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Biomedical subjects

J Sahel

Publications and source records attributed to J Sahel.

At least 217 records · Page 12Linked to original sources
PubMed1977

A study of the variations in the response regarding duodenal ulcer when treated with placebo by different investigators.

Four series of duodenal ulcer patients presenting with pain have been treated with two types of placebos (intramuscular injections or tablets) by 4 different physicians while a fifth group of patients did not receive any treatment. Patients noted the number of days with pain since the beginning of the test by themselves. All patients treated with placebo presented with a significantly shorter duration of pain than untreated patients. There was a significant difference between the actions of the different physicians on the duration of pain. This suggests that some, until now unprecised, character(s) of the physician plays an important part in the relief of duodenal ulcer pain.

Adult↗
PubMed1977

Nonparallel secretion of enzymes in human duodenal juice and pure pancreatic juice collected by endoscopic retrograde catheterization of the papilla.

Duodenal juice was collected from 50 healthy patients in the basal state, and after intravenous injection of 1 clinical unit of secretin kg-1 + 3 Crick-Harper-Raper units of cholecystokinin-pancreozymin (CCK-PZ) kg-1. Amylase to chymotrypsin and amylase to lipase ratios were significantly decreased by stimulation. Pure pancreatic juice was collected from 7 healthy subjects by endoscopic retrograde catheterization of the papilla. Secretin (1 clinical unit kg-1 hr-1) was infused intravenously during 30 min, and a single intravenous injection of CCK-PZ (3 Crick-Harper-Raper units kg-1) was done at the 15th min of the secretin infusion. Chymotrypsinogen and lipase secretions did not parallel that of amylase during CCK-PZ stimulation. As in the first set of experiments, amylase secretion was proportionally less stimulated by CCK-PZ injection than were chymotrypsinogen and lipase secretions. However, in approximately 20% of subjects the secretion of the enzymes was parallel in both duodenal and pancreatic juice.

Ampulla of Vater↗
PubMed1976

[Pathogenesis of chronic pancreatitis (author's transl)].

The earliest change during chronic pancreatitis seems to be precipitation of proteic material consisting apparently of the normal components of pancreatic juice, as demonstrated by pathology studies. Similar changes could be induced in animal experiments. There seems to be a causal relationship between increased protein concentration in pancreatic juice and protein precipitation. The cause of the disease in most cases is alcoholism combined with a diet rich in fat and proteins, or malnutrition in infants. The mechanism of action was clarified in dogs and rats: An increase of cholinergic stimulation influencing pancreatic secretion directly seems to be involved as well as an indirect stimulation of pancreatic secretion by gastroduodenal hormones.

Alcoholism↗