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Biomedical subjects

J Serup

Publications and source records attributed to J Serup.

At least 199 records · Page 11Linked to original sources
PubMed1979

Severe asthmatic reaction during long-term treatment with disodium cromoglycate powder inhalations.

Inhalation of inert particles may in susceptible subjects with bronchial asthma result in reflex bronchoconstriction mediated through the vagal nerves. A case of severe asthmatic reaction with bronchial spasm in a 60-year-old man with intrinsic asthma after inhalation of disodium cromoglycate powder (Lomudal) during long-term treatment is reported. The mechanism is considered to be reflexogenic. Because of the variability in individual susceptibility during long-term treatment, inhalation therapy should always be given with close attention to asthmatic exacerbations.

Asthma↗
PubMed1979

Fetal thyrotoxicosis in utero.

A case of fetal thyrotoxicosis in utero in a boy with familial predisposition to thyrotoxicosis is reported. At 26 weeks of gestation fetal hyperkinesia and fetal tachycardia developed. This was preceded by a significant pathologic increase in long-acting thyroid stimulator (LATS) in the mother. The fetal hyperkinesia and tachycardia were considered to be signs of fetal thyrotoxicosis, possibly induced by placentally transferred LATS. The fetal thyrotoxicosis responded well to propylthiouracil given to the mother. After birth the boy developed slight signs of neonatal thyrotoxicosis although his serum thyroxine values increased analogous to those of his elder sister, who had presented classical neonatal thyrotoxicosis.

Female↗
PubMed1977

The possible relation between postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis.

Hyperthyroidism is generally considered to be ameliorated during pregnancy, and there appears to be a high incidence of postpartum exacerbation. These phenomena have to our knowledge not been related to neonatal thyrotoxicosis, a transient hyperthyroidism seen only in newborns of previous or current hyperthyroid mothers. The first of two siblings of a previously thyrotoxic mother had marked symptoms of neonatal thyrotoxicosis and high levels of thyroid hormones. The mother had not received antithyroid treatment during her first pregnancy. During her next pregnancy she was treated with propylthiouracil from the second trimester. This infant had only minimal thyrotoxic signs but almost as high levels of thyroid hormones during the neonatal period as the elder. The mother had no signs of postpartum exacerbation but her thyroid hormones were significantly elevated in the postpartum period analogous to the infants. Neither the mother nor the infants presented any increase in thyroid-stimulation hormone and long-acting thyroid stimulator during the hyperthyroid periods. The possibility is discussed, that postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis may be related. They could be the result of a changed balance between a thyroid stimulator and an inhibitor after birth.

Female↗
PubMed1977

Neonatal thyrotoxicosis.

Neonatal thyrotoxicosis is a transient hyperthyroidism in infants of mothers with current or previous thyrotoxicosis. The pathogenesis have been accepted to be placental transfer of maternal thyroid stimulating immunoglobulins. Of two siblings from a previous thyrotoxic mother the first had marked symptoms of thyrotoxicosis but during the second pregnancy antithyroid treatment was given to the mother and though the child had high levels of thyroid hormones for 6 weeks it had only minimal symptoms of thyrotoxicosis.

Female↗
PubMed1977

Hyperthyroidism during pregnancy treated with propylthiouracil. The significance of maternal and foetal parameters.

Hyperthyroidism during pregnancy may be dangerous to the infant. The major risks are prematurity and neonatal thyrotoxicosis. The latter may be due to placental transfer of thyroid stimulating immunoglobulins from mother to fetus. Of two siblings of a previously thyrotoxic mother the first had marked symptoms of neonatal thyrotoxicosis after a pregnancy where no antithyroid treatment was given. The second child had only minimal thyrotoxic symptoms but almost as high levels of thyroid hormones as the first. During the second pregnancy propylthiouracil was given to the mother from 26 weeks' gestation, because of increased fetal movements and fetal tachycardia. Fetal movements and fetal heart rate were considered to be most valuable indicators of thyroid function in the fetus. Intense control is necessary from the beginning of the second trimester.

Adult↗