PubMed · 8901410
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J Shapiro, S Maddin. Medicated shampoos.. https://doi.org/10.1016/0738-081x(95)00119-z
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Permethrin, a highly effective insecticide agent, has been widely used for the pest control in agriculture and the treatment of lice in human. A fast and reliable method for the determination of permethrin was highly desirable to support formulation screening and quality control. A second-derivative UV spectroscopic method was developed for the determination of permethrin in the shampoo dosage form after extraction. The second-derivative spectrum recorded between 250 and 310 nm, and a zero-crossing technique for second-derivative measurement at 279 nm was selected. It is found that the selectivity and sensitivity of the method to be in desirable range. In comparison with the direct UV method, second-derivative UV spectroscopy eliminates the interference from UV absorbing excipients. This method is also fast and economical in comparison with the more time-consuming GC method regularly used for formulation screening and quality control and can be used routinely by any laboratory possessing a spectrophotometer with a derivative accessory. The linear concentration ranges were 0.25-1.5 ppm (D2=0.00042Conc.+0.0018, r=0.9972, n=10). Between day of CV%</=2.81, within day of CV%</=3.50, and an analytical recovery close to 95-100% shows the suitability of the method for determination in quality control.
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Sensitivity of 25 strains of Pityrosporum sp. to four commercial shampoos was tested using a gel diffusion method and determination of minimum inhibitory concentrations (MICs). All the shampoos when undiluted gave inhibition zones in the gel diffusion test with 13 of the 15 strains tested. Two strains were resistant to 'Polytar'. 'Polytar' was fungistatic, 'Selsun' 'Cetavlon P.C.' and 'Genisol' were fungicidal. MIC results showed the yeast to be most sensitive to 'Cetavlon' and 'Selsun'.