kept under anoxic conditions. Only phosphorus is lost, probably as orthophosphate and apparently mostly from the acid-soluble fraction of the cells. The process, which is completely reversible upon aeration, has a change in rate (for a change of 10 degrees C) of 2 to 2.5.

Bacillus cereus↗
PubMedDate not supplied

Postanginal sepsis.

Postanginal sepsis is a septicemia resulting from an antecedent pharyngitis that causes an internal jugular vein thrombophlebitis. Because of the severity of the disease and the difficulty in its diagnosis, familiarity with all aspects of the disease is essential. We present three cases and review the literature on postanginal sepsis. The clinical course of the disease is described and its evaluation and treatment are outlined.

Adult↗
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Medicated shampoos.

Explore the source record for details and available documents.

Hair Preparations↗
PubMedDate not supplied

Thymic cyst secondary to cervical irradiation: a complication of treated laryngeal cancer.

This report demonstrates a thymic cyst arising in association with cervical irradiation for laryngeal carcinoma; a process not previously described. Thymic cysts are rare anterior mediastinal masses which have many etiologies, though an increased incidence of thymic cysts in association with Hodgkin's disease has been reported. This association was thought to be related to either mediastinal irradiation or cystic changes within a thymic focus of Hodgkin's disease. This case supports the theory that at least some thymic cysts arise secondary to irradiation.

Aged↗
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Acute renal failure in critical illness. Conventional dialysis versus acute continuous hemodiafiltration.

The dialytic therapy of choice in critically ill patients with acute renal failure (ARF) is a matter of controversy. The clinical outcome of such patients managed with either conventional dialytic therapy (CDT) or acute continuous hemodiafiltration (ACHD) was compared through retrospective review of medical records from the intensive care unit of a tertiary institution. Records from 167 critically ill patients with ARF consecutively treated in the same intensive care unit were reviewed. Eighty-four patients with ARF treated by CDT were compared to 83 treated with ACHD. The etiology of ARF and the degree of illness severity were similar in both groups (failing organs: CDT 3.9 vs. ACHD 4.1; mean APACHE II score: CDT 25.8 vs. ACHD 28.1). Overall survival was 29.8% for the CDT patients and 41% for the ACHD group (NS). In those with two to four failing organs, survival was greater in the ACHD group (53.8% vs. 31.1%; p < 0.025). This was also true for patients with an intermediate APACHE II score (24-29) who demonstrated better survival when treated by ACHD (46.4% vs. 12.5%; p < 0.025). Acute continuous hemodiafiltration was associated with better control of azotemia and hyperphosphatemia and increased nutritional intake. This retrospective study suggests that ACHD may offer clinically significant advantages over CDT, particularly in patients with an intermediate degree of critical illness severity.

Acute Kidney Injury↗
PubMedDate not supplied

Free tissue transfer in children.

We reviewed 11 cases of free tissue transfer used to salvage limbs in young patients (age range 4-16 years, mean 8.9 years). The defects were the result of acute trauma in eight cases, osteomyelitis in one, unstable scar over bony prominence in one, and correction of a previously infected talipes equinovarus repair in another patient. Donor tissues used were the latissimus dorsi muscle, scapular skin, lateral arm skin, and vascularized fibular graft. Defect sizes included 3 x 3 to 10 x 40 cm and 11 cm of humeral diaphysis. Microvascular success rate was 100%. In each case, the successful transfer provided the viable tissue required and resulted in salvage of the limb. Our results suggest that free tissue transfer is a viable solution to limb salvage in pediatric patients.

Adolescent↗
PubMedDate not supplied

Towards evidence-based use of serum tumour marker requests: an audit of use in a tertiary hospital.

BACKGROUND: Serum tumour markers (TM) are often measured in hospital patients. The reasons for their use and their benefits with regards to earlier cancer diagnosis and patient management are not known. AIMS: To identify the patterns of TM use in a tertiary hospital and to determine the usefulness and appropriateness of requests in this setting. METHODS: A cross-sectional, retrospective study of TM ordered over a 3-month period was conducted. Data were obtained from patient records. CA-125, CA 15-3, CA 19-9, carcinoembryonic antigen (CEA), and alpha-fetoprotein (AFP) were studied. Prostate specific antigen was not separately investigated. The reasons for ordering, usefulness and appropriateness of use were defined prior to analysis. RESULTS: A total of 476 TM was ordered in 373 patients. One hundred and six (22%) of all results were abnormal by laboratory criteria. AFP was the most popular test ordered. Forty-seven per cent of patients had no cancer diagnosis. Oncological units (ONC) ordered 27% of tests. The most popular reasons for TM ordering were for screening (36%) followed by diagnostic aid (19%). ONC units ordered TM mainly for monitoring disease status, as opposed to non-ONC units who ordered TM usually for diagnostic aid. TM were deemed appropriately ordered in 69% of cases. Twenty-nine per cent of TM were helpful in patient management. Only four results (<1%) aided in diagnosis. CONCLUSIONS: The reasons and appropriateness of TM use varied depending on the specialization of the requesting clinician. The current serum TM are most useful as aids in cancer patients, rather than for diagnosis (P <0.0001). Apart from AFP, these TM seem to have limited use in the general medical, non-oncological patients. Guidelines for their use in this setting are needed.

Antigens, Tumor-Associated, Carbohydrate↗
PubMedDate not supplied

Airway obstruction and sleep apnea in Hurler and Hunter syndromes.

The Hurler and Hunter syndromes are two forms of mucopolysaccharidosis. Although the diseases are rare, those afflicted commonly require otolaryngologic consultation. Upper airway obstruction is often severe, progressive, and not infrequently the suspected cause of death in these patients. Four patients with these problems are presented. In all of the children, obstructive sleep apnea was a major management problem. This and other upper airway difficulties are detailed with clinical and pathological correlates.

Airway Obstruction↗