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Biomedical subjects

J Ruiz

Publications and source records attributed to J Ruiz.

At least 379 records · Page 21Linked to original sources
PubMed1979

Use of the central venous pressure catheter to obtain blood cultures.

The results of aerobic and anaerobic blood cultures obtained from a peripheral venopuncture and from the central venous pressure catheter were compared in critically ill patients admitted to the ICU to determine if pain and anxiety from multiple venopunctures could be alleviated while the physician's task is facilitated. The results were identical in 93.5% of the 92 comparisons. The discrepancies were evaluated and it was concluded that the method was easy, quick, and reliable. We recommend it as a suitable alternative to venopuncture.

Bacteriological Techniques↗
PubMed1979

Effects of somatostatin on gastric mucosal histamine and serotonin content in restrained rats.

The effects of continuous intravenous perfusion of somatostatin on the incidence of ulcers and the histamine and serotonin gastric mucosal content in rats subjected to 12 h of restraint were studied. 51 sets of Sprague-Dawley male rats (102 animals) were divided at random into two groups. Those in group I were immobilized and treated with an intravenous infusion of isotonic saline solution. Animals in group II were also immobilized and given intravenous cyclic somatostatin dissolved in isotonic saline solution; the initial dose was 25 microgram and a continuous infusion of 2.5 microgram/kg/h was administered thereafter. A decrease in the ulcer index was observed in the rats perfused with somatostatin (p less than 0.01) as well as a decrease in the histamine (p less than 0.001) and serotonin (p less than 0.01) gastric mucosal contents. These effects of somatostatin on restraint-induced stress ulcer in rats are probably to be explained by microcirculatory changes in the gastric mucosa determined by the vasoactive amines (histamine and serotonin). They constitute an important factor in the pathogenesis of these lesions.

Animals↗
PubMed1979

Pharmacokinetic evaluation and mammary excretion of tamethicillin in the healthy goat.

We evaluated the pharmacokinetics and the mammary excretion of a new beta-lactam antibiotic derivative, the diethylaminoethyl ester of methicillin, commonly known as tamethicillin. Tamethicillin is a hydrolyzable weak basic ester (pro-drug) that is converted to methicillin in the body. Its pharmacokinetic profile compares favorably with that of methicillin. In this sense, tamethicillin had five times greater distribution volume than methicillin, and both its slow phase half-time (t 1/2) and elimination half-time (t 1/2 Kel) were clearly greater. In addition, our experimental studies on mammary excretion in the goat have demonstrated a better selectivity for the udder of tamethicillin as compared with methicillin. Results of 2 years of field experience show that tamethicillin can be considered a useful alternative for the treatment of mastitis in livestock, especially in mastitis due to beta-lactamase-producing Staphylococcus.

Animals↗
PubMed1978

Epinephrine-induced elevation of guanosine 3':5'-cyclic monophosphate in isolated fat cells of rat.

The effects of epinephrine (as low as 0.1 muM) on guanosine 3':5'-cyclic monophosphate (cGMP) and adenosine 3':5'-cyclic monophosphate (cAMP) in isolated fat cells were examined. Epinephrine increased both cGMP and cAMP levels, with the elevation of cAMP preceding the rise of cGMP. Maximal elevation was obtained with 1 muM epinephrine for each nucleotide. The increase in content of cGMP and cAMP due to epinephrine was completely blocked by a beta-adrenergic antagonist (5 muM propranolol). Phentolamine (10-100 muM), an alpha-adrenergic antagonist, enhanced the response to epinephrine resulting in elevation of cAMP levels, whereas a high concentration (100 muM) of phentolamine suppressed the elevation of cGMP. The ability of epinephrine to increase cGMP and cAMP levels was markedly diminished by "feedback regulator" partially purified from the incubation mixtures of isolated fat cells exposed to epinephrine [Ho, R.J. & Sutherland, E. W. (1971) J. Biol. Chem. 246, 6822-6827], whereas an increase in cGMP, but not cAMP, levels was observed in isolated fat cells incubated with "feedback regulator" alone (without epinephrine). These observations suggest the possibility that the epinephrine-induced elevation of cGMP levels in isolated fat cells might be mediated by an increase in formation of intracellular "feedback regulator" due to an elevation of cAMP by epinephrine.

Adipose Tissue↗
PubMed1975

[Completely interrupted aortic arch, ventricular septal defect and patent ductus arteriosus. A complete surgical correction in one procedure (author's transl)].

The authors present a case of completely interrupted aortic arch (Type B) associated with ventricular septal defect and patent ductus arteriosus in a child 3 years and 10 months old, who was successfully subjected to complete surgical correction in one procedure. The pre- and post-operative electrocardiographic and hemodynamic data are evaluated. The authors draw attention to the extreme rarity of surgical resolution, in one procedure, of this type of congenital heart disease.

Aorta↗
PubMedDate not supplied

[Adverse events in Intensive Medicine. Managing risk].

Health care interventions entail a risk of adverse events (AE), that may cause lesions, incapacities and even death in the patients. Given the complexity of the care of the critical patient, the Critical Care Services are a high risk setting for the appearance of AE in these patients, many of them avoidable. Several studies show the influence of organizational factors focused on the system in the reduction of care risk and on the result of the critical patients. The voluntary and anonymous registry and reporting systems make it possible to identify a significant percentage of these incidents, analyze the factors related (that contribute or limit), establish preventive strategies, permitting management of risk, and potentially reduce the appearance and consequences of avoidable AE with all this. Initiatives such as the ICU Safety Reporting System (ICUSRS), that use a web database as registry system and includes contributions from different sites, favor the safety and risk culture, essential in the improvement of health quality of critical patients.

Critical Care↗