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Biomedical subjects

J Shah

Publications and source records attributed to J Shah.

At least 253 records · Page 14Linked to original sources
PubMed1981

Giant ossifying fibroma of the nasal cavity with intracranial extension.

A 12-year-old white male presented with an ossifying fibroma of the maxillary sinus. The tumour recurred following incomplete excision through a maxillary approach. Computerized tomography revealed an extensive tumour involving the paranasal sinuses, which extended intracranially through the cribriform plate. The tumour was successfully excised through a combined craniofacial approach. This approach should be used whenever there is radiological involvement of the base of the skull from paranasal sinus tumours. Accurate radiological delineation of the extent of the tumour is only possible by computerized tomography in the axial and coronal planes.

Brain Neoplasms↗
PubMed1981

Edwardsiella tarda osteomyelitis in a patient with SC hemoglobinopathy.

Edwardsiella tarda is a recently identified gram-negative organism of the family Enterobacteriaceae. Reports of human infections with E tarda have been infrequent. We review 14 cases of systemic edwardsiellosis reported in the literature and report a case of E tarda osteomyelitis in a patient with sickle cell-hemoglobin C disease. In our case the remains of a snake may have been the source of the organism. Systemic edwardsiellosis is rare, and it may present as meningitis, endocarditis, bacteremia, liver abscess, or osteomyelitis. In 12 of 15 cases reported, systemic E tarda infection occurred in patients suffering from additional debilitating illnesses.

Aged↗
PubMed1980

Elective postoperative radiation therapy in stages III and IV epidermoid carcinoma of the head and neck.

One hundred five patients with advanced (American Joint Committee stages III and IV) but resectable epidermoid carcinoma of the head and neck were treated with radical surgery and elective postoperative radiation therapy. Follow-up periods range from 16 to 66 months. Nineteen patients (18 percent) have had recurrence in the head and neck area. This is better than our past experience with surgical treatment alone in advanced head and neck cancer, in which 50 to 75 percent of patients had local recurrence within the 1st 18 months. When radiation therapy was started no later than 6 weeks after surgery, only 3 of 54 patients (5.5 percent) had local recurrence, but when there was a longer delay 16 of 51 patients (31.5 percent) had recurrence. These results suggest that elective postoperative radiation therapy improves local control in patients with advanced head and neck cancer, but that it should be delivered soon after surgery for maximum effectiveness.

Carcinoma, Squamous Cell↗
PubMed1980

Craniofacial resection following chemotherapy.

A patient with intracranial extension of an ethmoidal carcinoma is reported. Since the tumor progressed in size despite conventional radiation and chemotherapy, the patient was treated with Cis-dichlorodiamine platinum). Significant regression in the intracranial component was noted, thus allowing complete excision of the tumor through a craniofacial approach. Preoperative chemotherapy with this agent may have a role in the management of patients with paranasal sinus carcinoma if intracranial extension is present.

Adenocarcinoma↗
PubMed1979

Subungual squamous cell carcinoma.

Twelve patients with subungual squamous cell carcinoma were treated at Memorial Sloan-Kettering Cancer Center during a 27-year period. To our knowledge, only 58 cases are reported in the literature. Trauma and chronic infection were predisposing factors in some of the cases, and radiation therapy was a substantive predisposing factor in our series. Disarticulation of the distal phalanx proved effective in most patients.

Adult↗
PubMed1978

Combination therapy of advanced head and neck cancer: induction of remissions with diamminedichloroplatinum (II), bleomycin and radiation therapy.

Patients with unresectable, previously untreated head and neck cancer were given cis-diamminedichloroplatinum (II) (DDP), 3 mg/kg, with mannitol diuresis (day 1), followed by a continuous infusion of bleomycin, 0.25 mg/kg/day, days 3 through 10, after an initial loading dose of 0.25 mg/kg by rapid IV injection on day 3. The DDP was repeated on day 22, following which radiotherapy was delivered using standard doses, fractionations and portals. Patients were evaluated for response on day 22 and again at the conclusion of radiotherapy. Of 21 patients evaluable at day 22, there were four CR and 11 PR (greater than 50% reduction of all measureable disease), for a major response rate of 71%. Of five MR, four showed 30-60% reduction at the primary site. Of 16 who have finished the radiation phase of treatment, there are six CR, five PR and one MR with durations four to eight months. Toxicity in 33 patients included vomiting (33), alopecia (33), WBC less than 3000 (five), platelets less than 100,000 (one), dose-limiting mucositis during bleomycin (six) and peak serum creatinine greater than 2 (five), with one fatality. The regimen thus appears promising as initial therapy for the previously untreated patient. The same chemotherapy has produced much less encouraging results in prviously treated patients.

Adult↗
PubMed1978

Stability of local rings of dimension 2.

The notion of stability of a local ring arises naturally in investigating completed moduli spaces via geometric invariant theory. A scheme corresponding to a boundary point of a moduli space of nonsingular varieties cannot have unstable singular points. This paper reports some results concerning the stability of surface singularities. If a two-dimensional Cohen-Macaulay local ring R is semistable, its multiplicity must be less than seven and either equal to or 1 less than its embedding dimension. If the multiplicity of R is equal to its embedding dimension, the singularity of R must be a simple or cyclic elliptic singularity or the nonnormal limit of such a singularity. The results for the case when the multiplicity of R is less than its embedding dimension are still incomplete; the possible singularities that may arise when the multiplicity of R is equal to 2 or 3 are described.

Journal Article↗
PubMed1977

Chemotherapy of head and neck cancer: combination treatment with cyclophosphamide, adriamycin, methotrexate, and bleomycin.

A combination of cyclophosphamide, adriamycin, methotrexate, and bleomycin (CAMB) was explored in patients with advanced, nonresectable epidermoid carcinoma from primary sites in the head and neck, recurrent or persistent after radiation or surgery. Objective regression (greater than 50%) of measurable tumor was present in 35% of the patients. The median duration of response was 2.5 months. Median survival of responders was slightly less than the nonresponders, but the difference was not significant. Drug-related morbidity was substantial; leukopenia, mucositis, and weight loss were the most frequent major side effects. Three deaths were attributable to the regimen. The results seem comparable to those one might expect from methotrexate alone.

Adult↗
PubMed1977

Comparison of intermittent catheterization and supravesical diversion in children with meningomyelocele.

A comparison in terms of renal preservation as evidenced by urography is made between children with meningomyelocele on intermittent catheterization and children who had undergone diversion. Followup in the former group is only 2 1/2 years but at this time those patients on catheterization are doing as well and probably better than children who had undergone diversion and the quality of life for them is better.

Humans↗
PubMed1977

Changes in the activities of the enzymes of hepatic ketogenesis in the rat between late fetal life and weaning.

The activities of hydroxymethylglutaryl-CoA synthase and hydroxymethylglutaryl-CoA lyase have been determined in the mitochondria and cytosol of the liver during development of the rat. Both mitochondrial enzymes exhibit similar developmental patterns with rapid rises in activity after birth, peaks of activity during early and late suckling and a trough during the mid-suckling period and a slight fall in activity (to the adult values) after weaning. Both cytosolic enzymes have low activities at all ages studied and exhibit no major developmental changes.

Aging↗