Biomedical subjects
Publications and source records attributed to J Seidel.
Primary amebic meningoencephalitis is a disease caused by the free-living amebae of the genera Naegleria or Acanthamoeba. The clinical course may result in death a few days after presentation or it may be insidious, with progressive neurologic deterioration and death after a chronic course. This article describes the organisms involved, the clinical course, pathology, diagnosis, and treatment of the disease.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The topohistochemistry of gamma-aminobutyric acid (GABA) was studied in the hippocampus of rats with epileptiform activity provoked by cortical implantation of cobalt-agar pellets and in control rats with implanted agar-pellets. Using the GABA specific fluorochroming procedure of Wolman (1971) a distinct decrease of GABA fluorescence was found especially in the pyramidal and granular layer, but only in the animals with a typical epileptiform activity of the EEG. The results support the hypothesis that there is a lack of GABAergic inhibition in epileptic individuals, but the anticonvulsive effect of GABA depends on structural and functional relations in the specific type of seizure.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Stimulation of the nucleus raphe dorsalis (B7) with low frequency electrical current in freely moving albino rats provoked an increase of hypersynchronous activity in the epileptogenic focus. The time course of this effect points to an action of the liberated 5-hydroxytryptamine.
After selective application of horseradish peroxidase (HRP) into the dorsal part of the lateral geniculate nucleus (LGN) of the albino rat, cells were labelled through the retrograde transport of the enzyme in the following nuclei of the brain stem: 1. Ncl. raphes linearis, 2. Nel, raphes centralis, 3. Ncl. raphes dorsalis, 4. Ncl. ventralis rostralis lemnisci lateralis, 5. Ncl. coeruleus. Using the glyoxylic acid method to demonstrate biogenic amines we could find serotonine in following areas of the brain stem: 1. region B 7 (Ncl. raphes dorsalis) positive cells; 2. region B 8 (Ncl. raphes centralis) mainly positive fibres; 3. region B 9 (dorsal of the Lemniscus medialis) a few positive cells; 4. mesencephalic reticular formation (Area cuneiformis) network-like fibre structures; 5. dorsal LGN, in the lateral part mildly fluorescing fibres, the remaining LGN showing diffuse fluorescence, 6. Substantia nigra, fluorescing cells. The monosynaptic connections between the mesencephalic raphe nuclei and the dorsal part of the LGN, demonstrated by means of the HRP-method, are characterized as being serotoninergic with the help of fluorescence histochemistry. The character of the transmitter of these connections is compared with results of biochemical and pharmacological investigations.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.